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1991 1
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92 results

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Page 1
Filaggrinopathies-FLG/FLG2: Diagnostic Complexities and Immunotherapy.
Nouri Z, Biglari S, Tabatabaiefar MA, Vahidnezhad F, Hozhabrpour A, March ME, Margolis DJ, Gudjonsson JE, Hakonarson H, Vahidnezhad H. Nouri Z, et al. J Invest Dermatol. 2025 Jul;145(7):1622-1632. doi: 10.1016/j.jid.2024.12.008. Epub 2025 Feb 7. J Invest Dermatol. 2025. PMID: 39927906 Review.
FLG and FLG2 proteins are expressed in the outer layers of the epidermis, where they are vital in epidermal differentiation and skin barrier formation. ...This review examines biosynthesis and function of FLG and FLG2 proteins and evaluates their molecular pathogene …
FLG and FLG2 proteins are expressed in the outer layers of the epidermis, where they are vital in epidermal differentiation and skin …
Integrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for ARDS.
Lin M, Xu F, Sun J, Song J, Shen Y, Lu S, Ding H, Lan L, Chen C, Ma W, Wu X, Song Z, Wang W. Lin M, et al. Crit Care. 2024 Jul 2;28(1):213. doi: 10.1186/s13054-024-05000-3. Crit Care. 2024. PMID: 38956604 Free PMC article.
In the discovery cohort, a panel of 36 proteins was identified as candidate biomarkers, with 8 proteins (VCAM1, LDHB, MSN, FLG2, TAGLN2, LMNA, MBL2, and LBP) demonstrating significant consistency in an independent validation cohort of 183 patients (mean age 72.6 years, 73. …
In the discovery cohort, a panel of 36 proteins was identified as candidate biomarkers, with 8 proteins (VCAM1, LDHB, MSN, FLG2, TAGL …
Gene Expression Linked to Reepithelialization of Human Skin Wounds.
Ågren MS, Litman T, Eriksen JO, Schjerling P, Bzorek M, Gjerdrum LMR. Ågren MS, et al. Int J Mol Sci. 2022 Dec 12;23(24):15746. doi: 10.3390/ijms232415746. Int J Mol Sci. 2022. PMID: 36555389 Free PMC article.
The six downregulated DEGs (COL7A1, MMP28, SLC39A2, FLG1, KRT10 and FLG2) were associated with epidermal maturation. KLK8 showed the strongest correlation with MKI67 mRNA levels and is a potential biomarker for keratinocyte proliferation. ...
The six downregulated DEGs (COL7A1, MMP28, SLC39A2, FLG1, KRT10 and FLG2) were associated with epidermal maturation. KLK8 showed the …
Uncommon variants in FLG2 and TCHHL1 are associated with remission of atopic dermatitis in a large longitudinal US cohort.
Berna R, Mitra N, Hoffstad O, Wubbenhorst B, Nathanson KL, Margolis DJ. Berna R, et al. Arch Dermatol Res. 2022 Dec;314(10):953-959. doi: 10.1007/s00403-021-02319-7. Epub 2022 Jan 4. Arch Dermatol Res. 2022. PMID: 34984527 Free PMC article.
We sought to evaluate the association between variation in FLG2, TCHHL1 and AD remission. We sequenced FLG2 and TCHHL1 in a longitudinal AD cohort using targeted capture-based massively parallel sequencing. ...Our study supports the role of uncommon alleles in FL …
We sought to evaluate the association between variation in FLG2, TCHHL1 and AD remission. We sequenced FLG2 and TCHHL1 in a lo …
Uncommon Variants in FLG2 and NOD2 Are Associated with Atopic Dermatitis in the Ethiopian Population.
Wang S, Elmgren JK, Eisfeldt J, Asad S, Ek M, Bilcha K, Befekadu A, Wahlgren CF, Nordenskjöld M, Taylan F, Tapia-Paez I, Bradley M. Wang S, et al. JID Innov. 2024 Apr 29;4(4):100284. doi: 10.1016/j.xjidi.2024.100284. eCollection 2024 Jul. JID Innov. 2024. PMID: 38859976 Free PMC article.
We sought to investigate the genetic origins of AD by performing whole-genome sequencing in an Ethiopian family with 12 individuals and several affected in different generations. We identified 2 variants within FLG2 (p.D13Y) and NOD2 (p.A918S) genes cosegregating with AD i …
We sought to investigate the genetic origins of AD by performing whole-genome sequencing in an Ethiopian family with 12 individuals and seve …
Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis.
He H, Bissonnette R, Wu J, Diaz A, Saint-Cyr Proulx E, Maari C, Jack C, Louis M, Estrada Y, Krueger JG, Zhang N, Pavel AB, Guttman-Yassky E. He H, et al. J Allergy Clin Immunol. 2021 Jan;147(1):199-212. doi: 10.1016/j.jaci.2020.05.048. Epub 2020 Jul 21. J Allergy Clin Immunol. 2021. PMID: 32709423
AD and psoriasis tissues shared increases in levels of dendritic cell and T-cell markers (CD3, ITGAX/CD11c, and CD83), but AD tissues showed preferential T(H)2 skewing (IL-13, CCL17/TARC, and CCL18), whereas psoriasis was characterized by higher levels of expression of T(H)17-rel …
AD and psoriasis tissues shared increases in levels of dendritic cell and T-cell markers (CD3, ITGAX/CD11c, and CD83), but AD tissues showed …
Whole-exome sequencing indicates FLG2 variant associated with leg ulcers in Brazilian sickle cell anemia patients.
de Carvalho-Siqueira GQ, Ananina G, de Souza BB, Borges MG, Ito MT, da Silva-Costa SM, de Farias Domingos I, Falcão DA, Lopes-Cendes I, Bezerra MAC, da Silva Araújo A, Lucena-Araújo AR, de Souza Gonçalves M, Saad STO, Costa FF, de Melo MB. de Carvalho-Siqueira GQ, et al. Exp Biol Med (Maywood). 2019 Aug;244(11):932-939. doi: 10.1177/1535370219849592. Epub 2019 May 12. Exp Biol Med (Maywood). 2019. PMID: 31079484 Free PMC article.
After the validation, Fisher's exact test revealed a statistically significant difference in a stop codon variant (rs12568784 G/T) in the FLG2 gene between the GT and GG genotypes (P = 0.035). We highlight the importance of rs12568784 in leg ulcer development as this varia …
After the validation, Fisher's exact test revealed a statistically significant difference in a stop codon variant (rs12568784 G/T) in the …
92 results