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257 results

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Page 1
Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint.
Mardjuki R, Wang S, Carozza J, Zirak B, Subramanyam V, Abhiraman G, Lyu X, Goodarzi H, Li L. Mardjuki R, et al. Cell Rep. 2024 May 28;43(5):114209. doi: 10.1016/j.celrep.2024.114209. Epub 2024 May 14. Cell Rep. 2024. PMID: 38749434 Free article.
ENPP3 has a tissue expression pattern distinct from ENPP1's and accounts for all cGAMP hydrolysis activity in ENPP1-deficient mice. ...Our work demonstrates that ENPP1 and ENPP3 non-redundantly dampen extracellular cGAMP-STING signaling, pointing to ENPP3 as …
ENPP3 has a tissue expression pattern distinct from ENPP1's and accounts for all cGAMP hydrolysis activity in ENPP1-deficient mice. . …
IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.
Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, Luengo Sánchez O, Oppenheimer JJ, Jensen-Jarolim E, Fischer DA, Haahtela T, Antila M, Bousquet JJ, Cardona V, Chiang WC, Demoly PM, DuBuske LM, Ferrer Puga M, Gerth van Wijk R, González Díaz SN, Gonzalez-Estrada A, Jares E, Kalpaklioğlu AF, Kase Tanno L, Kowalski ML, Ledford DK, Monge Ortega OP, Morais Almeida M, Pfaar O, Poulsen LK, Pawankar R, Renz HE, Romano AG, Rosário Filho NA, Rosenwasser L, Sánchez Borges MA, Scala E, Senna GE, Sisul JC, Tang MLK, Thong BY, Valenta R, Wood RA, Zuberbier T. Ansotegui IJ, et al. World Allergy Organ J. 2020 Feb 25;13(2):100080. doi: 10.1016/j.waojou.2019.100080. eCollection 2020 Feb. World Allergy Organ J. 2020. PMID: 32128023 Free PMC article.
Dual targeting of ENPP3 and SIRPalpha with a bispecific antibody enhances macrophage-mediated immunity in renal cell carcinoma.
Xu L, Wang S, Li D, Yang B, Zhang J, Ran L, Liu S, Zhang Q, Li B. Xu L, et al. Biochem Biophys Res Commun. 2025 Jul 8;769:151955. doi: 10.1016/j.bbrc.2025.151955. Epub 2025 May 7. Biochem Biophys Res Commun. 2025. PMID: 40349459
Renal cell carcinoma (RCC) remains a therapeutic challenge despite recent immunotherapy advances. We identified ENPP3 and SIRPalpha as significantly overexpressed in RCC tissues with positive correlation and prognostic relevance. Based on these findings, we developed a nov …
Renal cell carcinoma (RCC) remains a therapeutic challenge despite recent immunotherapy advances. We identified ENPP3 and SIRPalpha a …
Divergent splicing factor SRSF1 signaling promotes inflammation post-CME: the SRSF1/ENPP3 axis acts via inhibition of BRD4 O-GlcNAcylation to enhance NF-kappaB activation and accelerate heart failure.
Hu CK, He L, Huang WZ, Huang Y, Dai RX, Chang C, Qiu JX, Wu Q, Su Q. Hu CK, et al. Theranostics. 2025 Jun 9;15(14):6839-6856. doi: 10.7150/thno.115402. eCollection 2025. Theranostics. 2025. PMID: 40585977 Free PMC article.
Knockdown of SRSF1 effectively restrained NF-kappaB-mediated myocardial inflammation through increasing ENPP3 mRNA/lncRNA ENPP3 ratio by regulating alternative splicing of ENPP3 pre-mRNA. The GlcNAcylation of bromodomain-containing protein 4 (BRD4) was reduce …
Knockdown of SRSF1 effectively restrained NF-kappaB-mediated myocardial inflammation through increasing ENPP3 mRNA/lncRNA ENPP3 …
Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates.
Zhao H, Atkinson J, Gulesserian S, Zeng Z, Nater J, Ou J, Yang P, Morrison K, Coleman J, Malik F, Challita-Eid P, Karki S, Aviña H, Hubert R, Capo L, Snyder J, Moon SJ, Luethy R, Mendelsohn BA, Stover DR, Doñate F. Zhao H, et al. Cancer Res. 2018 Apr 15;78(8):2115-2126. doi: 10.1158/0008-5472.CAN-17-3202. Epub 2018 Jan 30. Cancer Res. 2018. PMID: 29382707
AGS-16C3F is an antibody-drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. ...
