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Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.
Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. Stobdan T, et al. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10425-30. doi: 10.1073/pnas.1507486112. Epub 2015 Aug 3. Proc Natl Acad Sci U S A. 2015. PMID: 26240367 Free PMC article.
To test whether EDNRB plays a critical role in hypoxia tolerance and adaptation, we generated EdnrB knockout mice and found that when EdnrB (-/+) heterozygote mice are treated with lower levels of oxygen (O2), they tolerate various levels of hypoxia (even extreme hypoxia, e
To test whether EDNRB plays a critical role in hypoxia tolerance and adaptation, we generated EdnrB knockout mice and found that when EdnrB …
A total synthesis of estrone based on a novel cascade of radical cyclizations.
Pattenden G, Gonzalez MA, McCulloch S, Walter A, Woodhead SJ. Pattenden G, et al. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12024-9. doi: 10.1073/pnas.0401925101. Epub 2004 Aug 10. Proc Natl Acad Sci U S A. 2004. PMID: 15304654 Free PMC article.
A number of alternative substituted iodopolyenynones and iodovinylcyclopropanes, i.e., 8a, 8b, 33, 49a, and 49b, underwent similar radical-mediated cascade cyclizations leading to other estranes, i.e., 21a, 21b, 35, and 50, and, in one case, to the 6,6,5,6-tetracycl …
A number of alternative substituted iodopolyenynones and iodovinylcyclopropanes, i.e., 8a, 8b, 33, 49a, and 49b, underwent similar ra …
Functional role for vasoactive intestinal polypeptide in the caudate nucleus: a 2-deoxy[14C]glucose investigation.
McCulloch J, Kelly PA, Uddman R, Edvinsson L. McCulloch J, et al. Proc Natl Acad Sci U S A. 1983 Mar;80(5):1472-6. doi: 10.1073/pnas.80.5.1472. Proc Natl Acad Sci U S A. 1983. PMID: 6572400 Free PMC article.
Significantly increased glucose utilization after intrastriatal injection of vasoactive intestinal polypeptide was observed in a number of regions (e.g., substantia nigra pars compacta, entopeduncular nucleus, lateral habenular nucleus, entorhinal, pyriform cortices, and a …
Significantly increased glucose utilization after intrastriatal injection of vasoactive intestinal polypeptide was observed in a number of r …