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PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors.
Ferdosi SR, Taylor B, Lee M, Tang N, Peng S, Bybee R, Reid G, Hartman L, Garcia-Mansfield K, Sharma R, Pirrotte P, Ma J, Parisian AD, Furnari F, Dhruv HD, Berens ME. Ferdosi SR, et al. Neuro Oncol. 2022 Nov 2;24(11):1857-1868. doi: 10.1093/neuonc/noac067. Neuro Oncol. 2022. Retraction in: Neuro Oncol. 2024 Apr 5;26(4):775. doi: 10.1093/neuonc/noad081 PMID: 35305088 Free PMC article. Retracted.