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Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
Aggarwal G, Banerjee S, Jones SA, Benchaar Y, Bélanger J, Sévigny M, Smith DM, Niehoff ML, Pavlack M, de Vera IMS, Petkau TL, Leavitt BR, Ling K, Jafar-Nejad P, Rigo F, Morley JE, Farr SA, Dutchak PA, Sephton CF, Nguyen AD. Aggarwal G, et al. Among authors: dutchak pa. J Biol Chem. 2023 Dec;299(12):105475. doi: 10.1016/j.jbc.2023.105475. Epub 2023 Nov 18. J Biol Chem. 2023. PMID: 37981208 Free PMC article.
Metabolic Networks Influencing Skeletal Muscle Fiber Composition.
Bourdeau Julien I, Sephton CF, Dutchak PA. Bourdeau Julien I, et al. Among authors: dutchak pa. Front Cell Dev Biol. 2018 Sep 28;6:125. doi: 10.3389/fcell.2018.00125. eCollection 2018. Front Cell Dev Biol. 2018. PMID: 30324104 Free PMC article. Review.
FUS contributes to mTOR-dependent inhibition of translation.
Sévigny M, Bourdeau Julien I, Venkatasubramani JP, Hui JB, Dutchak PA, Sephton CF. Sévigny M, et al. Among authors: dutchak pa. J Biol Chem. 2020 Dec 25;295(52):18459-18473. doi: 10.1074/jbc.RA120.013801. Epub 2020 Oct 20. J Biol Chem. 2020. PMID: 33082139 Free PMC article.
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Nicolas G, Sévigny M, Lecoquierre F, Marguet F, Deschênes A, Del Pelaez MC, Feuillette S, Audebrand A, Lecourtois M, Rousseau S, Richard AC, Cassinari K, Deramecourt V, Duyckaerts C, Boland A, Deleuze JF, Meyer V, Clarimon Echavarria J, Gelpi E, Akiyama H, Hasegawa M, Kawakami I, Wong TH, Van Rooij JGJ, Van Swieten JC, Campion D, Dutchak PA, Wallon D, Lavoie-Cardinal F, Laquerrière A, Rovelet-Lecrux A, Sephton CF. Nicolas G, et al. Among authors: dutchak pa. Acta Neuropathol Commun. 2022 Feb 12;10(1):20. doi: 10.1186/s40478-022-01314-x. Acta Neuropathol Commun. 2022. PMID: 35151370 Free PMC article.
12 results