In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan.
Nat Aging. 2022.
PMID: 37118067
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Age-associated clonal B cells drive B cell lymphoma in mice.
Nat Aging. 2024.
PMID: 39117982
Search results
Page 1
Mitotic Dysfunction Associated with Aging Hallmarks.
Adv Exp Med Biol. 2017;1002:153-188. doi: 10.1007/978-3-319-57127-0_7.
Adv Exp Med Biol. 2017.
PMID: 28600786
Review.
Here we review the provocative link between these aging hallmarks and the loss of chromosome segregation fidelity during cell division, which could support the correlation between aging and aneuploidy seen over the past decades. Secondly, we review the systemic impa …
Here we review the provocative link between these aging hallmarks and the loss of chromosome segregation fidelity during cell divisio …
Chromosomal instability and pro-inflammatory response in aging.
Mech Ageing Dev. 2019 Sep;182:111118. doi: 10.1016/j.mad.2019.111118. Epub 2019 May 15.
Mech Ageing Dev. 2019.
PMID: 31102604
Review.
Aging refers to the progressive deterioration of tissue and organ function over time. ...Based on current evidence, we propose that age-associated CIN in mitotically active cells contributes to aging and its associated diseases, and we discuss the inhibition of CIN …
Aging refers to the progressive deterioration of tissue and organ function over time. ...Based on current evidence, we propose that a …
Age-associated clonal B cells drive B cell lymphoma in mice.
Nat Aging. 2024 Oct;4(10):1403-1417. doi: 10.1038/s43587-024-00671-7. Epub 2024 Aug 8.
Nat Aging. 2024.
PMID: 39117982
Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In this study, we uncovered how mouse B cell lymphoma develops as a consequence of a naturally aged system. ...Together, our findings characterize …
Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In thi …
The booming business of hair loss.
Trends Biotechnol. 2023 Jun;41(6):731-735. doi: 10.1016/j.tibtech.2022.12.020. Epub 2023 Jan 18.
Trends Biotechnol. 2023.
PMID: 36669948
Free article.
FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1.
Nat Commun. 2025 Mar 25;16(1):2931. doi: 10.1038/s41467-025-57503-4.
Nat Commun. 2025.
PMID: 40133272
Free PMC article.
Aging is characterized by changes in gene expression, some of which can drive deleterious cellular phenotypes and senescence. The transcriptional activation of senescence genes has been mainly attributed to epigenetic shifts, but the changes in chromatin accessibility and …
Aging is characterized by changes in gene expression, some of which can drive deleterious cellular phenotypes and senescence. The tra …
Misshapen chromosomes in check by mechanics.
Nat Cell Biol. 2025 Jan;27(1):9-11. doi: 10.1038/s41556-024-01573-x.
Nat Cell Biol. 2025.
PMID: 39695243
No abstract available.
Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies.
Int J Mol Sci. 2019 Feb 21;20(4):938. doi: 10.3390/ijms20040938.
Int J Mol Sci. 2019.
PMID: 30795536
Free PMC article.
Review.
Mainstream approaches that are currently used as anti-aging therapies primarily explore the senescence and epigenetic drift aging hallmarks and they are at two ends of the spectrum. ...Moreover, based on recent findings elucidating the impact of mitotic shutdown and …
Mainstream approaches that are currently used as anti-aging therapies primarily explore the senescence and epigenetic drift aging …
The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research.
Stem Cells Transl Med. 2022 Oct 21;11(10):1021-1028. doi: 10.1093/stcltm/szac059.
Stem Cells Transl Med. 2022.
PMID: 35962707
Free PMC article.
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan.
Nat Aging. 2022 May;2(5):397-411. doi: 10.1038/s43587-022-00209-9. Epub 2022 May 5.
Nat Aging. 2022.
PMID: 37118067
Yet, it remains unknown whether increased expression of FOXM1 can delay organismal aging. Here, we show that in vivo cyclic induction of an N-terminal truncated FOXM1 transgene on progeroid and naturally aged mice offsets aging-associated repression of full-length e …
Yet, it remains unknown whether increased expression of FOXM1 can delay organismal aging. Here, we show that in vivo cyclic induction …
FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.
Nat Commun. 2018 Jul 19;9(1):2834. doi: 10.1038/s41467-018-05258-6.
Nat Commun. 2018.
PMID: 30026603
Free PMC article.
Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechanisms remain unknown. ...Based on this feedback loop between cellular aging and aneuploidy, we propose modulation of mitotic efficiency …
Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechani …
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