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3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD. Kulagowski JJ, et al. Among authors: emms f. J Med Chem. 1996 May 10;39(10):1941-2. doi: 10.1021/jm9600712. J Med Chem. 1996. PMID: 8642550 No abstract available.
Functional coupling of human D2, D3, and D4 dopamine receptors in HEK293 cells.
McAllister G, Knowles MR, Ward-Booth SM, Sinclair HA, Patel S, Marwood R, Emms F, Patel S, Smith A, Seabrook GR, et al. McAllister G, et al. Among authors: emms f. J Recept Signal Transduct Res. 1995 Jan-Mar;15(1-4):267-81. doi: 10.3109/10799899509045220. J Recept Signal Transduct Res. 1995. PMID: 8903944
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
Patel S, Freedman S, Chapman KL, Emms F, Fletcher AE, Knowles M, Marwood R, Mcallister G, Myers J, Curtis N, Kulagowski JJ, Leeson PD, Ridgill M, Graham M, Matheson S, Rathbone D, Watt AP, Bristow LJ, Rupniak NM, Baskin E, Lynch JJ, Ragan CI. Patel S, et al. Among authors: emms f. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47. J Pharmacol Exp Ther. 1997. PMID: 9353380
Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore.
McKernan RM, Farrar S, Collins I, Emms F, Asuni A, Quirk K, Broughton H. McKernan RM, et al. Among authors: emms f. Mol Pharmacol. 1998 Jul;54(1):33-43. doi: 10.1124/mol.54.1.33. Mol Pharmacol. 1998. PMID: 9658187
18 results