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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.

Toska E, Osmanbeyoglu HU, Castel P, Chan C, Hendrickson RC, Elkabets M, Dickler MN, Scaltriti M, Leslie CS, Armstrong SA, Baselga J. Toska E, et al. Among authors: elkabets m. Science. 2017 Mar 24;355(6331):1324-1330. doi: 10.1126/science.aah6893. Science. 2017. PMID: 28336670 Free PMC article.

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José Baselga M.D., Ph.D. (1959-2021) leading cancer researcher and oncologist.

Elkabets M, Blandino G. Elkabets M, et al. J Exp Clin Cancer Res. 2021 May 7;40(1):156. doi: 10.1186/s13046-021-01966-y. J Exp Clin Cancer Res. 2021. PMID: 33962670 Free PMC article. No abstract available.

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Synthetic promoters to induce immune-effectors into the tumor microenvironment.

Greenshpan Y, Sharabi O, Ottolenghi A, Cahana A, Kundu K, M Yegodayev K, Elkabets M, Gazit R, Porgador A. Greenshpan Y, et al. Among authors: elkabets m. Commun Biol. 2021 Jan 29;4(1):143. doi: 10.1038/s42003-021-01664-7. Commun Biol. 2021. PMID: 33514819 Free PMC article.

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The 4-NQO mouse model: An update on a well-established in vivo model of oral carcinogenesis.

Bouaoud J, De Souza G, Darido C, Tortereau A, Elkabets M, Bertolus C, Saintigny P. Bouaoud J, et al. Among authors: elkabets m. Methods Cell Biol. 2021;163:197-229. doi: 10.1016/bs.mcb.2020.09.004. Epub 2020 Nov 12. Methods Cell Biol. 2021. PMID: 33785166 Review.

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c-Met as a new marker of cellular senescence.

Boichuck M, Zorea J, Elkabets M, Wolfson M, Fraifeld VE. Boichuck M, et al. Among authors: elkabets m. Aging (Albany NY). 2019 May 13;11(9):2889-2897. doi: 10.18632/aging.101961. Aging (Albany NY). 2019. PMID: 31085799 Free PMC article.

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Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs.

Jayaram DR, Frost S, Argov C, Liju VB, Anto NP, Muraleedharan A, Ben-Ari A, Sinay R, Smoly I, Novoplansky O, Isakov N, Toiber D, Keasar C, Elkabets M, Yeger-Lotem E, Livneh E. Jayaram DR, et al. Among authors: elkabets m. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2018899118. doi: 10.1073/pnas.2018899118. Epub 2021 Sep 30. Proc Natl Acad Sci U S A. 2021. PMID: 34593629 Free PMC article.

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Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment.

Castel P, Toska E, Zumsteg ZS, Carmona FJ, Elkabets M, Bosch A, Scaltriti M. Castel P, et al. Among authors: elkabets m. Mol Cell Oncol. 2014 Oct 29;1(3):e963447. doi: 10.4161/23723548.2014.963447. eCollection 2014 Jul-Sep. Mol Cell Oncol. 2014. PMID: 27308344 Free PMC article. Review.

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KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.

Kim JK, Marco MR, Choi SH, Qu X, Chen CT, Elkabets M, Fairchild L, Chow O, Barriga FM, Dow LE, O'Rourke K, Szeglin B, Yarilin D, Fujisawa S, Manova-Todorova K, Paty PB, Shia J, Leslie C, Joshua Smith J, Lowe S, Pelossof R, Sanchez-Vega F, Garcia-Aguilar J. Kim JK, et al. Among authors: elkabets m. Mol Oncol. 2021 Oct;15(10):2766-2781. doi: 10.1002/1878-0261.12960. Epub 2021 Jun 15. Mol Oncol. 2021. PMID: 33817986 Free PMC article.

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BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair.

Zhang S, Peng X, Li X, Liu H, Zhao B, Elkabets M, Liu Y, Wang W, Wang R, Zhong Y, Kong D. Zhang S, et al. Among authors: elkabets m. Cell Death Dis. 2021 May 26;12(6):546. doi: 10.1038/s41419-021-03805-6. Cell Death Dis. 2021. PMID: 34039959 Free PMC article.

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Adaptive Responses to Monotherapy in Head and Neck Cancer: Interventions for Rationale-Based Therapeutic Combinations.

Jagadeeshan S, Prasad M, Ortiz-Cuaran S, Gregoire V, Saintigny P, Elkabets M. Jagadeeshan S, et al. Among authors: elkabets m. Trends Cancer. 2019 Jun;5(6):365-390. doi: 10.1016/j.trecan.2019.04.004. Epub 2019 May 28. Trends Cancer. 2019. PMID: 31208698 Review.

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