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1993 1
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287 results

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Page 1
PNPO-Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/beta-Catenin Pathway.
Deng Z, Sun S, Zhou N, Peng Y, Cheng L, Yu X, Yuan Y, Guo M, Xu M, Cheng Y, Zhou F, Li N, Yang Y, Gu C. Deng Z, et al. Adv Sci (Weinh). 2025 Feb;12(5):e2407681. doi: 10.1002/advs.202407681. Epub 2024 Dec 10. Adv Sci (Weinh). 2025. PMID: 39656865 Free PMC article.
Mechanistically, PNPO oxidizes disheveled 3(M282) (DVL3), leading to abnormal activation of the Wnt/beta-catenin pathway. Based on the critical sites of PNPO(R95/K117), Eltrombopag is identified as a potential therapeutic candidate for MM. ...Eltrombopag inhibited the grow …
Mechanistically, PNPO oxidizes disheveled 3(M282) (DVL3), leading to abnormal activation of the Wnt/beta-catenin pathway. Based on th …
Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway.
Tan W, Chen N, Qiu Y, Feng X, Li S, Zhang Y, Li H, Gao J, Zhao D. Tan W, et al. Autoimmunity. 2022 Aug;55(5):285-293. doi: 10.1080/08916934.2022.2067984. Epub 2022 May 2. Autoimmunity. 2022. PMID: 35499309 Free article.
OBJECTIVE: This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. METHODS: The expression pattern of Dvl3 was examined by IHC, WB, and qPCR. ...The augment of TNF-alpha, IL-1beta, IL-17, and IL-21 was observed in ex …
OBJECTIVE: This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. METHODS: The exp …
WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
Zhao H, Wu G, Luo Y, Xie Y, Han Y, Zhang D, Han Q, Zhao X, Qin Y, Li Q, Wang E. Zhao H, et al. Cell Signal. 2024 Oct;122:111330. doi: 10.1016/j.cellsig.2024.111330. Epub 2024 Jul 31. Cell Signal. 2024. PMID: 39094673 Free article.
Interactions were identified among WNT5B, frizzled3 (FZD3), and disheveled3 (DVL3) in NSCLC cells, leading to the activation of WNT-PCP signaling. The FZD3 receptor initiates DVL3 recruitment to the membrane for phosphorylation in a WNT5B ligand-dependent manner and …
Interactions were identified among WNT5B, frizzled3 (FZD3), and disheveled3 (DVL3) in NSCLC cells, leading to the activation of WNT-P …
DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.
Pruller J, Figeac N, Zammit PS. Pruller J, et al. Sci Rep. 2022 May 19;12(1):8388. doi: 10.1038/s41598-022-10536-x. Sci Rep. 2022. PMID: 35589804 Free PMC article.
DVL1 and DVL3 also contribute to regulation of proliferation in rhabdomyosarcoma. DVL1 or DVL3 must be present in the nucleus to regulate proliferation, but they operate through different protein domains: DVL3 requires the DIX and PDZ domains, while DVL1 does …
DVL1 and DVL3 also contribute to regulation of proliferation in rhabdomyosarcoma. DVL1 or DVL3 must be present in the nucleus …
Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway.
Zhang Y, Lin N, Liu X, Yao T. Zhang Y, et al. Arch Esp Urol. 2024 Mar;77(2):193-201. doi: 10.56434/j.arch.esp.urol.20247702.25. Arch Esp Urol. 2024. PMID: 38583012 Free article.

