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Page 1
Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the Epidemiology of Musculoskeletal Conditions and Aging.
Ladang A, Beaudart C, Reginster JY, Al-Daghri N, Bruyère O, Burlet N, Cesari M, Cherubini A, da Silva MC, Cooper C, Cruz-Jentoft AJ, Landi F, Laslop A, Maggi S, Mobasheri A, Ormarsdottir S, Radermecker R, Visser M, Yerro MCP, Rizzoli R, Cavalier E. Ladang A, et al. Calcif Tissue Int. 2023 Feb;112(2):197-217. doi: 10.1007/s00223-022-01054-z. Epub 2023 Jan 12. Calcif Tissue Int. 2023. PMID: 36633611 Free PMC article. Review.
For series 1, the group agreed on 4 biochemical markers that should be assessed in Phase II or Phase III trials (i.e., Myostatin-Follistatin, Brain Derived Neurotrophic Factor, N-terminal Type III Procollagen and Serum Creatinine to Serum Cystatin C Ratio - or the Sarcopen …
For series 1, the group agreed on 4 biochemical markers that should be assessed in Phase II or Phase III trials (i.e., Myostatin-Foll …
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.
Shay JW, Homma N, Zhou R, Naseer MI, Chaudhary AG, Al-Qahtani M, Hirokawa N, Goudarzi M, Fornace AJ Jr, Baeesa S, Hussain D, Bangash M, Alghamdi F, Schulten HJ, Carracedo A, Khan I, Qashqari H, Madkhali N, Saka M, Saini KS, Jamal A, Al-Maghrabi J, Abuzenadah A, Chaudhary A, Al Qahtani M, Damanhouri G, Alkhatabi H, Goodeve A, Crookes L, Niksic N, Beauchamp N, Abuzenadah AM, Vaught J, Budowle B, Assidi M, Buhmeida A, Al-Maghrabi J, Buhmeida A, Assidi M, Merdad L, Kumar S, Miura S, Gomez K, Carracedo A, Rasool M, Rebai A, Karim S, Eldin HFN, Abusamra H, Alhathli EM, Salem N, Al-Qahtani MH, Kumar S, Faheem H, Agarwa A, Nieschlag E, Wistuba J, Damm OS, Beg MA, Abdel-Meguid TA, Mosli HA, Bajouh OS, Abuzenadah AM, Al-Qahtani MH, Coskun S, Abu-Elmagd M, Buhmeida A, Dallol A, Al-Maghrabi J, Hakamy S, Al-Qahtani W, Al-Harbi A, Hussain S, Assidi M, Al-Qahtani M, Abuzenadah A, Ozkosem B, DuBois R, Messaoudi SS, Dandana MT, Mahjoub T, Almawi WY, Abdalla S, Al-Aama MN, Elzawahry A, Takahashi T, Mimaki S, Furukawa E, Nakatsuka R, Kurosaka I, Nishigaki T, Nakamura H, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M, Mehmood S, Ashraf NM, Asif A, Bilal M, Mehmood MS, Hussain … See abstract for full author list ➔ Shay JW, et al. BMC Genomics. 2016 Jul 20;17 Suppl 6(Suppl 6):487. doi: 10.1186/s12864-016-2858-0. BMC Genomics. 2016. PMID: 27454254 Free PMC article.
Philip McCoy P30 Development of real time PCR diagnostic protocol specific for the Saudi Arabian H1N1 viral strains Adel E El-Tarras, Nabil S Awad, Abdulla A Alharthi, Mohamed M M Ibrahim P31 Identification of novel genetic variations affecting Osteoarthritis patients Hane …
Philip McCoy P30 Development of real time PCR diagnostic protocol specific for the Saudi Arabian H1N1 viral strains Adel E El-Tarras, …
Additive manufacturing of bioactive glass biomaterials.
Simorgh S, Alasvand N, Khodadadi M, Ghobadi F, Malekzadeh Kebria M, Brouki Milan P, Kargozar S, Baino F, Mobasheri A, Mozafari M. Simorgh S, et al. Methods. 2022 Dec;208:75-91. doi: 10.1016/j.ymeth.2022.10.010. Epub 2022 Nov 2. Methods. 2022. PMID: 36334889 Free article. Review.
Up to now, several organic and inorganic materials were used as raw materials for 3D printing; bioactive glasses (BGs) are among the most hopeful substances regarding their excellent properties (e.g., bioactivity and biocompatibility). In addition, the reported studies hav …
Up to now, several organic and inorganic materials were used as raw materials for 3D printing; bioactive glasses (BGs) are among the most ho …
Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics.
