Allosteric modulation of α1β3γ2 GABAA receptors by farnesol through the neurosteroid sites.
Gc JB, Szlenk CT, Diyaolu A, Obi P, Wei H, Shi X, Gibson KM, Natesan S, Roullet JB.
Gc JB, et al.
Biophys J. 2023 Mar 7;122(5):849-867. doi: 10.1016/j.bpj.2023.01.032. Epub 2023 Jan 31.
Biophys J. 2023.
PMID: 36721367
Studies have shown that farnesol is present in the human brain and inhibits voltage-gated Ca(2+) channels at much lower concentrations than ethanol. Here we show that farnesol modulates the activity of gamma-aminobutyric acid type A receptors (GABA(A)Rs), some of which als …
Studies have shown that farnesol is present in the human brain and inhibits voltage-gated Ca(2+) channels at much lower concentration …