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Bioassay-guided isolation of anti-hepatitis B virus flavonoid myricetin-3-O-rhamnoside along with quercetin from Guiera senegalensis leaves.
Parvez MK, Al-Dosari MS, Arbab AH, Al-Rehaily AJ, Abdelwahid MAS. Parvez MK, et al. Saudi Pharm J. 2020 May;28(5):550-559. doi: 10.1016/j.jsps.2020.03.006. Epub 2020 Mar 19. Saudi Pharm J. 2020. PMID: 32435135 Free PMC article.
The two isolated bioactive compounds were identified as quercetin and myricetin-3-O-rhamnoside. Quercetin significantly inhibited synthesis of HBsAg and HBeAg by about 60% and 62%, respectively as compared to myricetin-3-O-rhamnoside by 44% and 35%, respectively. .. …
The two isolated bioactive compounds were identified as quercetin and myricetin-3-O-rhamnoside. Quercetin significantly inhibited syn …
Ketamine-based Sedation Use in Mechanically Ventilated Critically Ill Patients with COVID-19: A Multicenter Cohort Study.
Aljuhani O, Al Sulaiman K, Korayem GB, Altebainawi AF, Alshaya A, Nahari M, Alsamnan K, Alkathiri MA, Al-Dosari BS, Alenazi AA, Alsohimi S, Alnajjar LI, Alfaifi M, AlQussair N, Alanazi RM, Alhmoud MF, Alanazi NL, Alkofide H, Alenezi AM, Vishwakarma R. Aljuhani O, et al. Saudi Pharm J. 2024 May;32(5):102061. doi: 10.1016/j.jsps.2024.102061. Epub 2024 Apr 3. Saudi Pharm J. 2024. PMID: 38596319 Free PMC article.
The primary outcome was the length of stay (LOS) in the hospital. P/F ratio differences, lactic acid normalization, MV duration, and mortality were considered secondary outcomes. ...
The primary outcome was the length of stay (LOS) in the hospital. P/F ratio differences, lactic acid normalization, MV duration, and …
Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cell lines.
Zaki RM, Alkharashi LA, Sarhan OM, Almurshedi AS, Aldosari BN, Said M. Zaki RM, et al. Int J Pharm X. 2023 Aug 25;6:100208. doi: 10.1016/j.ijpx.2023.100208. eCollection 2023 Dec 15. Int J Pharm X. 2023. PMID: 37680878 Free PMC article.
The formulation variables were glyceryl monooleate concentration (GMO) w/w%, Pluronic F-127 concentration (PF127) w/w% and Tween 80 concentration w/w% whereas Entrapment efficiency (EE%), Vesicles' size (VS) and Zeta potential (ZP) were set as the dependent responses. ...
The formulation variables were glyceryl monooleate concentration (GMO) w/w%, Pluronic F-127 concentration (PF127) w/w% and Tween 80 c …
Cell proliferation activity delineated by molecular docking of four new compounds isolated from the aerial parts of Suaeda monoica Forssk. ex. J.F. Gmel.
Siddiqui NA, Mothana RA, Al-Said MS, Parvez MK, Alam P, Tabish Rehman M, Ali M, Alajmi MF, Al-Dosari MS, Al-Rehaily AJ, Nasr FA, Khalid JM. Siddiqui NA, et al. Saudi Pharm J. 2020 Feb;28(2):172-186. doi: 10.1016/j.jsps.2019.11.019. Epub 2019 Dec 7. Saudi Pharm J. 2020. PMID: 32042256 Free PMC article.
The structures of the new compounds were established as 6'-hydroxy-10'-geranilanyl naphtha-1-oate (SMC-1), 4,4,8beta,10beta-Tetramethyl-9beta-isobutanyl decalin-13-ol-13-O-beta-D-xylopyranoside (SCM-2), 6'-(2-hydroxynaphthalen-3-yl) hexanoic acid (SCM-4) and 1'-(2-Methoxy- …
The structures of the new compounds were established as 6'-hydroxy-10'-geranilanyl naphtha-1-oate (SMC-1), 4,4,8beta,10beta-Tetramethyl-9bet …
Quantification of glycyrrhizin in anti-stress herbal formulations by validate HPTLC method: a rational paradigm towards quality control of herbals.
Siddiqui NA, Alam P, Parvez MK, Basudan OA, Al-Dosari MS, Al-Rehaily AJ, Al-Ajmi MF, Shakeel F. Siddiqui NA, et al. Pak J Pharm Sci. 2015 Jan;28(1 Suppl):353-7. Pak J Pharm Sci. 2015. PMID: 25631512
Chromatography was performed by using mobile phase ethyl acetate (EA): glacial acetic acid (GAA): Methanol (MeOH): water (H(2)O) in proportion of 6:2:2:1, v/v/v/v. The developed plate was scanned and quantified densitometrically at absorption maxima 254nm. ...The developed …
Chromatography was performed by using mobile phase ethyl acetate (EA): glacial acetic acid (GAA): Methanol (MeOH): water (H(2)O) in p …