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Year Number of Results
2008 2
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26 results

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Page 1
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.
Cho S, Chun Y, He L, Ramirez CB, Ganesh KS, Jeong K, Song J, Cheong JG, Li Z, Choi J, Kim J, Koundouros N, Ding F, Dephoure N, Jang C, Blenis J, Lee G. Cho S, et al. Mol Cell. 2023 Aug 17;83(16):3010-3026.e8. doi: 10.1016/j.molcel.2023.07.017. Mol Cell. 2023. PMID: 37595559
The mTORC1-activated SRPK2 phosphorylates splicing factor serine/arginine-rich splicing factor 1 (SRSF1), enhancing its binding to FAM120A. FAM120A directly interacts with a lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transc …
The mTORC1-activated SRPK2 phosphorylates splicing factor serine/arginine-rich splicing factor 1 (SRSF1), enhancing its binding to FAM120
Screening for functional circular RNAs using the CRISPR-Cas13 system.
Li S, Li X, Xue W, Zhang L, Yang LZ, Cao SM, Lei YN, Liu CX, Guo SK, Shan L, Wu M, Tao X, Zhang JL, Gao X, Zhang J, Wei J, Li J, Yang L, Chen LL. Li S, et al. Nat Methods. 2021 Jan;18(1):51-59. doi: 10.1038/s41592-020-01011-4. Epub 2020 Dec 7. Nat Methods. 2021. PMID: 33288960
Using a lentiviral library that targets sequences across BSJ sites of highly expressed human circRNAs, we show that a group of circRNAs are important for cell growth mostly in a cell-type-specific manner and that a common oncogenic circRNA, circFAM120A, promotes cell proliferatio …
Using a lentiviral library that targets sequences across BSJ sites of highly expressed human circRNAs, we show that a group of circRNAs are …
FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis.
Niu L, Li Y, Huang G, Huang W, Fu J, Feng L. Niu L, et al. Commun Biol. 2024 Apr 2;7(1):399. doi: 10.1038/s42003-024-06097-6. Commun Biol. 2024. PMID: 38565940 Free PMC article.
Mechanically, METTL3-induced m6A modification and YTHDC1-induced stability of FAM120A mRNA enhance FAM120A expression. FAM120A inhibits ferroptosis by binding SLC7A11 mRNA and enhancing its stability. ...These results reveal the function of FAM120A in …
Mechanically, METTL3-induced m6A modification and YTHDC1-induced stability of FAM120A mRNA enhance FAM120A expression. FAM1
Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis.
Ma J, Meng Q, Zhan J, Wang H, Fan W, Wang Y, Zhang S, Bian H, Zheng F. Ma J, et al. Inflammation. 2021 Dec;44(6):2309-2322. doi: 10.1007/s10753-021-01504-0. Epub 2021 Aug 23. Inflammation. 2021. PMID: 34423389
Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast-like synoviocytes (RA-FLSs). Circ-FAM120A was boosted in RA synovial tissues and RA-FLSs. Circ-FAM120A upregulation, miR-671-5p knockdown, …
Paeoniflorin restrained proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast-like synovio …
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
Eijsbouts C, Zheng T, Kennedy NA, Bonfiglio F, Anderson CA, Moutsianas L, Holliday J, Shi J, Shringarpure S; 23andMe Research Team; Voda AI; Bellygenes Initiative; Farrugia G, Franke A, Hübenthal M, Abecasis G, Zawistowski M, Skogholt AH, Ness-Jensen E, Hveem K, Esko T, Teder-Laving M, Zhernakova A, Camilleri M, Boeckxstaens G, Whorwell PJ, Spiller R, McVean G, D'Amato M, Jostins L, Parkes M. Eijsbouts C, et al. Nat Genet. 2021 Nov;53(11):1543-1552. doi: 10.1038/s41588-021-00950-8. Epub 2021 Nov 5. Nat Genet. 2021. PMID: 34741163 Free PMC article.
Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. ...
Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOC …
Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A.
Kelly TJ, Suzuki HI, Zamudio JR, Suzuki M, Sharp PA. Kelly TJ, et al. RNA. 2019 Oct;25(10):1291-1297. doi: 10.1261/rna.071621.119. Epub 2019 Jul 9. RNA. 2019. PMID: 31289130 Free PMC article.
