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Robust and Facile Automated Radiosynthesis of [(18)F]FSPG on the GE FASTlab.
Edwards R, Greenwood HE, McRobbie G, Khan I, Witney TH. Edwards R, et al. Among authors: khan i. Mol Imaging Biol. 2021 Dec;23(6):854-864. doi: 10.1007/s11307-021-01609-w. Epub 2021 May 20. Mol Imaging Biol. 2021. PMID: 34013395 Free PMC article.
PURPOSE: (S)-4-(3-(18)F-Fluoropropyl)-L-Glutamic Acid ([(18)F]FSPG) is a radiolabeled non-natural amino acid that is used for positron emission tomography (PET) imaging of the glutamate/cystine antiporter, system x(C)(-), whose expression is upregulated in many canc …
PURPOSE: (S)-4-(3-(18)F-Fluoropropyl)-L-Glutamic Acid ([(18)F]FSPG) is a radiolabeled non-natural amino acid that is used for …
c-Met PET Imaging Detects Early-Stage Locoregional Recurrence of Basal-Like Breast Cancer.
Arulappu A, Battle M, Eisenblaetter M, McRobbie G, Khan I, Monypenny J, Weitsman G, Galazi M, Hoppmann S, Gazinska P, Wulaningsih W, Dalsgaard GT, Macholl S, Ng T. Arulappu A, et al. Among authors: khan i. J Nucl Med. 2016 May;57(5):765-70. doi: 10.2967/jnumed.115.164384. Epub 2015 Dec 3. J Nucl Med. 2016. PMID: 26635342 Free article.
CT images and caliper were used to determine the tumor volume. Radiotracer uptake was assessed by (18)F-AH113804 PET imaging. c-Met expression was assessed by immunofluorescence imaging of tumor samples and correlated with (18)F-AH113804 PET imaging results. ...The …
CT images and caliper were used to determine the tumor volume. Radiotracer uptake was assessed by (18)F-AH113804 PET imaging. c-Met e …
Optimization of preoxidation to reduce scaling during cleaning-in-place of membrane treatment.
Khan IA, Lee YS, Kim JO. Khan IA, et al. J Hazard Mater. 2020 Dec 5;400:123212. doi: 10.1016/j.jhazmat.2020.123212. Epub 2020 Jun 17. J Hazard Mater. 2020. PMID: 32947743
Fourier-transform infrared spectroscopy revealed changes in CCl and C-F functional groups, with bond vibrations at 542 cm(-1) and 1199 cm(-1), respectively. ...
Fourier-transform infrared spectroscopy revealed changes in CCl and C-F functional groups, with bond vibrations at 542 cm(-1) and 119 …
Biorational Control of Callosobruchus maculatus (Coleoptera: Buchidae) in Stored Grains with Botanical Extracts.
Akbar R, Khan IA, Faheem B, Azad R, Zaman M, Altaf R, Usman A, Fawad M, Farid A, Saljoqi AUR, Syed A, Bahkali AH, Elgorban AM, Shah JA, Qayyum A. Akbar R, et al. Among authors: khan ia. Biomed Res Int. 2022 Aug 29;2022:3443578. doi: 10.1155/2022/3443578. eCollection 2022. Biomed Res Int. 2022. Retraction in: Biomed Res Int. 2024 Jan 9;2024:9861621. doi: 10.1155/2024/9861621. PMID: 36072466 Free PMC article. Retracted.
Therefore, the current study was carried out to investigate the repellency potential of five botanicals against Callosbruchus maculatus F. in Haripur, Pakistan. The concentrations of Azadirachta indica L., Nicotiana tabacum L., Melia azedarach L., Nicotiana rustica L., and …
Therefore, the current study was carried out to investigate the repellency potential of five botanicals against Callosbruchus maculatus F …
Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy.
Zaib S, Rana N, Hussain N, Ogaly HA, Dera AA, Khan I. Zaib S, et al. Among authors: khan i. Molecules. 2023 Mar 14;28(6):2623. doi: 10.3390/molecules28062623. Molecules. 2023. PMID: 36985595 Free PMC article.
Afterward, the interactions between target and ligands were investigated using Discovery Studio. Ultimately, compounds c and f were identified as potent inhibitors of 4-hydroxyphenylpyruvate dioxygenase....
Afterward, the interactions between target and ligands were investigated using Discovery Studio. Ultimately, compounds c and f were i …
Rapid Aqueous Late-Stage Radiolabelling of [GaF(3) (BnMe(2) -tacn)] by (18) F/(19) F Isotopic Exchange: Towards New PET Imaging Probes.
