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Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.
Xu S, Zhan M, Jiang C, He M, Yang L, Shen H, Huang S, Huang X, Lin R, Shi Y, Liu Q, Chen W, Mohan M, Wang J. Xu S, et al. Nat Commun. 2019 Dec 2;10(1):5492. doi: 10.1038/s41467-019-13420-x. Nat Commun. 2019. PMID: 31792210 Free PMC article. Clinical Trial.
Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in a P53-dependent manner through the Elongator complex and other uridine 34 (U(34)) tRNA-modifying enzymes. ...Downregulated hnRNPQ is unable …
Here, we utilize a genome-wide CRISPR screen to identify that loss of ELP5 reduces the gemcitabine-induced apoptosis in GBC cells in …
DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.
Close P, Gillard M, Ladang A, Jiang Z, Papuga J, Hawkes N, Nguyen L, Chapelle JP, Bouillenne F, Svejstrup J, Fillet M, Chariot A. Close P, et al. J Biol Chem. 2012 Sep 21;287(39):32535-45. doi: 10.1074/jbc.M112.402727. Epub 2012 Aug 1. J Biol Chem. 2012. PMID: 22854966 Free PMC article.
The identity of human ELP1 through ELP4 has been reported but human ELP5 and ELP6 have remained uncharacterized. Here, we report that DERP6 (ELP5) and C3ORF75 (ELP6) encode these subunits of human Elongator. ...Strikingly, DERP6/ELP5 and C3ORF75/ELP6-depleted …
The identity of human ELP1 through ELP4 has been reported but human ELP5 and ELP6 have remained uncharacterized. Here, we report that …
Epigenetic activation of the elongator complex sensitizes gallbladder cancer to gemcitabine therapy.
Xu S, Jiang C, Lin R, Wang X, Hu X, Chen W, Chen X, Chen T. Xu S, et al. J Exp Clin Cancer Res. 2021 Nov 25;40(1):373. doi: 10.1186/s13046-021-02186-0. J Exp Clin Cancer Res. 2021. PMID: 34823564 Free PMC article.
Tissue microarray contains GBC tumour tissues was used to evaluate the association between the expression of ELP5, DNMT3A and PAX5. RESULTS: We demonstrated that transcriptional repression of ELP5 in GBC was highly correlated with hypermethylation of the promoter. M …
Tissue microarray contains GBC tumour tissues was used to evaluate the association between the expression of ELP5, DNMT3A and PAX5. R …
Structural insights into the function of Elongator.
Dalwadi U, Yip CK. Dalwadi U, et al. Cell Mol Life Sci. 2018 May;75(9):1613-1622. doi: 10.1007/s00018-018-2747-6. Epub 2018 Jan 13. Cell Mol Life Sci. 2018. PMID: 29332244 Free PMC article. Review.
Elongator consists of two copies of six core subunits (Elp1, Elp2, Elp3, Elp4, Elp5, and Elp6) that are organized into two subcomplexes: Elp1/2/3 and Elp4/5/6 and form a stable assembly of ~ 850 kDa in size. ...
Elongator consists of two copies of six core subunits (Elp1, Elp2, Elp3, Elp4, Elp5, and Elp6) that are organized into two subcomplex …
Crystal structure of elongator subcomplex Elp4-6.
Lin Z, Zhao W, Diao W, Xie X, Wang Z, Zhang J, Shen Y, Long J. Lin Z, et al. J Biol Chem. 2012 Jun 15;287(25):21501-8. doi: 10.1074/jbc.M112.341560. Epub 2012 May 2. J Biol Chem. 2012. PMID: 22556426 Free PMC article.
The overall structure of Elp4-6 revealed that Elp6 acts as a bridge to assemble Elp4 and Elp5. Detailed structural and sequence analyses revealed that each subunit in the Elp4-6 subcomplex forms a RecA-ATPase-like fold, although it lacks the key sequence signature of ATPas …
The overall structure of Elp4-6 revealed that Elp6 acts as a bridge to assemble Elp4 and Elp5. Detailed structural and sequence analy …
A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes.
