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Page 1
Circulating MiR-210 and MiR-1246 as Potential Biomarkers for Differentiating Hepatocellular Carcinoma from Metastatic Tumors in the Liver.
Ahmed EK, Fahmy SA, Effat H, Wahab AHA. Ahmed EK, et al. J Med Biochem. 2019 Mar 3;38(2):109-117. doi: 10.2478/jomb-2018-0010. eCollection 2019 Apr. J Med Biochem. 2019. PMID: 30867638 Free PMC article.
The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as non …
The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, …
Circulating microRNAs as predictive biomarkers for liver disease progression of chronic hepatitis C (genotype-4) Egyptian patients.
El-Hefny M, Fouad S, Hussein T, Abdel-Hameed R, Effat H, Mohamed H, Abdel Wahab AH. El-Hefny M, et al. J Med Virol. 2019 Jan;91(1):93-101. doi: 10.1002/jmv.25294. Epub 2018 Sep 24. J Med Virol. 2019. PMID: 30133717
AST level was directly correlated with miR-122, while an inversely correlated with miR-23b. Fibrosis and steatosis stages possessed positive correlation with miR-199 expression and negative correlation with miR-27a and miR-93. In conclusion, …
AST level was directly correlated with miR-122, while an inversely correlated with miR-23b. Fibrosis and steatosis stages poss …
Functional combination of resveratrol and tamoxifen to overcome tamoxifen-resistance in breast cancer cells.
Radwan AM, Abosharaf HA, Sharaky M, Abdelmonem R, Effat H. Radwan AM, et al. Arch Pharm (Weinheim). 2024 Oct;357(10):e2400261. doi: 10.1002/ardp.202400261. Epub 2024 Jun 29. Arch Pharm (Weinheim). 2024. PMID: 38943449
According to the obtained data, the TAM and RSV combination increased the expression of tumor inhibitor miRNAs such miR-10b-3p, miR-195-3p, and miR-223-3p, which made LCC2 cells more sensitive to TAM. ...
According to the obtained data, the TAM and RSV combination increased the expression of tumor inhibitor miRNAs such miR-10b-3p, mi …
Circulating microRNAs panel as a diagnostic tool for discrimination of HCV-associated hepatocellular carcinoma.
Ali HEA, Abdel Hameed R, Effat H, Ahmed EK, Atef AA, Sharawi SK, Ali M, Abd Elmageed ZY, Abdel Wahab AH. Ali HEA, et al. Clin Res Hepatol Gastroenterol. 2017 Sep;41(4):e51-e62. doi: 10.1016/j.clinre.2017.06.004. Epub 2017 Jul 24. Clin Res Hepatol Gastroenterol. 2017. PMID: 28750770
In this work, circulating microRNAs (miRs) were utilized as a diagnostic tool to test their efficiency to segregate HCC and hepatitis C virus (HCV)-infected patients from healthy subjects. Nine HCC-related miRs (miR-21, miR-30c, miR-93, miR-122, miR …
In this work, circulating microRNAs (miRs) were utilized as a diagnostic tool to test their efficiency to segregate HCC and hepatitis C viru …
The clinical potential of PDL-1 pathway and some related micro-RNAs as promising diagnostic markers for breast cancer.
Al-Sharabass EA, El-Houseini ME, Effat H, Ibrahim SA, Abdellateif MS. Al-Sharabass EA, et al. Mol Med. 2025 Mar 19;31(1):106. doi: 10.1186/s10020-025-01137-1. Mol Med. 2025. PMID: 40108523 Free PMC article.

The sensitivity, specificity, and AUC of miR-155 were 88.9%, 96.7%, and 0.934; respectively (p < 0.001). While those of miR-195 were 73.3%, 60%, and 0.716; respectively (p = 0.001). ...CONCLUSIONS: The PB levels of PDL-1, CTLA-4, PD-1, FOXP3, MIC-B, miR-15

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The sensitivity, specificity, and AUC of miR-155 were 88.9%, 96.7%, and 0.934; respectively (p < 0.001). While those of miR

…
A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells.
Abdel-Wahab AA, Effat H, Mahrous EA, Ali MA, Al-Shafie TA. Abdel-Wahab AA, et al. Nutr Cancer. 2021;73(6):1047-1058. doi: 10.1080/01635581.2020.1783329. Epub 2020 Jun 24. Nutr Cancer. 2021. PMID: 32578448
Second, upregulating tumor suppressor miRNAs; let7a-3p, miR-34c-5p, miR-122-5p, miR-126-3p, miR195-5p, miR-199a-5p, miR-206, and miR-326-5p. ...However, such an extract upregulated oncogenic miRNAs; miR-21, miR-221, and m …
Second, upregulating tumor suppressor miRNAs; let7a-3p, miR-34c-5p, miR-122-5p, miR-126-3p, miR195-5p, miR-199a- …
The Combined Impact of Curcumin: Piperine and Sorafenib on microRNAs and Different Pathways in Breast Cancer Cells.
Effat H, El Houseini ME, Abohashem RS. Effat H, et al. Indian J Clin Biochem. 2025 Jan;40(1):32-45. doi: 10.1007/s12291-024-01212-0. Epub 2024 Apr 18. Indian J Clin Biochem. 2025. PMID: 39835241 Free PMC article.
Molecular genetic analysis revealed that this combination provoked downregulation in oncomirs [miR-21 and miR-155], vimentin, Snail1, Notch, TGF-beta1, Smad4, beta-catenin1 and Wnt10b genes. Meanwhile, there were upregulation of tumor suppressor miRNAs [miR-2 …
Molecular genetic analysis revealed that this combination provoked downregulation in oncomirs [miR-21 and miR-155], vimentin, …