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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 3
1976 1
1978 1
1980 1
1983 1
1985 1
1986 2
1990 1
1992 2
1993 2
1994 2
1995 4
1996 24
1997 38
1998 75
1999 103
2000 128
2001 190
2002 190
2003 207
2004 212
2005 206
2006 202
2007 231
2008 207
2009 223
2010 219
2011 204
2012 190
2013 210
2014 193
2015 195
2016 176
2017 164
2018 154
2019 149
2020 167
2021 155
2022 153
2023 119
2024 28

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4,264 results

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Page 1
FADD at the Crossroads between Cancer and Inflammation.
Mouasni S, Tourneur L. Mouasni S, et al. Trends Immunol. 2018 Dec;39(12):1036-1053. doi: 10.1016/j.it.2018.10.005. Epub 2018 Nov 3. Trends Immunol. 2018. PMID: 30401514 Review.
Given the role of these signaling complexes, FADD has emerged as a new actor in innate immunity, inflammation, and cancer development. Concomitant to these new roles, a surprising number of mechanisms deemed to regulate FADD functions have been identified, including …
Given the role of these signaling complexes, FADD has emerged as a new actor in innate immunity, inflammation, and cancer development …
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
Rodriguez DA, Quarato G, Liedmann S, Tummers B, Zhang T, Guy C, Crawford JC, Palacios G, Pelletier S, Kalkavan H, Shaw JJP, Fitzgerald P, Chen MJ, Balachandran S, Green DR. Rodriguez DA, et al. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2207240119. doi: 10.1073/pnas.2207240119. Epub 2022 Oct 3. Proc Natl Acad Sci U S A. 2022. PMID: 36191211 Free PMC article.
Studies in vitro revealed an increased expression of ZBP1 in cells lacking FADD or Caspase-8, which was suppressed by reconstitution of Caspase-8 or FADD. ...Our study identifies a molecular mechanism whereby Caspase-8 and FADD suppress spontaneous necroptoti …
Studies in vitro revealed an increased expression of ZBP1 in cells lacking FADD or Caspase-8, which was suppressed by reconstitution …
FADD as a key molecular player in cancer progression.
Liu Y, Li X, Zhou X, Wang J, Ao X. Liu Y, et al. Mol Med. 2022 Nov 8;28(1):132. doi: 10.1186/s10020-022-00560-y. Mol Med. 2022. PMID: 36348274 Free PMC article. Review.
FADD dysregulation has been shown to be closely associated with the pathogenesis of numerous types of cancer. ...The information reviewed herein may expand researchers' understanding of FADD and contribute to the development of FADD-based therapeutic strategi
FADD dysregulation has been shown to be closely associated with the pathogenesis of numerous types of cancer. ...The information revi
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M. Schwarzer R, et al. Immunity. 2020 Jun 16;52(6):978-993.e6. doi: 10.1016/j.immuni.2020.04.002. Epub 2020 May 1. Immunity. 2020. PMID: 32362323 Free article.
Mice with IEC-specific FADD or caspase-8 deficiency developed colitis dependent on mixed lineage kinase-like (MLKL)-mediated epithelial cell necroptosis. However, MLKL deficiency fully prevented ileitis caused by epithelial caspase-8 ablation, but only partially ameliorate …
Mice with IEC-specific FADD or caspase-8 deficiency developed colitis dependent on mixed lineage kinase-like (MLKL)-mediated epitheli …
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Tummers B, Mari L, Guy CS, Heckmann BL, Rodriguez DA, Rühl S, Moretti J, Crawford JC, Fitzgerald P, Kanneganti TD, Janke LJ, Pelletier S, Blander JM, Green DR. Tummers B, et al. Immunity. 2020 Jun 16;52(6):994-1006.e8. doi: 10.1016/j.immuni.2020.04.010. Epub 2020 May 18. Immunity. 2020. PMID: 32428502 Free PMC article.
Removing both Fadd alleles from these mice resulted in early lethality prior to post-natal day 15 (P15), which was prevented by co-ablation of either Ripk1 or Caspase-1. Our results suggest an in vivo role of the inflammatory RIPK1-caspase-8-FADD (FADDosome) complex …
Removing both Fadd alleles from these mice resulted in early lethality prior to post-natal day 15 (P15), which was prevented by co-ab …
FADD and its phosphorylation.
Zhang J, Zhang D, Hua Z. Zhang J, et al. IUBMB Life. 2004 Jul;56(7):395-401. doi: 10.1080/15216540400008929. IUBMB Life. 2004. PMID: 15545216 Free article. Review.
Surprisingly, FADD is also involved in regulating T and B cell development. Accumulating evidences now suggest that FADD and its phosphorylation have additional roles in controlling pathways of cellular activation and proliferation, while the kinase modifying FAD
Surprisingly, FADD is also involved in regulating T and B cell development. Accumulating evidences now suggest that FADD and i …
FADD in Cancer: Mechanisms of Altered Expression and Function, and Clinical Implications.
Marín-Rubio JL, Vela-Martín L, Fernández-Piqueras J, Villa-Morales M. Marín-Rubio JL, et al. Cancers (Basel). 2019 Sep 29;11(10):1462. doi: 10.3390/cancers11101462. Cancers (Basel). 2019. PMID: 31569512 Free PMC article. Review.
Posttranslational modifications also constitute a relevant mechanism controlling FADD levels and functions in tumor cells. In this review, we aim to provide detailed, updated information on alterations leading to changes in FADD expression and function in cancer. Th …
Posttranslational modifications also constitute a relevant mechanism controlling FADD levels and functions in tumor cells. In this re …
FADD: a regulator of life and death.
Tourneur L, Chiocchia G. Tourneur L, et al. Trends Immunol. 2010 Jul;31(7):260-9. doi: 10.1016/j.it.2010.05.005. Epub 2010 Jun 25. Trends Immunol. 2010. PMID: 20576468 Review.
Recently, many of these new functions of FADD were shown to be independent of DRs. Moreover, FADD function is dictated by protein localization and phosphorylation state. Thus, FADD is a crucial and unique controller of many essential cellular processes. ...
Recently, many of these new functions of FADD were shown to be independent of DRs. Moreover, FADD function is dictated by prot …
The roles of FADD in extrinsic apoptosis and necroptosis.
Lee EW, Seo J, Jeong M, Lee S, Song J. Lee EW, et al. BMB Rep. 2012 Sep;45(9):496-508. doi: 10.5483/bmbrep.2012.45.9.186. BMB Rep. 2012. PMID: 23010170 Free article. Review.
Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negative FADD transgenic mice result in embryonic lethality and an immune defect without showing apoptotic features. Numerous studies hav …
Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-nega …
FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition.
Lin Y, Cai F, Wang X, Yang Y, Ren Y, Yao C, Yin X, Zhuang H, Hua Z. Lin Y, et al. Cell Cycle. 2023 Mar;22(5):580-595. doi: 10.1080/15384101.2022.2136463. Epub 2022 Oct 24. Cell Cycle. 2023. PMID: 36281535 Free PMC article.
Here, we report that FADD may play a critical role in the development of renal fibrosis. ...Further studies indicated that the TGF-beta1 pathway was also activated and the process of EMT was accelerated in both FADD-disrupted HEK293 cells and FADD-deficient M …
Here, we report that FADD may play a critical role in the development of renal fibrosis. ...Further studies indicated that the TGF-be …
4,264 results