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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2002 3
2003 2
2004 2
2005 4
2006 2
2007 7
2008 1
2009 3
2010 1
2011 5
2012 5
2013 7
2014 7
2015 13
2016 7
2017 11
2018 13
2019 13
2020 13
2021 3
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110 results
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Page 1
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Mackman RL, Mish M, Chin G, Perry JK, Appleby T, Aktoudianakis V, Metobo S, Pyun P, Niu C, Daffis S, Yu H, Zheng J, Villasenor AG, Zablocki J, Chamberlain J, Jin H, Lee G, Suekawa-Pirrone K, Santos R, Delaney WE 4th, Fletcher SP. Mackman RL, et al. Among authors: fletcher sp. J Med Chem. 2020 Sep 24;63(18):10188-10203. doi: 10.1021/acs.jmedchem.0c00100. Epub 2020 Jun 3. J Med Chem. 2020. PMID: 32407112
Therapeutic potential of TLR8 agonist GS-9688 (selgantolimod) in chronic hepatitis B: re-modelling of antiviral and regulatory mediators.
Amin OE, Colbeck EJ, Daffis S, Khan S, Ramakrishnan D, Pattabiraman D, Chu R, Micolochick Steuer H, Lehar S, Peiser L, Palazzo A, Frey C, Davies J, Javanbakht H, Rosenberg WMC, Fletcher SP, Maini MK, Pallett LJ. Amin OE, et al. Among authors: fletcher sp. Hepatology. 2020 Dec 25. doi: 10.1002/hep.31695. Online ahead of print. Hepatology. 2020. PMID: 33368377
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Daffis S, Balsitis S, Chamberlain J, Zheng J, Santos R, Rowe W, Ramakrishnan D, Pattabiraman D, Spurlock S, Chu R, Kang D, Mish M, Ramirez R, Li L, Li B, Ma S, Hung M, Voitenleitner C, Yon C, Suresh M, Menne S, Cote P, Delaney WE 4th, Mackman R, Fletcher SP. Daffis S, et al. Among authors: fletcher sp. Hepatology. 2021 Jan;73(1):53-67. doi: 10.1002/hep.31255. Epub 2020 Nov 27. Hepatology. 2021. PMID: 32246499 Free PMC article.
A chemically fuelled self-replicator.
Morrow SM, Colomer I, Fletcher SP. Morrow SM, et al. Among authors: fletcher sp. Nat Commun. 2019 Mar 1;10(1):1011. doi: 10.1038/s41467-019-08885-9. Nat Commun. 2019. PMID: 30824804 Free PMC article.
A molecular assembler that produces polymers.
Engwerda AHJ, Fletcher SP. Engwerda AHJ, et al. Among authors: fletcher sp. Nat Commun. 2020 Aug 19;11(1):4156. doi: 10.1038/s41467-020-17814-0. Nat Commun. 2020. PMID: 32814774 Free PMC article.
A transient self-assembling self-replicator.
Colomer I, Morrow SM, Fletcher SP. Colomer I, et al. Among authors: fletcher sp. Nat Commun. 2018 Jun 8;9(1):2239. doi: 10.1038/s41467-018-04670-2. Nat Commun. 2018. PMID: 29884880 Free PMC article.
110 results
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