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Page 1
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Tamayo NA, Bourbeau MP, Allen JR, Ashton KS, Chen JJ, Kaller MR, Nguyen TT, Nishimura N, Pettus LH, Walton M, Belmontes B, Moriguchi J, Chen K, McCarter JD, Hanestad K, Chung G, Ninniri MSS, Sun J, Poppe L, Spahr C, Hui J, Jia L, Wu T, Dahal UP, Edson KZ, Payton M. Tamayo NA, et al. Among authors: edson kz. J Med Chem. 2022 Mar 24;65(6):4972-4990. doi: 10.1021/acs.jmedchem.1c02030. Epub 2022 Mar 14. J Med Chem. 2022. PMID: 35286090
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Payton M, Belmontes B, Hanestad K, Moriguchi J, Chen K, McCarter JD, Chung G, Ninniri MS, Sun J, Manoukian R, Chambers S, Ho SM, Kurzeja RJM, Edson KZ, Dahal UP, Wu T, Wannberg S, Beltran PJ, Canon J, Boghossian AS, Rees MG, Ronan MM, Roth JA, Minocherhomji S, Bourbeau MP, Allen JR, Coxon A, Tamayo NA, Hughes PE. Payton M, et al. Among authors: edson kz. Nat Cancer. 2024 Jan;5(1):66-84. doi: 10.1038/s43018-023-00699-5. Epub 2023 Dec 27. Nat Cancer. 2024. PMID: 38151625 Free PMC article.
Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer.
Johnson AL, Edson KZ, Totah RA, Rettie AE. Johnson AL, et al. Among authors: edson kz. Adv Pharmacol. 2015;74:223-62. doi: 10.1016/bs.apha.2015.05.002. Epub 2015 Jun 27. Adv Pharmacol. 2015. PMID: 26233909 Free PMC article. Review.
Arshad MN, Edson KZ, Mough ST, Holman KT. Arshad MN, et al. Among authors: edson kz. Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 13;66(Pt 4):o834. doi: 10.1107/S160053681000718X. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21580661 Free PMC article.
Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies.
Roellecke K, Virts EL, Einholz R, Edson KZ, Altvater B, Rossig C, von Laer D, Scheckenbach K, Wagenmann M, Reinhardt D, Kramm CM, Rettie AE, Wiek C, Hanenberg H. Roellecke K, et al. Among authors: edson kz. Gene Ther. 2016 Jul;23(7):615-26. doi: 10.1038/gt.2016.38. Epub 2016 May 19. Gene Ther. 2016. PMID: 27092941
Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide).
Subramanian R, Zhu X, Kerr SJ, Esmay JD, Louie SW, Edson KZ, Walter S, Fitzsimmons M, Wagner M, Soto M, Pham R, Wilson SF, Skiles GL. Subramanian R, et al. Among authors: edson kz. Drug Metab Dispos. 2016 Aug;44(8):1319-31. doi: 10.1124/dmd.115.068007. Epub 2016 Feb 19. Drug Metab Dispos. 2016. PMID: 26895981