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Year Number of Results
1979 1
1981 1
1986 2
1989 1
1990 1
1991 1
1992 1
1993 2
1997 2
1998 3
1999 1
2002 3
2003 3
2004 4
2005 1
2006 1
2007 1
2008 1
2010 4
2011 5
2012 1
2013 1
2015 4
2016 2
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2020 1
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2024 3

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54 results

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Page 1
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Smith BD, Kaufman MD, Lu WP, Gupta A, Leary CB, Wise SC, Rutkoski TJ, Ahn YM, Al-Ani G, Bulfer SL, Caldwell TM, Chun L, Ensinger CL, Hood MM, McKinley A, Patt WC, Ruiz-Soto R, Su Y, Telikepalli H, Town A, Turner BA, Vogeti L, Vogeti S, Yates K, Janku F, Abdul Razak AR, Rosen O, Heinrich MC, Flynn DL. Smith BD, et al. Among authors: flynn dl. Cancer Cell. 2019 May 13;35(5):738-751.e9. doi: 10.1016/j.ccell.2019.04.006. Cancer Cell. 2019. PMID: 31085175 Free article.
Inhibition of ULK1/2 and KRAS G12C controls tumor growth in preclinical models of lung cancer.
Ghazi PC, O'Toole KT, Srinivas Boggaram S, Scherzer MT, Silvis MR, Zhang Y, Bogdan M, Smith BD, Lozano G, Flynn DL, Snyder EL, Kinsey CG, McMahon M. Ghazi PC, et al. Among authors: flynn dl. bioRxiv [Preprint]. 2024 Jun 17:2024.02.06.579200. doi: 10.1101/2024.02.06.579200. bioRxiv. 2024. Update in: Elife. 2024 Aug 30;13:RP96992. doi: 10.7554/eLife.96992. PMID: 38370808 Free PMC article. Updated. Preprint.
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Yu Y, Bogdan M, Noman MZ, Parpal S, Bartolini E, Van Moer K, Kleinendorst SC, Bilgrav Saether K, Trésaugues L, Silvander C, Lindström J, Simeon J, Timson MJ, Al-Hashimi H, Smith BD, Flynn DL, Alexeyenko A, Viklund J, Andersson M, Martinsson J, Pokrovskaja Tamm K, De Milito A, Janji B. Yu Y, et al. Among authors: flynn dl. Mol Oncol. 2024 Aug;18(8):1904-1922. doi: 10.1002/1878-0261.13619. Epub 2024 Mar 20. Mol Oncol. 2024. PMID: 38506049 Free PMC article.
Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Caldwell TM, Kaufman MD, Wise SC, Mi Ahn Y, Hood MM, Lu WP, Patt WC, Samarakoon T, Vogeti L, Vogeti S, Yates KM, Bulfer SL, Le Bourdonnec B, Smith BD, Flynn DL. Caldwell TM, et al. Among authors: flynn dl. Bioorg Med Chem Lett. 2022 Oct 15;74:128929. doi: 10.1016/j.bmcl.2022.128929. Epub 2022 Aug 9. Bioorg Med Chem Lett. 2022. PMID: 35961461 Free article.
AXL regulates mesothelioma proliferation and invasiveness.
Ou WB, Corson JM, Flynn DL, Lu WP, Wise SC, Bueno R, Sugarbaker DJ, Fletcher JA. Ou WB, et al. Among authors: flynn dl. Oncogene. 2011 Apr 7;30(14):1643-52. doi: 10.1038/onc.2010.555. Epub 2010 Dec 6. Oncogene. 2011. PMID: 21132014
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT).
Caldwell TM, Ahn YM, Bulfer SL, Leary CB, Hood MM, Lu WP, Vogeti L, Vogeti S, Kaufman MD, Wise SC, Le Bourdonnec B, Smith BD, Flynn DL. Caldwell TM, et al. Among authors: flynn dl. Bioorg Med Chem Lett. 2022 Oct 15;74:128928. doi: 10.1016/j.bmcl.2022.128928. Epub 2022 Aug 10. Bioorg Med Chem Lett. 2022. PMID: 35961460 Free article.
Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages.
Smith BD, Kaufman MD, Wise SC, Ahn YM, Caldwell TM, Leary CB, Lu WP, Tan G, Vogeti L, Vogeti S, Wilky BA, Davis LE, Sharma M, Ruiz-Soto R, Flynn DL. Smith BD, et al. Among authors: flynn dl. Mol Cancer Ther. 2021 Nov;20(11):2098-2109. doi: 10.1158/1535-7163.MCT-21-0361. Epub 2021 Aug 25. Mol Cancer Ther. 2021. PMID: 34433663 Free PMC article.
54 results