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82 results

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The EDC4-XRN1 interaction controls P-body dynamics to link mRNA decapping with decay.
Brothers WR, Ali F, Kajjo S, Fabian MR. Brothers WR, et al. EMBO J. 2023 Nov 2;42(21):e113933. doi: 10.15252/embj.2023113933. Epub 2023 Aug 25. EMBO J. 2023. PMID: 37621215 Free PMC article.
Here, we show that disrupting the EDC4-XRN1 interaction or altering their stoichiometry inhibits mRNA decapping, with microRNA-targeted mRNAs being stabilized in a translationally repressed state. ...Taken together, these data demonstrate that the interaction between XRN1 …
Here, we show that disrupting the EDC4-XRN1 interaction or altering their stoichiometry inhibits mRNA decapping, with microRNA-target …
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR, Carr SA, Lindquist S, De Jager PL, Bartel DP, Myers CL, Greenamyre JT, Feany MB, Sunyaev SR, Chung CY, Khurana V. Hallacli E, et al. Cell. 2022 Jun 9;185(12):2035-2056.e33. doi: 10.1016/j.cell.2022.05.008. Cell. 2022. PMID: 35688132 Free PMC article.
The N terminus of alphaS, but not other synucleins, dictates mutually exclusive binding either to cellular membranes or to P-bodies in the cytosol. alphaS associates with multiple decapping proteins in close proximity on the Edc4 scaffold. As alphaS pathologically accumula …
The N terminus of alphaS, but not other synucleins, dictates mutually exclusive binding either to cellular membranes or to P-bodies in the c …
EDC4 C-terminal domain scaffolds P-body assembly and links P-body dynamics to p53-mediated tumor suppression.
Cheng YH, Chen TW, Chiang WC, Kuo JC, Ho YS, Noble M, Chang CT. Cheng YH, et al. RNA. 2025 Jul 16;31(8):1176-1194. doi: 10.1261/rna.080561.125. RNA. 2025. PMID: 40360209
Here, we identify the C-terminal domain of EDC4 as the minimal region required for P-body formation, with residues 1266-1401 driving phase separation and EDC4 condensation. ...Our results revealed that the NBDY 22-41 peptide directly binds the EDC4 C-terminal …
Here, we identify the C-terminal domain of EDC4 as the minimal region required for P-body formation, with residues 1266-1401 driving …
EDC4 enhances multi-drug chemosensitivity in pancreatic cancer via GR50-based profiling.
Qin C, Li T, Zhao B, Li Z, Zhao Y, Zhang X, Xie Y, Yan Y, Han J, Shao Q, Lin C, Wang W. Qin C, et al. Cancer Cell Int. 2025 Oct 10;25(1):347. doi: 10.1186/s12935-025-04000-9. Cancer Cell Int. 2025. PMID: 41073999 Free PMC article.
EDC4 was selected for further analysis due to its highest correlation coefficient in the multivariate Cox regression model. ...MATN3 and SGCE were identified as downstream targets of EDC4. Immunohistochemistry of tissue microarrays confirmed that low EDC4 lev …
EDC4 was selected for further analysis due to its highest correlation coefficient in the multivariate Cox regression model. ...MATN3 …
P-bodies directly regulate MARF1-mediated mRNA decay in human cells.
Brothers WR, Fakim H, Kajjo S, Fabian MR. Brothers WR, et al. Nucleic Acids Res. 2022 Jul 22;50(13):7623-7636. doi: 10.1093/nar/gkac557. Nucleic Acids Res. 2022. PMID: 35801873 Free PMC article.
How EDC4 interacts with MARF1 and how it represses MARF1 activity is unclear. In this study, we show that human MARF1 and XRN1 interact with EDC4 using analogous conserved short linear motifs in a mutually exclusive manner. While the EDC4-MARF1 interaction is …
How EDC4 interacts with MARF1 and how it represses MARF1 activity is unclear. In this study, we show that human MARF1 and XRN1 intera …
The molecular axis hnRNPU/circKCNK2/EDC4/IL-11 aggravates osteolytic bone metastasis of RCC.
