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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 3
1996 5
1997 5
1998 8
1999 4
2000 5
2001 10
2002 4
2003 7
2004 5
2005 7
2006 11
2007 6
2008 2
2009 3
2010 5
2011 3
2012 4
2013 1
2014 1
2015 1
2016 1
2018 2
2019 3
2020 1
2021 0
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100 results
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Page 1
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Scheuner D, et al. Among authors: eckman c. Nat Med. 1996 Aug;2(8):864-70. doi: 10.1038/nm0896-864. Nat Med. 1996. PMID: 8705854
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Farris W, et al. Among authors: eckman cb. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4162-7. doi: 10.1073/pnas.0230450100. Epub 2003 Mar 12. Proc Natl Acad Sci U S A. 2003. PMID: 12634421 Free PMC article.
An update on the amyloid hypothesis.
Eckman CB, Eckman EA. Eckman CB, et al. Neurol Clin. 2007 Aug;25(3):669-82, vi. doi: 10.1016/j.ncl.2007.03.007. Neurol Clin. 2007. PMID: 17659184 Free PMC article. Review.
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