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Year Number of Results
2006 1
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55 results

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Page 1
Fumarate induces vesicular release of mtDNA to drive innate immunity.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel IMN, Morris JL, Ferguson A, Chowdury SR, Segarra-Mondejar M, Costa ASH, Pereira GC, Tronci L, Young T, Nikitopoulou E, Yang M, Bihary D, Caicci F, Nagashima S, Speed A, Bokea K, Baig Z, Samarajiwa S, Tran M, Mitchell T, Johnson M, Prudent J, Frezza C. Zecchini V, et al. Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8. Nature. 2023. PMID: 36890229 Free PMC article.
Type I IFN drives unconventional IL-1β secretion in lupus monocytes.
Caielli S, Balasubramanian P, Rodriguez-Alcazar J, Balaji U, Robinson L, Wan Z, Baisch J, Smitherman C, Walters L, Sparagana P, Nehar-Belaid D, Marches R, Nassi L, Stewart K, Fuller J, Banchereau JF, Gu J, Wright T, Pascual V. Caielli S, et al. Immunity. 2024 Nov 12;57(11):2497-2513.e12. doi: 10.1016/j.immuni.2024.09.004. Epub 2024 Oct 7. Immunity. 2024. PMID: 39378884 Free PMC article.
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors.
Laliberté A, Prelli Bozzo C, Acharya D, De Luna A, Hirschenberger M, Zhu J, Volcic M, Stolp B, Rodriguez-Quinteros CM, Fackler OT, Gack MU, Sparrer KMJ, Kirchhoff F. Laliberté A, et al. Nat Commun. 2025 Dec 7;16(1):10945. doi: 10.1038/s41467-025-67028-5. Nat Commun. 2025. PMID: 41354661 Free PMC article.
HIV-1 variants containing single point mutations in Nef (F/R191A) that ablate its ability to bind the actin-modulating kinase PAK2 trigger increased interferon (IFN) responses in primary CD4(+) T cells, macrophages, and dendritic cells. ...We further demonstrate that HIV-1 …
HIV-1 variants containing single point mutations in Nef (F/R191A) that ablate its ability to bind the actin-modulating kinase PAK2 tr …
Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10.
Mah MM, Roverato N, Groettrup M. Mah MM, et al. Biomolecules. 2020 Jun 23;10(6):951. doi: 10.3390/biom10060951. Biomolecules. 2020. PMID: 32586037 Free PMC article. Review.
The revelation that the human major histocompatibility complex (MHC) class I locus encodes a ubiquitin-like protein designated HLA-F adjacent transcript 10 (FAT10) or ubiquitin D (UBD) has attracted increasing attention to the function of this protein. ...
The revelation that the human major histocompatibility complex (MHC) class I locus encodes a ubiquitin-like protein designated HLA-F …
IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Guney MH, Nagalekshmi K, McCauley SM, Carbone C, Aydemir O, Luban J. Guney MH, et al. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2404349121. doi: 10.1073/pnas.2404349121. Epub 2024 Jul 10. Proc Natl Acad Sci U S A. 2024. PMID: 38985764 Free PMC article.
Finally, specific enrichment of unspliced HIV-1 RNA by IFIH1 (MDA5), over two orders of magnitude, was revealed by formaldehyde cross-linking immunoprecipitation (f-CLIP). These results demonstrate that IFIH1 is the innate immune receptor for intron-containing RNA from the …
Finally, specific enrichment of unspliced HIV-1 RNA by IFIH1 (MDA5), over two orders of magnitude, was revealed by formaldehyde cross-linkin …
55 results