Wang Y, Zhao D, Lu J, Hou N, Wu Q, Zhou S, Xu J, Xue W, Cui W, Zheng J, Wang F, Zhai W. Wang Y, et al. Oncogene. 2025 Sep;44(36):3310-3332. doi: 10.1038/s41388-025-03476-z. Epub 2025 Jul 11. Oncogene. 2025. PMID: 40640337 Free PMC article.
At the molecular level, circKCNK2 is competitively bound to EDC4 (a scaffold protein of P-bodies). The interaction between circKCNK2 and EDC4alpha-helical disrupted the combination of DCP1 and DCP2, which weakened the function of P-bodies and resulted in an increased level …
At the molecular level, circKCNK2 is competitively bound to EDC4 (a scaffold protein of P-bodies). The interaction between circKCNK2 …
Assembly and regulation of the mammalian mRNA processing body.
Bloch DB, Sinow CO, Sauer AJ, Corman BHP. Bloch DB, et al. PLoS One. 2023 Mar 6;18(3):e0282496. doi: 10.1371/journal.pone.0282496. eCollection 2023. PLoS One. 2023. PMID: 36877681 Free PMC article.
LSm14a, PATL1, XRN1, and NBDY were found to interact with the N-terminal, WD40-domain-containing portion of EDC4. The N-terminus of full-length PATL1 was required to mediate the interaction between EDC4 and DDX6. ...Despite the absence of endogenous P-bodies, this p …
LSm14a, PATL1, XRN1, and NBDY were found to interact with the N-terminal, WD40-domain-containing portion of EDC4. The N-terminus of f …
Dynamic "Cap"-abilities of P-bodies and the XRN1-EDC4 axis.
Malsick LE, Wilusz J. Malsick LE, et al. EMBO J. 2023 Nov 2;42(21):e115310. doi: 10.15252/embj.2023115310. Epub 2023 Sep 26. EMBO J. 2023. PMID: 37750488 Free PMC article.
In this issue, Brothers et al reveal the importance of balanced communication between the Xrn1 exonuclease and the EDC4 decapping factor to coordinate P-body dynamics and maintain cellular fitness....
In this issue, Brothers et al reveal the importance of balanced communication between the Xrn1 exonuclease and the EDC4 decapping fac …
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
Hernández G, Ramírez MJ, Minguillón J, Quiles P, Ruiz de Garibay G, Aza-Carmona M, Bogliolo M, Pujol R, Prados-Carvajal R, Fernández J, García N, López A, Gutiérrez-Enríquez S, Diez O, Benítez J, Salinas M, Teulé A, Brunet J, Radice P, Peterlongo P, Schindler D, Huertas P, Puente XS, Lázaro C, Pujana MÀ, Surrallés J. Hernández G, et al. Nat Commun. 2018 Mar 6;9(1):967. doi: 10.1038/s41467-018-03433-3. Nat Commun. 2018. PMID: 29511213 Free PMC article.
EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. EDC4 deficiency leads to genome instability and hypersensitivity to DNA interstrand cross-linking drugs and PARP inhibitors. ...
EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. EDC4 deficiency leads …
EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.
Gudkova D, Panasyuk G, Nemazanyy I, Zhyvoloup A, Monteil P, Filonenko V, Gout I. Gudkova D, et al. FEBS Lett. 2012 Oct 19;586(20):3590-5. doi: 10.1016/j.febslet.2012.08.033. Epub 2012 Sep 13. FEBS Lett. 2012. PMID: 22982864 Free article.
Here we describe that CoAsy forms a complex with enhancer of mRNA-decapping protein 4 (EDC4), a central scaffold component of processing bodies. CoAsy/EDC4 complex formation is regulated by growth factors and is affected by cellular stresses. EDC4 strongly in …
Here we describe that CoAsy forms a complex with enhancer of mRNA-decapping protein 4 (EDC4), a central scaffold component of process …
82 results