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FAM135B sustains the reservoir of Tip60-ATM assembly to promote DNA damage response.
Zhang K, Wu Q, Liu W, Wang Y, Zhao L, Chen J, Liu H, Liu S, Li J, Zhang W, Zhan Q. Zhang K, et al. Clin Transl Med. 2022 Aug;12(8):e945. doi: 10.1002/ctm2.945. Clin Transl Med. 2022. PMID: 35979619 Free PMC article.
RESULTS: We identified a novel DDR regulator FAM135B which could protect cancer cells from genotoxic stress in vitro and in vivo. The overexpression of FAM135B promoted the removal of gammaH2AX and 53BP1 foci, whereas the elimination of FAM135B attenuated the …
RESULTS: We identified a novel DDR regulator FAM135B which could protect cancer cells from genotoxic stress in vitro and in vivo. The …
Silencing FAM135B enhances radiosensitivity of esophageal carcinoma cell.
Bi L, Wang H, Tian Y. Bi L, et al. Gene. 2021 Mar 10;772:145358. doi: 10.1016/j.gene.2020.145358. Epub 2020 Dec 17. Gene. 2021. PMID: 33340561
FAM135B (family with sequence similarity 135, member B) is related to the progression of esophageal squamous cell carcinoma (ESCC). ...Herein, we examined the relationship between FAM135B and radiosensitivity. According to the results, FAM135B is highly expre …
FAM135B (family with sequence similarity 135, member B) is related to the progression of esophageal squamous cell carcinoma (ESCC). . …
Aberrant FAM135B attenuates the efficacy of chemotherapy in colorectal cancer by modulating SRSF1-mediated alternative splicing.
Lin W, Xu L, Li Y, Li J, Zhao L. Lin W, et al. Oncogene. 2024 Nov;43(48):3532-3544. doi: 10.1038/s41388-024-03189-9. Epub 2024 Oct 13. Oncogene. 2024. PMID: 39397154
These findings reveal that the FAM135B-SRSF1 axis-mediated splicing contributes to DNA repair and chemotherapeutic insensitivity in CRC. Targeting FAM135B represents a potential strategy for CRC treatment....
These findings reveal that the FAM135B-SRSF1 axis-mediated splicing contributes to DNA repair and chemotherapeutic insensitivity in C …
METTL3-mediated upregulation of FAM135B promotes EMT of esophageal squamous cell carcinoma via regulating the Wnt/beta-catenin pathway.
Zhang TT, Yi W, Dong DZ, Ren ZY, Zhang Y, Du F. Zhang TT, et al. Am J Physiol Cell Physiol. 2024 Aug 1;327(2):C329-C340. doi: 10.1152/ajpcell.00529.2023. Epub 2024 Jun 17. Am J Physiol Cell Physiol. 2024. PMID: 38881420
Furthermore, epithelial-mesenchymal transition (EMT)-related pathways were enriched in ESCC samples with high levels of FAM135B and FAM135B positively regulated EMT markers. Mechanistically, we observed that FAM135B interacted with the intermediate domain of …
Furthermore, epithelial-mesenchymal transition (EMT)-related pathways were enriched in ESCC samples with high levels of FAM135B and …
A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward Loop Promotes Esophageal Squamous Cell Carcinoma Progression.
Dong D, Zhang W, Xiao W, Wu Q, Cao Y, Gao X, Huang L, Wang Y, Chen J, Wang W, Zhan Q. Dong D, et al. Cancer Res. 2021 Feb 15;81(4):910-922. doi: 10.1158/0008-5472.CAN-20-0912. Epub 2020 Dec 15. Cancer Res. 2021. PMID: 33323378
In this study, we demonstrate that the protein levels of FAM135B are significantly higher in ESCC tissues than in precancerous tissues, and high expression of FAM135B correlates with poorer clinical prognosis. ...These findings suggest that the interaction between …
In this study, we demonstrate that the protein levels of FAM135B are significantly higher in ESCC tissues than in precancerous tissue …
Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy.
Foronda H, Fu Y, Covarrubias-Pinto A, Bocker HT, González A, Seemann E, Franzka P, Bock A, Bhaskara RM, Liebmann L, Hoffmann ME, Katona I, Koch N, Weis J, Kurth I, Gleeson JG, Reggiori F, Hummer G, Kessels MM, Qualmann B, Mari M, Dikić I, Hübner CA. Foronda H, et al. Nature. 2023 Jun;618(7964):402-410. doi: 10.1038/s41586-023-06090-9. Epub 2023 May 24. Nature. 2023. PMID: 37225994 Free PMC article.
Identification of genomic alterations in oesophageal squamous cell cancer.
Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q. Song Y, et al. Nature. 2014 May 1;509(7498):91-5. doi: 10.1038/nature13176. Epub 2014 Mar 16. Nature. 2014. PMID: 24670651
We identified eight significantly mutated genes, of which six are well known tumour-associated genes (TP53, RB1, CDKN2A, PIK3CA, NOTCH1, NFE2L2), and two have not previously been described in ESCC (ADAM29 and FAM135B). Notably, FAM135B is identified as a novel cance …
We identified eight significantly mutated genes, of which six are well known tumour-associated genes (TP53, RB1, CDKN2A, PIK3CA, NOTCH1, NFE …
Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance.
Wang T, Lv X, Jiang S, Han S, Wang Y. Wang T, et al. Oncol Lett. 2020 Mar;19(3):1727-1734. doi: 10.3892/ol.2020.11272. Epub 2020 Jan 9. Oncol Lett. 2020. PMID: 32194665 Free PMC article.
However, to the best of our knowledge, the expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelial cells to ESCC has not yet been investigated. The present study aimed to investigate the expression of ADAM29 and FAM135B in no …
However, to the best of our knowledge, the expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epit …
[Expression pattern of FAM135B and K (lysine) acetyltransferase 5 in esophageal squamous cell carcinoma in Uygur patients].
Liu J, Zhu JL, Zhang YL, Bai Y. Liu J, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2018 Feb 20;38(2):224-228. doi: 10.3969/j.issn.1673-4254.2018.02.17. Nan Fang Yi Ke Da Xue Xue Bao. 2018. PMID: 29502064 Free PMC article. Chinese.
The correlation of FAM135B and KAT5 and their correlation with the clinicopathological characteristics of the patients were analyzed. RESULTS: The positivity rates of FAM135B and KAT5 in ESCC tissues were 92.50% (37/40) and 15.00%(6/40) in these patients, respective …
The correlation of FAM135B and KAT5 and their correlation with the clinicopathological characteristics of the patients were analyzed. …
30 results