Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1998 1
2001 1
2002 1
2003 3
2004 5
2005 8
2006 13
2007 21
2008 45
2009 55
2010 70
2011 85
2012 138
2013 155
2014 156
2015 168
2016 191
2017 209
2018 216
2019 280
2020 310
2021 343
2022 365
2023 372
2024 407
2025 550
2026 141

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

3,794 results

Results by year

Filters applied: . Clear all
Page 1
FBXW7beta loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth.
Wei W, Qin B, Wen W, Zhang B, Luo H, Wang Y, Xu H, Xie X, Liu S, Jiang X, Wang M, Tang Q, Zhang J, Yang R, Fan Z, Lyu H, Lin J, Li K, Lee MH. Wei W, et al. Signal Transduct Target Ther. 2023 May 19;8(1):187. doi: 10.1038/s41392-023-01405-8. Signal Transduct Target Ther. 2023. PMID: 37202390 Free PMC article.
Here, we report that FBXW7beta, a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC, is an E3 ligase of fatty acid synthase (FASN). Cancer-specific FBXW7beta mutations that could not degrade FASN can lead to sustained lipogenesis in CRC. ...Both C …
Here, we report that FBXW7beta, a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC, is an E3 ligase of fatty acid syntha …
FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma.
Huang J, Tsang WY, Fang XN, Zhang Y, Luo J, Gong LQ, Zhang BF, Wong CN, Li ZH, Liu BL, Huang JL, Yang YM, Liu S, Ban LX, Chan YH, Guan XY. Huang J, et al. Cancer Res. 2024 Mar 15;84(6):855-871. doi: 10.1158/0008-5472.CAN-23-0966. Cancer Res. 2024. PMID: 38486485
Mechanistically, FASN inhibition reduced palmitoylation of MHC-I that led to its lysosomal degradation. ...Multiplex IHC of human HCC samples and bioinformatic analysis of The Cancer Genome Atlas data further illustrated that lower expression of FASN was correlated …
Mechanistically, FASN inhibition reduced palmitoylation of MHC-I that led to its lysosomal degradation. ...Multiplex IHC of human HCC …
FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma.
Xu L, Zhang Y, Lin Z, Deng X, Ren X, Huang M, Li S, Zhou Q, Fang F, Yang Q, Zheng G, Chen Z, Wu Z, Sun X, Lin J, Shen J, Guo J, Li X, Xue T, Tan J, Lin X, Tan L, Peng H, Shen S, Peng S, Li S, Liang L, Cleary JM, Lai J, Xie Y, Kuang M. Xu L, et al. J Hepatol. 2024 Aug;81(2):265-277. doi: 10.1016/j.jhep.2024.03.016. Epub 2024 Mar 19. J Hepatol. 2024. PMID: 38508240
Fatty acid biosynthesis and the expression of fatty acid synthase (FASN), a key enzyme catalyzing long-chain fatty acid synthesis, were significantly enriched in C. sinensis-related iCCAs. iCCA cell lines treated with excretory/secretory products of C. sinensis displayed e …
Fatty acid biosynthesis and the expression of fatty acid synthase (FASN), a key enzyme catalyzing long-chain fatty acid synthesis, we …
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Du Q, Liu P, Zhang C, Liu T, Wang W, Shang C, Wu J, Liao Y, Chen Y, Huang J, Tan H, Zhao Y, Xia M, Liu J, Yao S. Du Q, et al. Cell Death Dis. 2022 May 21;13(5):488. doi: 10.1038/s41419-022-04926-2. Cell Death Dis. 2022. PMID: 35597782 Free PMC article.
Moreover, multivariate Cox proportional hazards analysis identified FASN as an independent prognostic factor of CC patients. Furthermore, gain-of-function and loss-of-function approaches showed that FASN promoted CC cell migration, invasion, and lymphangiogenesis. . …
Moreover, multivariate Cox proportional hazards analysis identified FASN as an independent prognostic factor of CC patients. Furtherm …
FASN regulates STING palmitoylation via malonyl-CoA in macrophages to alleviate sepsis-induced liver injury.
Kang J, Wu J, Liu Q, Jiang H, Li W, Li Y, Li X, Ni C, Wu L, Liu M, Liu H, Deng L, Lin Z, Wu X, Zhao Y, Ren J. Kang J, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167299. doi: 10.1016/j.bbadis.2024.167299. Epub 2024 Jun 13. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38878833 Free article.
