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86 results

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Page 1
Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.
Thomas MF, L'Etoile ND, Ansel KM. Thomas MF, et al. Trends Genet. 2014 Jul;30(7):298-307. doi: 10.1016/j.tig.2014.05.003. Epub 2014 Jun 12. Trends Genet. 2014. PMID: 24929628 Free PMC article. Review.
Eri1 is an evolutionarily conserved 3'-5' exoribonuclease that participates in 5.8S rRNA 3' end processing and turnover of replication-dependent histone mRNAs. ...We summarize recent advances in the understanding of Eri1 function in these pathways and discuss how …
Eri1 is an evolutionarily conserved 3'-5' exoribonuclease that participates in 5.8S rRNA 3' end processing and turnover of replicatio …
Congenital Bone Disorders Associated with ERI1-Mediated RNA Metabolism Dysfunction: Spondylo-Epi-Metaphyseal Dysplasia Guo-Campeau Type and Beyond.
Liu W, Zhu J, Ren K, Xiao D, Qiang R, Rabouhi N, Ikegawa S, Campeau PM, Guo L. Liu W, et al. Curr Osteoporos Rep. 2025 Feb 13;23(1):9. doi: 10.1007/s11914-025-00903-8. Curr Osteoporos Rep. 2025. PMID: 39945916 Review.
PURPOSE OF REVIEW: The purpose of this review is to explore the multifaceted roles of the ERI1 exoribonuclease, particularly in RNA metabolism and bone development, and to address the genotype-phenotype complexity in patients and mice with ERI1 pathogenic variants. …
PURPOSE OF REVIEW: The purpose of this review is to explore the multifaceted roles of the ERI1 exoribonuclease, particularly in RNA m …
ERI1: A case report of an autosomal recessive syndrome associated with developmental delay and distal limb abnormalities.
Hoxha V, Aliu E. Hoxha V, et al. Am J Med Genet A. 2023 Jan;191(1):64-69. doi: 10.1002/ajmg.a.62987. Epub 2022 Oct 8. Am J Med Genet A. 2023. PMID: 36208065
ERI1 is an evolutionary conserved 3'-5' exonuclease with an important function in multiple RNA processing pathways. Although the molecular mechanisms in which ERI1 is involved have been studied extensively in model organisms, the pathology associated with ERI1 …
ERI1 is an evolutionary conserved 3'-5' exonuclease with an important function in multiple RNA processing pathways. Although the mole …
Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.
Guo L, Salian S, Xue JY, Rath N, Rousseau J, Kim H, Ehresmann S, Moosa S, Nakagawa N, Kuroda H, Clayton-Smith J, Wang J, Wang Z, Banka S, Jackson A, Zhang YM, Wei ZJ, Hüning I, Brunet T, Ohashi H, Thomas MF, Bupp C, Miyake N, Matsumoto N, Mendoza-Londono R, Costain G, Hahn G, Di Donato N, Yigit G, Yamada T, Nishimura G, Ansel KM, Wollnik B, Hrabě de Angelis M, Mégarbané A, Rosenfeld JA, Heissmeyer V, Ikegawa S, Campeau PM. Guo L, et al. Am J Hum Genet. 2023 Jul 6;110(7):1068-1085. doi: 10.1016/j.ajhg.2023.06.001. Epub 2023 Jun 22. Am J Hum Genet. 2023. PMID: 37352860 Free PMC article.
ERI1 is a 3'-to-5' exoribonuclease involved in RNA metabolic pathways including 5.8S rRNA processing and turnover of histone mRNAs. ...The ERI1 missense variants cause a loss of the exoribonuclease activity, leading to defective trimming of the 5.8S rRNA 3' end and …
ERI1 is a 3'-to-5' exoribonuclease involved in RNA metabolic pathways including 5.8S rRNA processing and turnover of histone mRNAs. . …
Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function.
Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM. Thomas MF, et al. Blood. 2012 Jul 5;120(1):130-42. doi: 10.1182/blood-2011-11-394072. Epub 2012 May 21. Blood. 2012. PMID: 22613798 Free PMC article.