LPS stimulation increased (p < 0.01) the expression of DVL3 in PC3 cells. DVL3 regulated tumor cell proliferation and migration by mediating the increase (p < 0.01) in TLR4 expression. Knockout of TLR4 validated that TLR4 played a crucial role in LPS-induced

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LPS stimulation increased (p < 0.01) the expression of DVL3 in PC3 cells. DVL3 regulated tumor cell proliferation and migra

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Polymorphism and expression of the Dvl3 gene in the etiology of depressive disorder.
Zajączkowska M, Talarowska M, Szemraj J, Gałecki P. Zajączkowska M, et al. Psychiatr Pol. 2020 Jun 30;54(3):509-523. doi: 10.12740/PP/103853. Epub 2020 Jun 30. Psychiatr Pol. 2020. PMID: 33038884 Free article. English, Polish.
OBJECTIVES: The aim of this study was to investigate the role of the Dvl3 gene in the etiology of depression by comparison of Dvl3 mRNA expression, Dvl3 protein levels and polymorphism at locus rs1969253 located in the intron of the Dvl3 gene in patien …
OBJECTIVES: The aim of this study was to investigate the role of the Dvl3 gene in the etiology of depression by comparison of Dvl3 …
Silencing DVL3 defeats MTX resistance and attenuates stemness via Notch Signaling Pathway in colorectal cancer.
Zhao Q, Zhuang K, Han K, Tang H, Wang Y, Si W, Yang Z. Zhao Q, et al. Pathol Res Pract. 2020 Aug;216(8):152964. doi: 10.1016/j.prp.2020.152964. Epub 2020 Apr 25. Pathol Res Pract. 2020. PMID: 32414668
However, the underlying biological function of DVL3 still remains unclear. In this study, we proposed DVL3 was simultaneously involved in Methotrexate (MTX) resistance and Colorectal cancer (CRC) stemness by bioinformatic analysis. ...Accordingly, our data suggest t …
However, the underlying biological function of DVL3 still remains unclear. In this study, we proposed DVL3 was simultaneously …
Circ_0101802 Facilitates Colorectal Cancer Progression Depending on the Regulation of miR-665/DVL3 Signaling.
Li J, Liu X, Dong S, Liao H, Huang W, Yuan X. Li J, et al. Biochem Genet. 2022 Dec;60(6):2250-2267. doi: 10.1007/s10528-022-10207-6. Epub 2022 Mar 21. Biochem Genet. 2022. PMID: 35314912
Finally, xenograft tumor model was established to confirm the role of circ_0101802/miR-665/DVL3 axis in tumor growth in vivo. The expression of DVL3 and circ_0101802 was elevated in CRC tissues and cell lines, and high levels of DVL3 and circ_0101802 were clo …
Finally, xenograft tumor model was established to confirm the role of circ_0101802/miR-665/DVL3 axis in tumor growth in vivo. The exp …
Role and mechanism of Dvl3 in the esophageal squamous cell carcinoma.
Chen XQ, Jiang J, Wang XT, Zhang CL, Ji AY, Chen XJ. Chen XQ, et al. Eur Rev Med Pharmacol Sci. 2018 Nov;22(22):7716-7725. doi: 10.26355/eurrev_201811_16393. Eur Rev Med Pharmacol Sci. 2018. PMID: 30536315 Free article.
RESULTS: Dvl3 promoted the proliferation of esophageal squamous cell carcinoma cells and cell migration of cells expressing Dvl3 siRNA was significantly lower than that of the non-transfected cells. Flow cytometry showed that silencing Dvl3 promoted apoptosis …
RESULTS: Dvl3 promoted the proliferation of esophageal squamous cell carcinoma cells and cell migration of cells expressing Dvl3 …
The Gender-Specific Interaction of DVL3 and GSK3beta Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
Ke S, Li J, Zhao L, Yang J, Zhao X, Zhang W, Qiu X, Yang X, Zhou J, Tong Y, Zhu X, Liu X, Yang Y, Qiao Z, Bu T. Ke S, et al. Oxid Med Cell Longev. 2022 Jan 28;2022:2633127. doi: 10.1155/2022/2633127. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35126809 Free PMC article.

The genotype and haplotype frequencies of DVL3/GSK3beta polymorphisms were significantly different between patients and controls for DVL3 rs1709642 (P < 0.01) and GSK3beta rs334558, rs6438552, and rs2199503 (P < 0.01). ...This study reveals the interaction bet

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The genotype and haplotype frequencies of DVL3/GSK3beta polymorphisms were significantly different between patients and controls for …
287 results