Streptozotocin as a tool for induction of rat models of diabetes: a practical guide.
Ghasemi A, Jeddi S.
Ghasemi A, et al.
EXCLI J. 2023 Feb 21;22:274-294. doi: 10.17179/excli2022-5720. eCollection 2023.
EXCLI J. 2023.
PMID: 36998708
Free PMC article.
Review.
Wistar and Sprague-Dawley rats, the most commonly-used rat strains, are sensitive to STZ, but some strains (e.g., Wistar-Kyoto rats) are less sensitive. STZ is mostly injected intravenously or intraperitoneally, but its intravenous injection produces more stable hyperglyce …
Wistar and Sprague-Dawley rats, the most commonly-used rat strains, are sensitive to STZ, but some strains (e.g., Wistar-Kyoto rats) …