Imaging Proinflammatory Microglia in Parkinson Disease Using [11C]SMW139 PET: A Multicenter Study.
Rikken RM, van de Giessen E, Brumberg J, Aarnio R, Joling M, Forsberg Morén A, Kerstens V, Moein MM, Nag S, Halldin C, Fazio P, Roos DS, Berendse HW, Kassiou M, Wahlroos S, Haaparanta-Solin M, Oikonen V, Schuit RC, Boellaard R, Windhorst AD, Jacobs AH, Lammertsma AA, Rinne JO, Varrone A, Golla SSV.
Rikken RM, et al.
J Nucl Med. 2025 Oct 1;66(10):1646-1651. doi: 10.2967/jnumed.125.269671.
J Nucl Med. 2025.
PMID: 40774697
A 2-tissue compartment model with dual-input curves (both unchanged radiopharmaceutical [i.e., parent] and radiometabolites) was used to quantify [(11)C]SMW139. The distribution volume of the parent (V (Tp)) was considered the main parameter of interest. ...
A 2-tissue compartment model with dual-input curves (both unchanged radiopharmaceutical [i.e., parent] and radiometabolites) was used …