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The Microbiome and Aging.
Bana B, Cabreiro F. Bana B, et al. Among authors: cabreiro f. Annu Rev Genet. 2019 Dec 3;53:239-261. doi: 10.1146/annurev-genet-112618-043650. Epub 2019 Sep 5. Annu Rev Genet. 2019. PMID: 31487470 Review.
Aging is a natural process of organismal decay that underpins the development of myriad diseases and disorders. ...Importantly, we propose microbiome dysbiosis as an additional hallmark and biomarker of aging....
Aging is a natural process of organismal decay that underpins the development of myriad diseases and disorders. ...Importantly, we pr
C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals.
Franco-Romero A, Morbidoni V, Milan G, Sartori R, Wulff J, Romanello V, Armani A, Salviati L, Conte M, Salvioli S, Franceschi C, Buonomo V, Swoboda CO, Grumati P, Pannone L, Martinelli S, Jefferies HB, Dikic I, van der Laan J, Cabreiro F, Millay DP, Tooze SA, Trevisson E, Sandri M. Franco-Romero A, et al. Among authors: cabreiro f. J Clin Invest. 2024 Jun 13;134(15):e165814. doi: 10.1172/JCI165814. J Clin Invest. 2024. PMID: 38869949 Free PMC article.
The identification of genes that confer either extension of life span or accelerate age-related decline was a step forward in understanding the mechanisms of aging and revealed that it is partially controlled by genetics and transcriptional programs. ...We conclude that MY …
The identification of genes that confer either extension of life span or accelerate age-related decline was a step forward in understanding …
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D. Cabreiro F, et al. Cell. 2013 Mar 28;153(1):228-39. doi: 10.1016/j.cell.2013.02.035. Cell. 2013. PMID: 23540700 Free PMC article.
This bacterium exerts complex nutritional and pathogenic effects on its nematode predator/host that impact health and aging. We report that metformin increases lifespan by altering microbial folate and methionine metabolism. ...
This bacterium exerts complex nutritional and pathogenic effects on its nematode predator/host that impact health and aging. We repor …
Enhancing autophagy by redox regulation extends lifespan in Drosophila.
Lennicke C, Bjedov I, Grönke S, Menger KE, James AM, Castillo-Quan JI, van Leeuwen LAG, Foley A, Buricova M, Adcott J, Montoya A, Kramer HB, Shliaha PV, Logan A, Cabreiro F, Murphy MP, Partridge L, Cochemé HM. Lennicke C, et al. Among authors: cabreiro f. Nat Commun. 2025 Jun 25;16(1):5379. doi: 10.1038/s41467-025-60603-w. Nat Commun. 2025. PMID: 40562835 Free PMC article.
Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H(2)O(2) in vivo, we established a redox-shifted model by manipulating levels of the H(2)O(2)-degrading enzyme catalase in Drosoph …
Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox sign …
Chemotherapy modulation by a cancer-associated microbiota metabolite.
Martinez-Martinez D, Peres TV, Gehling K, Quintaneiro L, Cabrera C, Cherevatenko M, Cutty SJ, Best L, Marinos G, Zimmerman J, Safoor A, Chrysostomou D, Mokochinski JB, Montoya A, Brodesser S, Zatorska M, Scott T, Andrew I, Kramer H, Begum M, Zhang B, Golding BT, Marchesi JR, Hirabayashi S, Kaleta C, Barr AR, Frezza C, Cochemé HM, Cabreiro F. Martinez-Martinez D, et al. Among authors: cabreiro f. Cell Syst. 2025 Sep 17;16(9):101397. doi: 10.1016/j.cels.2025.101397. Epub 2025 Sep 10. Cell Syst. 2025. PMID: 40934913 Free article.
ARDD 2020: from aging mechanisms to interventions.
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. Mkrtchyan GV, et al. Among authors: cabreiro f. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30. Aging (Albany NY). 2020. PMID: 33378272 Free PMC article. Review.
Aging is emerging as a druggable target with growing interest from academia, industry and investors. ...The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target
Aging is emerging as a druggable target with growing interest from academia, industry and investors. ...The meeting covered topics re
Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut.
Regina A, Solagna F, Estrada MS, Jacobs MME, Martinez-Martinez D, Georgomanolis T, Alibashikj I, Gjurgji S, Pearson C, Chang D, Moschandrea C, Aparisi AS, Crespo E, Buechel J, Schneider F, Trojahn L, Pfelzer P, Popovic M, Potenza E, Kabat AM, Niessen C, Amulic B, Safinia N, Cogliati S, Sanin DE, Villa M, Pearce EJ, Frezza C, Pearce EL, Cabreiro F, Powrie F, Corrado M. Regina A, et al. Among authors: cabreiro f. Nat Metab. 2026 Jun;8(6):1368-1389. doi: 10.1038/s42255-026-01533-9. Epub 2026 May 18. Nat Metab. 2026. PMID: 42151382 Free PMC article.
Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses.
Renz A, Hohner M, Jami R, Breitenbach M, Josephs-Spaulding J, Dürrwald J, Best L, Dulière V, Mialon C, Bader SM, Marinos G, Leonidou N, Cabreiro F, Pellegrini M, Doerflinger M, Rosa-Calatrava M, Pizzorno A, Dräger A, Schindler M, Kaleta C. Renz A, et al. Among authors: cabreiro f. Commun Biol. 2025 May 23;8(1):791. doi: 10.1038/s42003-025-08148-y. Commun Biol. 2025. PMID: 40410544 Free PMC article.
Increased fidelity of protein synthesis extends lifespan.
Martinez-Miguel VE, Lujan C, Espie-Caullet T, Martinez-Martinez D, Moore S, Backes C, Gonzalez S, Galimov ER, Brown AEX, Halic M, Tomita K, Rallis C, von der Haar T, Cabreiro F, Bjedov I. Martinez-Miguel VE, et al. Among authors: cabreiro f. Cell Metab. 2021 Nov 2;33(11):2288-2300.e12. doi: 10.1016/j.cmet.2021.08.017. Epub 2021 Sep 14. Cell Metab. 2021. PMID: 34525330 Free PMC article.
Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal aging is poorly understood. ...This impl …
Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiol …
31 results