Comparison of FAM120A iCLIP and Ago2 iCLIP reveals that greater than one-third of mRNAs bound by Ago2 in mESCs are co-bound by FAM120A. ...Reporter assays suggest that the 3'-UTRs of several FAM120A-bound miRNA target genes are less sensitive to Ago2-mediated …
Comparison of FAM120A iCLIP and Ago2 iCLIP reveals that greater than one-third of mRNAs bound by Ago2 in mESCs are co-bound by FAM
IL13 Receptor alpha2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis.
Bartolomé RA, García-Palmero I, Torres S, López-Lucendo M, Balyasnikova IV, Casal JI. Bartolomé RA, et al. Cancer Res. 2015 Jun 15;75(12):2434-44. doi: 10.1158/0008-5472.CAN-14-3650. Epub 2015 Apr 20. Cancer Res. 2015. PMID: 25896327 Free article.
In addition, FAM120A associated with kinesins and motor proteins involved in cargo movement along microtubules. ...FAM120A silencing abolished IL13-induced cell migration, invasion, and survival. ...
In addition, FAM120A associated with kinesins and motor proteins involved in cargo movement along microtubules. ...FAM120A sil …
Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations.
Chen WC, Brandenburg JT, Choudhury A, Hayat M, Sengupta D, Swiel Y, Babb de Villiers C, Ferndale L, Aldous C, Soo CC, Lee S, Curtis C, Newton R, Waterboer T, Sitas F, Bradshaw D, Abnet CC, Ramsay M, Parker MI, Singh E, Lewis CM, Mathew CG. Chen WC, et al. Am J Hum Genet. 2023 Oct 5;110(10):1690-1703. doi: 10.1016/j.ajhg.2023.08.007. Epub 2023 Sep 5. Am J Hum Genet. 2023. PMID: 37673066 Free PMC article.
We identified a genome-wide-significant risk locus on chromosome 9 upstream of FAM120A (rs12379660, p = 4.58 10(-8), odds ratio = 1.28, 95% confidence interval = 1.22-1.34), as well as a potential African-specific risk locus on chromosome 2 (rs142741123, p = 5.49 10(-8)) w …
We identified a genome-wide-significant risk locus on chromosome 9 upstream of FAM120A (rs12379660, p = 4.58 10(-8), odds ratio = 1.2 …
Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.
Mei H, Yin B, Yang W, Zhang J, Lu H, Qi X, Mei W, Zhang H, Zhang J. Mei H, et al. Biomed Res Int. 2022 Mar 7;2022:1499454. doi: 10.1155/2022/1499454. eCollection 2022. Biomed Res Int. 2022. PMID: 35295960 Free PMC article.
OBJECTIVES: To investigate risks of OW/OB associated with genetic variances in SEC16B rs543874 and rs10913469, BDNF rs11030104 and rs6265, NT5C2 rs11191580, PTBP2 rs11165675, ADCY9 rs2531995, FAM120A rs7869969, KCNQ1 rs2237892, and C4orf33 rs2968990 in Chinese infants at 1 …
OBJECTIVES: To investigate risks of OW/OB associated with genetic variances in SEC16B rs543874 and rs10913469, BDNF rs11030104 and rs6265, N …
Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.
Van Acker ZP, Van Raemdonck GA, Logie E, Van Acker SI, Baggerman G, Vanden Berghe W, Ponsaerts P, Dewilde S. Van Acker ZP, et al. Cells. 2019 Aug 11;8(8):873. doi: 10.3390/cells8080873. Cells. 2019. PMID: 31405213 Free PMC article.
., RPL15 and PCBP3) in an unstressed condition and shows an elevated binding ratio towards cell death-linked proteins, such as HNRNPA3, FAM120A, and ABRAXAS2, under ferroptotic stress. Our data also reveal a constitutive interaction between hNgb and the longevity-associate …
., RPL15 and PCBP3) in an unstressed condition and shows an elevated binding ratio towards cell death-linked proteins, such as HNRNPA3, F
26 results