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Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5.
Terzi EM, Sviderskiy VO, Alvarez SW, Whiten GC, Possemato R. Terzi EM, et al. Sci Adv. 2021 May 26;7(22):eabg4302. doi: 10.1126/sciadv.abg4302. Print 2021 May. Sci Adv. 2021. PMID: 34039609 Free PMC article.
However, IRP2 is principally thought to be regulated at the protein level via E3 ubiquitin ligase FBXL5-mediated degradation. Here, we show that ISC synthesis suppression can activate IRP2 and promote ferroptosis sensitivity via a previously unidentified mechanism. At tiss …
However, IRP2 is principally thought to be regulated at the protein level via E3 ubiquitin ligase FBXL5-mediated degradation. Here, w …
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
Wang H, Shi H, Rajan M, Canarie ER, Hong S, Simoneschi D, Pagano M, Bush MF, Stoll S, Leibold EA, Zheng N. Wang H, et al. Mol Cell. 2020 Apr 2;78(1):31-41.e5. doi: 10.1016/j.molcel.2020.02.011. Epub 2020 Mar 2. Mol Cell. 2020. PMID: 32126207 Free PMC article.
However, how the physical interaction between FBXL5 and IRP2 is regulated remains elusive. Here, we show that the C-terminal substrate-binding domain of FBXL5 harbors a [2Fe2S] cluster in the oxidized state. A cryoelectron microscopy (cryo-EM) structure of the IRP2- …
However, how the physical interaction between FBXL5 and IRP2 is regulated remains elusive. Here, we show that the C-terminal substrat …
Circular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a.
Li D, You J, Mao C, Zhou E, Han Z, Zhang J, Zhang T, Wang C. Li D, et al. J Inflamm Res. 2022 Apr 21;15:2539-2550. doi: 10.2147/JIR.S360129. eCollection 2022. J Inflamm Res. 2022. PMID: 35479829 Free PMC article.
Knockdown of circRNA Fbxl5 ameliorated cardiomyocyte apoptosis, thereby decreasing infarct size and preserving cardiac function. Additionally, in vitro knockdown of circRNA Fbxl5 in NMVMs subjected to AR recapitulated the in vivo findings. ...
Knockdown of circRNA Fbxl5 ameliorated cardiomyocyte apoptosis, thereby decreasing infarct size and preserving cardiac function. Addi …
Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase.
Iwai K. Iwai K. Free Radic Biol Med. 2019 Mar;133:64-68. doi: 10.1016/j.freeradbiomed.2018.09.011. Epub 2018 Sep 13. Free Radic Biol Med. 2019. PMID: 30218771 Review.
It is also well-known that the ubiquitin system plays central roles in cellular iron regulation because both IRPs having the IRE binding activity are recognized and ubiquitinated by the SCF(FBXL5) ubiquitin ligase in condition of iron-replete. FBXL5, which is a subs …
It is also well-known that the ubiquitin system plays central roles in cellular iron regulation because both IRPs having the IRE binding act …
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI. Muto Y, et al. J Exp Med. 2019 Apr 1;216(4):950-965. doi: 10.1084/jem.20180900. Epub 2019 Mar 15. J Exp Med. 2019. PMID: 30877170 Free PMC article.
The tumor-promoting outcome of FBXL5 deficiency in the liver was also found to be effective in a model of virus-induced HCC. ...In addition, dysregulation of FBXL5-mediated cellular iron homeostasis was found to be associated with poor prognosis in human HCC, sugges …
The tumor-promoting outcome of FBXL5 deficiency in the liver was also found to be effective in a model of virus-induced HCC. ...In ad …
F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.
Ruiz JC, Bruick RK. Ruiz JC, et al. J Inorg Biochem. 2014 Apr;133:73-7. doi: 10.1016/j.jinorgbio.2014.01.015. Epub 2014 Jan 25. J Inorg Biochem. 2014. PMID: 24508277 Free PMC article. Review.
In addition, the FBXL5-Hr domain also senses O2 availability, albeit by a distinct mechanism. ...Here, we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS biology....
In addition, the FBXL5-Hr domain also senses O2 availability, albeit by a distinct mechanism. ...Here, we describe the iron and oxyge …
Ferroportin and FBXL5 as Prognostic Markers in Advanced Stage Clear Cell Renal Cell Carcinoma.
Park CK, Heo J, Ham WS, Choi YD, Shin SJ, Cho NH. Park CK, et al. Cancer Res Treat. 2021 Oct;53(4):1174-1183. doi: 10.4143/crt.2021.031. Epub 2021 Mar 17. Cancer Res Treat. 2021. PMID: 33735560 Free PMC article.
RESULTS: FPN and FBXL5 immunohistochemistry showed membrane and cytoplasmic expression, respectively. Based on the H-score, cases were classified as low or high expression with a cutoff value of 20 for FPN and 15 for FBXL5, respectively. Low expression of FPN and …
RESULTS: FPN and FBXL5 immunohistochemistry showed membrane and cytoplasmic expression, respectively. Based on the H-score, cases wer …
FBXL5 attenuates RhoGDI2-induced cisplatin resistance in gastric cancer cells.
Wu WD, Wang M, Ding HH, Qiu ZJ. Wu WD, et al. Eur Rev Med Pharmacol Sci. 2016 Jun;20(12):2551-7. Eur Rev Med Pharmacol Sci. 2016. PMID: 27383304 Free article.
RESULTS: Depletion of FBXL5 enhances cisplatin resistance of gastric cancer cells through Erk and p38 activation. However, FBXL5 did not affect the abundance and stability of RhoGDI2. Instead, FBXL5 was rapidly degraded in response to cisplatin treatment in R …
RESULTS: Depletion of FBXL5 enhances cisplatin resistance of gastric cancer cells through Erk and p38 activation. However, FBXL5 …
FBXL5 inhibits metastasis of gastric cancer through suppressing Snail1.
Wu W, Ding H, Cao J, Zhang W. Wu W, et al. Cell Physiol Biochem. 2015;35(5):1764-72. doi: 10.1159/000373988. Epub 2015 Mar 26. Cell Physiol Biochem. 2015. PMID: 25832584 Free article.
Co-immunoprecipitation (IP) was performed to detect the interaction between Snail1 and FBXL5 in GC cells. The effects on Snail1 by FBXL5 were examined by overexpression of depletion of FBXL5 in GC cells. ...RESULTS: FBXL5 also physiologically interacte …
Co-immunoprecipitation (IP) was performed to detect the interaction between Snail1 and FBXL5 in GC cells. The effects on Snail1 by …
FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI. Yamauchi T, et al. Mol Cell Biol. 2017 Mar 31;37(8):e00470-16. doi: 10.1128/MCB.00470-16. Print 2017 Apr 15. Mol Cell Biol. 2017. PMID: 28069738 Free PMC article.
This early embryonic mortality has thus impeded study of the role of FBXL5 in brain development. We have now generated mice lacking FBXL5 specifically in nestin-expressing neural stem progenitor cells (NSPCs) in the brain. ...Our results thus show that FBXL5 …
This early embryonic mortality has thus impeded study of the role of FBXL5 in brain development. We have now generated mice lacking …
75 results