The compounds library was screened, revealing that FASN inhibitors exerted a significant inhibitory effect on the STING pathway. Mechanically, the regulatory effect of FASN on the STING pathway was dependent on palmitoylation. Further experiments indicated that the …
The compounds library was screened, revealing that FASN inhibitors exerted a significant inhibitory effect on the STING pathway. Mech …
Targeting ZDHHC21/FASN axis for the treatment of diffuse large B-cell lymphoma.
Liu B, Zhao X, Zhang S, Li Q, Li X, Huang D, Xia J, Ma N, Duan Y, Zhang X, Rao J. Liu B, et al. Leukemia. 2024 Feb;38(2):351-364. doi: 10.1038/s41375-023-02130-5. Epub 2024 Jan 9. Leukemia. 2024. PMID: 38195819 Free PMC article.
Mechanistically, ZDHHC21 interacted with FASN and mediated its palmitoylation at Cys1317, resulting in a decrease in FASN protein stability and fatty acid synthesis, consequently leading to the inhibition of DLBCL cell growth. ...Our results demonstrate that ZDHHC21 …
Mechanistically, ZDHHC21 interacted with FASN and mediated its palmitoylation at Cys1317, resulting in a decrease in FASN prot …
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Gu L, Zhu Y, Lin X, Tan X, Lu B, Li Y. Gu L, et al. Oncogene. 2020 Mar;39(11):2437-2449. doi: 10.1038/s41388-020-1156-0. Epub 2020 Jan 23. Oncogene. 2020. PMID: 31974474
Conversely, GNPAT deacetylation by SIRT4 antagonizes ACAT1's function. GNPAT represses TRIM21-mediated FASN degradation and promotes lipid metabolism. Furthermore, shRNA-mediated ACAT1 ablation and acetylation deficiency of GNPAT repress lipid metabolism and tumor progress …
Conversely, GNPAT deacetylation by SIRT4 antagonizes ACAT1's function. GNPAT represses TRIM21-mediated FASN degradation and promotes …
Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation.
Liu J, Shen Y, Liu J, Xu D, Chang CY, Wang J, Zhou J, Haffty BG, Zhang L, Bargonetti J, De S, Hu W, Feng Z. Liu J, et al. Nat Commun. 2025 Feb 19;16(1):1762. doi: 10.1038/s41467-025-57099-9. Nat Commun. 2025. PMID: 39971971 Free PMC article.
Currently, the mechanism of mutp53 accumulation and GOF is incompletely understood. Here, we identify the lipogenic enzyme FASN as an important regulator of mutp53 accumulation and GOF. FASN interacts with mutp53 to enhance mutp53 palmitoylation, which inhibits mutp …
Currently, the mechanism of mutp53 accumulation and GOF is incompletely understood. Here, we identify the lipogenic enzyme FASN as an …
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
Qian Z, Jiang Y, Cai Y, Gao E, Wang C, Dong J, Wang F, Liu L, Wu D, Zhang F, Wang Y, Ning X, Li Q, You Y, Gu Y, Mei J, Zhao X, Zhang Y. Qian Z, et al. J Exp Clin Cancer Res. 2025 Oct 14;44(1):289. doi: 10.1186/s13046-025-03548-8. J Exp Clin Cancer Res. 2025. PMID: 41088402 Free PMC article.
While the close association between fatty acid metabolism and ferroptosis has been studied in various diseases, the interplay between the key fatty acid metabolic enzyme fatty acid synthase (FASN) and ferroptosis in BC remains unexplored. At the beginning of the current st …
While the close association between fatty acid metabolism and ferroptosis has been studied in various diseases, the interplay between the ke …
FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression.
Ye M, Hu C, Chen T, Yu P, Chen J, Lu F, Xu L, Zhong Y, Yan L, Kan J, Bai J, Li X, Tian Y, Tang Q. Ye M, et al. Int J Biol Sci. 2023 Jun 12;19(10):3115-3127. doi: 10.7150/ijbs.85285. eCollection 2023. Int J Biol Sci. 2023. PMID: 37416772 Free PMC article.
In terms of mechanistic insights, FABP5 interacted with fatty acid synthase (FASN) and activated the ubiquitin proteasome pathway, leading to a decrease in FASN expression and lipid accumulation, moreover, suppressing mTOR signaling and facilitating cell autophagy. …
In terms of mechanistic insights, FABP5 interacted with fatty acid synthase (FASN) and activated the ubiquitin proteasome pathway, le …
3,794 results