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Genome editing in K562 cells suggests a functional role for the XmnI Gg polymorphism: a widely used genetic marker in β-thalassemia and sickle cell disease patients.
Ahmadifard A, Maroofi N, Maleki Tehrani M, Dabestani T, Sadat Mousavi Maleki M, Bayrami S, Banan M. Ahmadifard A, et al. Cell Mol Biol (Noisy-le-grand). 2024 Jul 28;70(7):230-236. doi: 10.14715/cmb/2024.70.7.33. Cell Mol Biol (Noisy-le-grand). 2024. PMID: 39097869
To gain insight, green fluorescence protein (GFP) cassettes harboring the XmnI C or T alleles in their left homology arms (i.e. Gg promoters) were knocked into the Gg gene(s) of K562 cells via CRISPR/Cas9. Subsequently, the GFP fluorescence levels were compared in the ensu …
To gain insight, green fluorescence protein (GFP) cassettes harboring the XmnI C or T alleles in their left homology arms (i.e. Gg pr …
Support for "Disease-Only" Genotypes and Excess of Homozygosity at the CYTH4 Primate-Specific GTTT-Repeat in Schizophrenia.
Khademi E, Alehabib E, Shandiz EE, Ahmadifard A, Andarva M, Jamshidi J, Rahimi-Aliabadi S, Pouriran R, Nejad FR, Mansoori N, Shahmohammadibeni N, Taghavi S, Shokraeian P, Akhavan-Niaki H, Paisán-Ruiz C, Darvish H, Ohadi M. Khademi E, et al. Genet Test Mol Biomarkers. 2017 Aug;21(8):485-490. doi: 10.1089/gtmb.2016.0422. Epub 2017 Jul 19. Genet Test Mol Biomarkers. 2017. PMID: 28723299
These STRs may regulate genes that participate in characteristics that are associated with the divergence of primates from sibling orders (e.g., brain higher order functions). The CYTH4 gene contains the longest tetranucleotide STR in its core promoter, at 7-repeats, and l …
These STRs may regulate genes that participate in characteristics that are associated with the divergence of primates from sibling orders ( …