Eri1 was required for immune-mediated control of mouse CMV (MCMV) infection. Ly49H(+) NK cells deficient in Eri1 failed to expand efficiently during MCMV infection, and virus-specific responses were also diminished among Eri1(-/-) T cells. ...Ectopic Eri1 …
Eri1 was required for immune-mediated control of mouse CMV (MCMV) infection. Ly49H(+) NK cells deficient in Eri1 failed to exp …
Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.
Declercq M, Biquand E, Karim M, Pietrosemoli N, Jacob Y, Demeret C, Barbezange C, van der Werf S. Declercq M, et al. Nucleic Acids Res. 2020 Oct 9;48(18):10428-10440. doi: 10.1093/nar/gkaa771. Nucleic Acids Res. 2020. PMID: 32960265 Free PMC article.
Here, using a stringent interactomics screening strategy and an siRNA-silencing approach, we identified eight cellular factors among a set of 75 cellular proteins carrying exo(ribo)nuclease activities or involved in RNA decay processes that support influenza A virus multiplicatio …
Here, using a stringent interactomics screening strategy and an siRNA-silencing approach, we identified eight cellular factors among a set o …
Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.
Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V. Hoefig KP, et al. Nat Struct Mol Biol. 2013 Jan;20(1):73-81. doi: 10.1038/nsmb.2450. Epub 2012 Dec 2. Nat Struct Mol Biol. 2013. PMID: 23202588
The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the functional importance of this interaction remains elusive. Histone mRNAs are normally degraded at the end of S phase or after pharmacologica …
The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the …
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.
Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V. Ansel KM, et al. Nat Struct Mol Biol. 2008 May;15(5):523-30. doi: 10.1038/nsmb.1417. Epub 2008 Apr 27. Nat Struct Mol Biol. 2008. PMID: 18438418 Free PMC article.
Eri1 is a 3'-to-5' exoribonuclease conserved from fission yeast to humans. Here we show that Eri1 associates with ribosomes and ribosomal RNA (rRNA). Ribosomes from Eri1-deficient mice contain 5.8S rRNA that is aberrantly extended at its 3' end, and Eri1 …
Eri1 is a 3'-to-5' exoribonuclease conserved from fission yeast to humans. Here we show that Eri1 associates with ribosomes an …
The ER-Resident Ras Inhibitor 1 (Eri1) of Candida albicans Inhibits Hyphal Morphogenesis via the Ras-Independent cAMP-PKA Pathway.
Sethi SC, Bharati M, Kumar Y, Yadav U, Saini H, Alam P, Komath SS. Sethi SC, et al. ACS Infect Dis. 2024 Oct 11;10(10):3528-3543. doi: 10.1021/acsinfecdis.4c00175. Epub 2024 Aug 9. ACS Infect Dis. 2024. PMID: 39119676
The inhibition is mediated via an interaction of yeast Ras2 with the Eri1 subunit of its GPI-N-acetylglucosaminyl transferase (GPI-GnT), the enzyme catalyzing the very first GPI biosynthetic step. In contrast, Ras signaling and GPI biosynthesis in C. albicans (Ca) are mutu …
The inhibition is mediated via an interaction of yeast Ras2 with the Eri1 subunit of its GPI-N-acetylglucosaminyl transferase (GPI-Gn …
A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum.
Sobering AK, Romeo MJ, Vay HA, Levin DE. Sobering AK, et al. Mol Cell Biol. 2003 Jul;23(14):4983-90. doi: 10.1128/MCB.23.14.4983-4990.2003. Mol Cell Biol. 2003. PMID: 12832483 Free PMC article.
ERI1 encodes a 68-amino-acid protein that associates in vivo with GTP-bound Ras in a manner that requires an intact Ras-effector loop, suggesting that Eri1 competes for the same binding site as Ras target proteins. We show that Eri1 localizes primarily to the …
ERI1 encodes a 68-amino-acid protein that associates in vivo with GTP-bound Ras in a manner that requires an intact Ras-effector loop …
86 results