Monzittu FM, Khan I, Levason W, Luthra SK, McRobbie G, Reid G. Monzittu FM, et al. Among authors: khan i. Angew Chem Int Ed Engl. 2018 May 28;57(22):6658-6661. doi: 10.1002/anie.201802446. Epub 2018 Apr 26. Angew Chem Int Ed Engl. 2018. PMID: 29659110 Free PMC article.
A simple and rapid method for (18) F radiolabelling of [GaF(3) (BnMe(2) -tacn)] by (18) F/(19) F isotopic exchange is described. The use of MeCN/H(2) O or EtOH/H(2) O (75:25) and aqueous [(18) F]F(-) (up to 200 MBq) with heating (80 C, 10 min) g …
A simple and rapid method for (18) F radiolabelling of [GaF(3) (BnMe(2) -tacn)] by (18) F/(19) F isotopic exchange is d …
A Resin-linker-vector approach to radiopharmaceuticals containing 18F: application in the synthesis of O-(2-[18F]-fluoroethyl)-L-tyrosine.
Topley AC, Isoni V, Logothetis TA, Wynn D, Wadsworth H, Gibson AM, Khan I, Wells NJ, Perrio C, Brown RC. Topley AC, et al. Among authors: khan i. Chemistry. 2013 Jan 28;19(5):1720-5. doi: 10.1002/chem.201202474. Epub 2012 Dec 19. Chemistry. 2013. PMID: 23255371
On fluoridolysis, the RLVs 8a,b containing the longer spacers were shown to be more effective in the release of the fluorinated model vector (4-fluorobutyl)phenylcarbamic acid tert-butyl ester (9) in NMR kinetic studies and gave superior radiochemical yields (RCY60%) of the (18) …
On fluoridolysis, the RLVs 8a,b containing the longer spacers were shown to be more effective in the release of the fluorinated model vector …
[¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging Translocator protein 18 kDa (TSPO).
Wadsworth H, Jones PA, Chau WF, Durrant C, Fouladi N, Passmore J, O'Shea D, Wynn D, Morisson-Iveson V, Ewan A, Thaning M, Mantzilas D, Gausemel I, Khan I, Black A, Avory M, Trigg W. Wadsworth H, et al. Among authors: khan i. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1308-13. doi: 10.1016/j.bmcl.2011.12.084. Epub 2011 Dec 27. Bioorg Med Chem Lett. 2012. PMID: 22244939
Evaluation in an autoradiography model of neuroinflammation was also carried out for the best compound, 12a ([(18)F]GE-180)....
Evaluation in an autoradiography model of neuroinflammation was also carried out for the best compound, 12a ([(18)F]GE-180)....
Optimization of membrane modification using SiO2 for robust anti-fouling performance with calcium-humic acid feed in membrane distillation.
Khan AA, Khan IA, Siyal MI, Lee CK, Kim JO. Khan AA, et al. Among authors: khan ia. Environ Res. 2019 Mar;170:374-382. doi: 10.1016/j.envres.2018.12.036. Epub 2018 Dec 18. Environ Res. 2019. PMID: 30623884
Scanning electron microscopy (SEM) analysis confirmed the SiO(2) deposition and Fourier-transform infrared spectroscopy (FTIR) test evidenced the new functional groups i.e., Si-OH, siloxane, and C-F bond vibrations at 3446, 1099 cm(-1), and 1150-1240 cm(-1) respectively on …
Scanning electron microscopy (SEM) analysis confirmed the SiO(2) deposition and Fourier-transform infrared spectroscopy (FTIR) test evidence …
Synthesis and in vitro evaluation of (18)F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET.
Robins EG, Zhao Y, Khan I, Wilson A, Luthra SK, Rstad E. Robins EG, et al. Among authors: khan i. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1749-51. doi: 10.1016/j.bmcl.2010.01.052. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20138515
Two S-[(18)F]fluoroalkylated diarylguanidines were synthesized and evaluated in vitro as potential tracers for imaging of N-methyl-d-aspartate receptors (NMDARs) with positron emission tomography (PET). [(18)F]1 and [(18)F]10 were synthesized by [(18)F …
Two S-[(18)F]fluoroalkylated diarylguanidines were synthesized and evaluated in vitro as potential tracers for imaging of N-methyl-d- …
19 results