AGS-16C3F is an antibody-drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMA …
Hypomethylation of the ENPP3 promoter region contributes to the occurrence and development of ovarian endometriosis via the AKT/mTOR/4EBP1 signaling pathway.
Qin Y, Li Y, Hao Y, Li Y, Kang S. Qin Y, et al. Biomol Biomed. 2023 Dec 27;24(4):848-856. doi: 10.17305/bb.2023.9989. Biomol Biomed. 2023. PMID: 38149831 Free PMC article.
This study explores the relationship between abnormal methylation of the ENPP3 promoter and the pathogenesis of ovarian EMs, focusing on its regulatory effect on ENPP3 expression. ...The expression and distribution of ENPP3 were evaluated using RT-qPCR and im …
This study explores the relationship between abnormal methylation of the ENPP3 promoter and the pathogenesis of ovarian EMs, focusing …
ENPP3 drives ccRCC progression by cGAMP hydrolysis and STING-IFN suppression.
Ma J, Wu Y, Lin G, Sun X, Geng H, Zhang T, Yu D. Ma J, et al. Cancer Biol Ther. 2026 Dec 31;27(1):2632995. doi: 10.1080/15384047.2026.2632995. Epub 2026 Feb 19. Cancer Biol Ther. 2026. PMID: 41715305 Free PMC article.
RESULTS: ENPP3 is hypoxia-inducible via HIF-1alpha, upregulated in ccRCC, and predicts poor prognosis. ...The anti-tumor efficacy of ENPP3 blockade was abrogated by IFNAR1 inhibition. CONCLUSION: ENPP3 is a hypoxia-driven, cGAMP-targeting innate immune checkp …
RESULTS: ENPP3 is hypoxia-inducible via HIF-1alpha, upregulated in ccRCC, and predicts poor prognosis. ...The anti-tumor efficacy of …
GRIA2/ENPP3 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells in the Restenosis Process Post-PTA in Lower Extremity Arteries.
Zhou M, Qi L, Gu Y. Zhou M, et al. Front Physiol. 2021 Aug 24;12:712400. doi: 10.3389/fphys.2021.712400. eCollection 2021. Front Physiol. 2021. PMID: 34504438 Free PMC article.
Using Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and protein-protein interaction (PPI) network, a strong connection between ENPP3 and GRIA2 was discovered. In vitro results showed that the high expression of GRIA2 in VSMCs enhanced the expression of …
Using Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and protein-protein interaction (PPI) network, a strong connection …
Identification of extracellular membrane protein ENPP3 as a major cGAMP hydrolase, cementing cGAMP's role as an immunotransmitter.
Mardjuki R, Wang S, Carozza JA, Abhiraman GC, Lyu X, Li L. Mardjuki R, et al. bioRxiv [Preprint]. 2024 Jan 13:2024.01.12.575449. doi: 10.1101/2024.01.12.575449. bioRxiv. 2024. Update in: Cell Rep. 2024 May 28;43(5):114209. doi: 10.1016/j.celrep.2024.114209. PMID: 38260585 Free PMC article. Updated. Preprint.
ENPP3 has a tissue expression pattern distinct from that of ENPP1 and accounts for all remaining cGAMP hydrolysis activity in mice lacking ENPP1. ...Our work clearly shows that ENPP1 and ENPP3 non-redundantly dampen extracellular cGAMP-STING signaling, pointing to …
ENPP3 has a tissue expression pattern distinct from that of ENPP1 and accounts for all remaining cGAMP hydrolysis activity in mice la …
Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation.
Chen Q, Xin A, Qu R, Zhang W, Li L, Chen J, Lu X, Gu Y, Li J, Sun X. Chen Q, et al. Reprod Fertil Dev. 2018 Oct;30(10):1277-1285. doi: 10.1071/RD17257. Reprod Fertil Dev. 2018. PMID: 29614240
ENPP3 expression was analysed using immunohistochemistry and western blot assay. The effects of ENPP3 on embryo implantation were evaluated using a BeWo cell (a human choriocarcinoma cell line) spheroid attachment assay and BeWo cells were dual cultured with Ishikaw …
ENPP3 expression was analysed using immunohistochemistry and western blot assay. The effects of ENPP3 on embryo implantation w …
257 results