Systematically evaluating DOTATATE and FDG as PET immuno-imaging tracers of cardiovascular inflammation.
Toner YC, Ghotbi AA, Naidu S, Sakurai K, van Leent MMT, Jordan S, Ordikhani F, Amadori L, Sofias AM, Fisher EL, Maier A, Sullivan N, Munitz J, Senders ML, Mason C, Reiner T, Soultanidis G, Tarkin JM, Rudd JHF, Giannarelli C, Ochando J, Pérez-Medina C, Kjaer A, Mulder WJM, Fayad ZA, Calcagno C.
Toner YC, et al.
Sci Rep. 2022 Apr 13;12(1):6185. doi: 10.1038/s41598-022-09590-2.
Sci Rep. 2022.
PMID: 35418569
Free PMC article.
In both models, [(64)Cu]Cu-DOTATATE demonstrated preferential accumulation in macrophages with respect to other myeloid cells, while [(18)F]F-FDG was taken up by macrophages and other leukocytes. In a translational PET/MRI study in atherosclerotic rabbits, we then c …
In both models, [(64)Cu]Cu-DOTATATE demonstrated preferential accumulation in macrophages with respect to other myeloid cells, while [(18) …