Karsdal M, Cox TR, Parker AL, Willumsen N, Sand JMB, Jenkins G, Hansen HH, Oldenburger A, Geillinger-Kaestle KE, Larsen AT, Black D, Genovese F, Eckersley A, Heinz A, Nyström A, Holm Nielsen S, Bennink L, Johannsson L, Bay-Jensen AC, Orange DE, Friedman S, Røpke M, Fiore V, Schuppan D, Rieder F, Simona B, Borthwick L, Skarsfeldt M, Wennbo H, Thakker P, Stoffel R, Clarke GW, Kalluri R, Ruane D, Zannad F, Mortensen JH, Sinkeviciute D, Sundberg F, Coseno M, Thudium C, Croft AP, Khanna D, Cooreman M, Broermann A, Leeming DJ, Mobasheri A, Ricard-Blum S. Karsdal M, et al. J Clin Med. 2025 Mar 10;14(6):1856. doi: 10.3390/jcm14061856. J Clin Med. 2025. PMID: 40142664 Free PMC article. Review.
LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Elayyan J, Lee EJ, Gabay O, Smith CA, Qiq O, Reich E, Mobasheri A, Henrotin Y, Kimber SJ, Dvir-Ginzberg M. Elayyan J, et al. FASEB J. 2017 Jul;31(7):3116-3125. doi: 10.1096/fj.201601253R. Epub 2017 Apr 7. FASEB J. 2017. PMID: 28389425 Free article.
Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, through repression of the transcription factor LEF1, a known modulator of MMP13 gene expression.-Elayyan, J., Lee, E.-J., Gabay, O., …
Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, …
Novel approaches to the stratified management of knee osteoarthritis.
Fuggle NR, Chapurlat R, Laslop A, Al-Daghri N, Alokail M, Thiyagarajan JA, Balkowiec-Iskra E, Berenbaum F, Bemden AB, Borg JJ, Bruyère O, Burlet N, Cavalier E, Rosa MM, Conaghan PG, Cooper C, Dennison EM, Englund M, Im GI, Haugen IK, Hiligsmann M, Kurth A, Lane N, Lories R, Marlovits S, Matijevic R, Mobasheri A, Ormarsdóttir S, Yerro MCP, Radermecker RP, Rannou F, Sepodes B, Silverman S, Torre C, Veronese N, Rizzoli R, Reginster JY, Harvey NC. Fuggle NR, et al. Nat Rev Rheumatol. 2025 Nov;21(11):684-695. doi: 10.1038/s41584-025-01305-x. Epub 2025 Oct 3. Nat Rev Rheumatol. 2025. PMID: 41044417 Review.
Osteoarthritis year 2012 in review: biomarkers.
Mobasheri A. Mobasheri A. Osteoarthritis Cartilage. 2012 Dec;20(12):1451-64. doi: 10.1016/j.joca.2012.07.009. Epub 2012 Jul 25. Osteoarthritis Cartilage. 2012. PMID: 22842200 Free article. Review.
Combining biochemical markers with tissue and cell imaging techniques and bioinformatics (i.e., machine learning, clustering, data visualization) may facilitate the development of biomarker combinations enabling earlier detection of OA....
Combining biochemical markers with tissue and cell imaging techniques and bioinformatics (i.e., machine learning, clustering, data vi …
Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression.
Zhu L, Diao X, Yuan C, Lau CML, Wang J, Wu W, Mobasheri A, Houard X, Wen C, Cai Z. Zhu L, et al. Theranostics. 2025 Aug 30;15(18):9729-9741. doi: 10.7150/thno.117788. eCollection 2025. Theranostics. 2025. PMID: 41041046 Free PMC article.
Results: Clustering 3534 proteins and 79 energy metabolites from spatial proteomic and metabolomic image datasets reveals four distinct functional stages of OA synovitis, i.e., quiescent, microvasculopathic, pre-fibrotic, and post-fibrotic stages, which enables constructio …
Results: Clustering 3534 proteins and 79 energy metabolites from spatial proteomic and metabolomic image datasets reveals four distinct func …
Recommendations for robust and reproducible preclinical research in personalised medicine.
Fosse V, Oldoni E, Bietrix F, Budillon A, Daskalopoulos EP, Fratelli M, Gerlach B, Groenen PMA, Hölter SM, Menon JML, Mobasheri A, Osborne N, Ritskes-Hoitinga M, Ryll B, Schmitt E, Ussi A, Andreu AL, McCormack E; PERMIT group. Fosse V, et al. BMC Med. 2023 Jan 8;21(1):14. doi: 10.1186/s12916-022-02719-0. BMC Med. 2023. PMID: 36617553 Free PMC article. Review.
The crossroads between cancer stem cells and aging.
Santos Franco S, Raveh-Amit H, Kobolák J, Alqahtani MH, Mobasheri A, Dinnyes A. Santos Franco S, et al. BMC Cancer. 2015;15 Suppl 1(Suppl 1):S1. doi: 10.1186/1471-2407-15-S1-S1. Epub 2015 Jan 15. BMC Cancer. 2015. PMID: 25708542 Free PMC article. Review.
Although research in the field is progressing extremely fast, proof of concept for the CSC hypothesis is still lacking and key questions remain unanswered, e.g. the cell of origin for these cells. Nevertheless, it is undisputed that neoplastic transformation is associated …
Although research in the field is progressing extremely fast, proof of concept for the CSC hypothesis is still lacking and key questions rem …
52 results