Belalcazar LM, Papandonatos GD, McCaffery JM, Peter I, Pajewski NM, Erar B, Allred ND, Balasubramanyam A, Bowden DW, Brautbar A, Pi-Sunyer FX, Ballantyne CM, Huggins GS; Look AHEAD Research Group. Belalcazar LM, et al. Physiol Genomics. 2015 Jun;47(6):215-24. doi: 10.1152/physiolgenomics.00109.2014. Epub 2015 Mar 10. Physiol Genomics. 2015. PMID: 25759378 Free PMC article. Clinical Trial.
A variant, rs222857, in the CLDN7 locus, potentially associated with epithelial barrier integrity and tight junction physiology, and a putative cis expression quantitative trail locus for elongator acetyltransferase complex subunit 5 (ELP5), predicted adiponectin increases …
A variant, rs222857, in the CLDN7 locus, potentially associated with epithelial barrier integrity and tight junction physiology, and a putat …
A comprehensive meta-analysis of transcriptome data to identify signature genes associated with pancreatic ductal adenocarcinoma.
Kordshouli SO, Tahmasebi A, Moghadam A, Ramezani A, Niazi A. Kordshouli SO, et al. PLoS One. 2024 Feb 7;19(2):e0289561. doi: 10.1371/journal.pone.0289561. eCollection 2024. PLoS One. 2024. PMID: 38324544 Free PMC article.
In addition, several hubs in modules were identified, including EMP1, EVL, ELP5, DEF8, MTERF4, GLUP1, CAPN1, IGF1R, HSD17B14, TOM1L2 and RAB11FIP3. According to survival analysis, it was identified that the expression levels of two genes, EMP1 and RAB11FIP3 are related to …
In addition, several hubs in modules were identified, including EMP1, EVL, ELP5, DEF8, MTERF4, GLUP1, CAPN1, IGF1R, HSD17B14, TOM1L2 …
Shared genetic basis and causality between schizophrenia and inflammatory bowel disease: evidence from a comprehensive genetic analysis.
Wang J, Luo GY, Tian T, Zhao YQ, Meng SY, Wu JH, Han WX, Deng B, Ni J. Wang J, et al. Psychol Med. 2024 Jul;54(10):2658-2668. doi: 10.1017/S0033291724000771. Epub 2024 Apr 2. Psychol Med. 2024. PMID: 38563283
Follow-up gene-based analysis found 11 novel pleiotropic genes (KAT5, RABEP1, ELP5, CSNK1G1, etc) in all joint phenotypes. Co-expression and pathway enrichment analysis illustrated those novel genes were mainly involved in core immune-related signal transduction and cerebr …
Follow-up gene-based analysis found 11 novel pleiotropic genes (KAT5, RABEP1, ELP5, CSNK1G1, etc) in all joint phenotypes. Co-express …
Evolutionary Conservation in Protein-Protein Interactions and Structures of the Elongator Sub-Complex ELP456 from Arabidopsis and Yeast.
Jun SE, Cho KH, Schaffrath R, Kim GT. Jun SE, et al. Int J Mol Sci. 2024 Apr 15;25(8):4370. doi: 10.3390/ijms25084370. Int J Mol Sci. 2024. PMID: 38673955 Free PMC article.
In this study, we conducted an in vivo analysis of protein-protein interactions among Arabidopsis ELP4, ELP5, and ELP6 proteins. Additionally, we predicted their structural configurations and performed a comparative analysis with the structure of the yeast Elp456 sub-compl …
In this study, we conducted an in vivo analysis of protein-protein interactions among Arabidopsis ELP4, ELP5, and ELP6 proteins. Addi …
Hearing Function: Identification of New Candidate Genes Further Explaining the Complexity of This Sensory Ability.
Concas MP, Morgan A, Serra F, Nagtegaal AP, Oosterloo BC, Seshadri S, Heard-Costa N, Van Camp G, Fransen E, Francescatto M, Logroscino G, Sardone R, Quaranta N, Gasparini P, Girotto G. Concas MP, et al. Genes (Basel). 2021 Aug 10;12(8):1228. doi: 10.3390/genes12081228. Genes (Basel). 2021. PMID: 34440402 Free PMC article.
Considering expression patterns in humans and mice, eleven genes were considered particularly promising candidates for the hearing function: BNIP3L, ELP5, MAP3K20, MATN2, MTMR7, MYO1E, PCNT, R3HDM1, SLC9A9, TGFB2, and YTHDC2. These findings represent a further contribution …
Considering expression patterns in humans and mice, eleven genes were considered particularly promising candidates for the hearing function: …
21 results