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Page 1
FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells.
Xu W, Yang Y, Yu Y, Wen C, Zhao S, Cao L, Zhao S, Qin Y, Chen ZJ. Xu W, et al. BMC Biol. 2023 Aug 15;21(1):174. doi: 10.1186/s12915-023-01676-1. BMC Biol. 2023. PMID: 37580696 Free PMC article.
FAAP100 deletion leads to FA pathway inactivation, increases TRCs as well as cotranscriptional R-loops, and contributes to the collapse of replication forks and the generation of DNA damage. ...CONCLUSIONS: Our findings suggest that FAAP100 is required for the resol …
FAAP100 deletion leads to FA pathway inactivation, increases TRCs as well as cotranscriptional R-loops, and contributes to the collap …
Fanconi Anemia.
Mehta PA, Ebens C. Mehta PA, et al. 2002 Feb 14 [updated 2021 Jun 3]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2002 Feb 14 [updated 2021 Jun 3]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301575 Free Books & Documents. Review.
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.
Ling C, Ishiai M, Ali AM, Medhurst AL, Neveling K, Kalb R, Yan Z, Xue Y, Oostra AB, Auerbach AD, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Takata M, Meetei AR, Wang W. Ling C, et al. EMBO J. 2007 Apr 18;26(8):2104-14. doi: 10.1038/sj.emboj.7601666. Epub 2007 Mar 29. EMBO J. 2007. PMID: 17396147 Free PMC article.
Here, we report a novel component of this complex, termed FAAP100, which is essential for the stability of the core complex and directly interacts with FANCB and FANCL to form a stable subcomplex. ...Our study identifies FAAP100 as a new critical component of the FA …
Here, we report a novel component of this complex, termed FAAP100, which is essential for the stability of the core complex and direc …
Structure of the Fanconi anaemia monoubiquitin ligase complex.
Shakeel S, Rajendra E, Alcón P, O'Reilly F, Chorev DS, Maslen S, Degliesposti G, Russo CJ, He S, Hill CH, Skehel JM, Scheres SHW, Patel KJ, Rappsilber J, Robinson CV, Passmore LA. Shakeel S, et al. Nature. 2019 Nov;575(7781):234-237. doi: 10.1038/s41586-019-1703-4. Epub 2019 Oct 30. Nature. 2019. PMID: 31666700 Free PMC article.
The FA core complex comprises two central dimers of the FANCB and FA-associated protein of 100 kDa (FAAP100) subunits, flanked by two copies of the RING finger subunit, FANCL. These two heterotrimers act as a scaffold to assemble the remaining five subunits, resulting in a …
The FA core complex comprises two central dimers of the FANCB and FA-associated protein of 100 kDa (FAAP100) subunits, flanked by two …
FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA.
Ali AM, Singh TR, Meetei AR. Ali AM, et al. Mutat Res. 2009 Jul 31;668(1-2):20-6. doi: 10.1016/j.mrfmmm.2009.04.002. Epub 2009 Apr 18. Mutat Res. 2009. PMID: 19379763 Free PMC article. Review.
Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear core complex that is required for monoubiquitination of the FANCD2-FANCI dimer upon DNA damage. ...
Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear cor …
The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.
Swuec P, Renault L, Borg A, Shah F, Murphy VJ, van Twest S, Snijders AP, Deans AJ, Costa A. Swuec P, et al. Cell Rep. 2017 Jan 17;18(3):611-623. doi: 10.1016/j.celrep.2016.11.013. Epub 2016 Dec 13. Cell Rep. 2017. PMID: 27986592 Free PMC article.
FANCD2 mono-ubiquitination by FANCL is stimulated by the presence of the FANCB and FAAP100 core complex components, through an unknown mechanism. How FANCI mono-ubiquitination is achieved remains unclear. ...The FANCC-FANCE-FANCF subunits bridge between FANCB-FANCL-FAAP …
FANCD2 mono-ubiquitination by FANCL is stimulated by the presence of the FANCB and FAAP100 core complex components, through an unknow …
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.
Thompson LH, Hinz JM. Thompson LH, et al. Mutat Res. 2009 Jul 31;668(1-2):54-72. doi: 10.1016/j.mrfmmm.2009.02.003. Epub 2009 Feb 21. Mutat Res. 2009. PMID: 19622404 Free PMC article. Review.
The FANC core subcomplex (FANCA, B, C, E, F, G, L, FAAP100) promotes TLS for both crosslink and non-crosslink damage such as spontaneous oxidative base damage, UV-C photoproducts, and alkylated bases. ...
The FANC core subcomplex (FANCA, B, C, E, F, G, L, FAAP100) promotes TLS for both crosslink and non-crosslink damage such as spontane …
The genetic and biochemical basis of FANCD2 monoubiquitination.
Rajendra E, Oestergaard VH, Langevin F, Wang M, Dornan GL, Patel KJ, Passmore LA. Rajendra E, et al. Mol Cell. 2014 Jun 5;54(5):858-69. doi: 10.1016/j.molcel.2014.05.001. Mol Cell. 2014. PMID: 24905007 Free PMC article.
We genetically and biochemically define a minimal subcomplex comprising just three proteins (FANCB, FANCL, and FAAP100) that functions as the monoubiquitination module. Residual FANCD2 monoubiquitination activity is retained in cells defective for other FA core complex sub …
We genetically and biochemically define a minimal subcomplex comprising just three proteins (FANCB, FANCL, and FAAP100) that function …
Modularized functions of the Fanconi anemia core complex.
Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Huang Y, et al. Cell Rep. 2014 Jun 26;7(6):1849-57. doi: 10.1016/j.celrep.2014.04.029. Epub 2014 Jun 5. Cell Rep. 2014. PMID: 24910428 Free PMC article.
Through epistasis analyses, we identify three functional modules in the FA core complex: a catalytic module consisting of FANCL, FANCB, and FAAP100 is absolutely required for the E3 ligase function, and the FANCA-FANCG-FAAP20 and the FANCC-FANCE-FANCF modules provide nonre …
Through epistasis analyses, we identify three functional modules in the FA core complex: a catalytic module consisting of FANCL, FANCB, and …
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.
Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Leung JW, et al. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4491-6. doi: 10.1073/pnas.1118720109. Epub 2012 Mar 6. Proc Natl Acad Sci U S A. 2012. PMID: 22396592 Free PMC article.
The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core complex has ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID) complex, which in turn initiates a cascade of bi …
The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core comple …
15 results