Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS.
Bonthron C, Burley S, Broadhead MJ, Metodieva V, Grant SGN, Chandran S, Miles GB.
Bonthron C, et al.
PLoS One. 2024 Aug 1;19(8):e0306423. doi: 10.1371/journal.pone.0306423. eCollection 2024.
PLoS One. 2024.
PMID: 39088455
Free PMC article.
Changes in the relative amount of excitatory to inhibitory inputs onto a neuron (E:I synaptic ratio), possibly through a developmental shift in synapse formation in favour of excitatory transmission, could underlie pathological hyperexcitability. ...Further to this, analys …
Changes in the relative amount of excitatory to inhibitory inputs onto a neuron (E:I synaptic ratio), possibly through a developmenta …