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2,501 results

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Page 1
Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise.
Kuramoto K, Liang H, Hong JH, He C. Kuramoto K, et al. Cell Metab. 2023 Apr 4;35(4):620-632.e5. doi: 10.1016/j.cmet.2023.01.011. Epub 2023 Feb 21. Cell Metab. 2023. PMID: 36812915 Free PMC article.
Muscle-secreted FN1 mediates exercise-induced hepatic autophagy and systemic insulin sensitization via the hepatic receptor alpha5beta1 integrin and the downstream IKKalpha/beta-JNK1-BECN1 pathway. Thus, we demonstrate that hepatic autophagy activation drives exercise-indu …
Muscle-secreted FN1 mediates exercise-induced hepatic autophagy and systemic insulin sensitization via the hepatic receptor alpha5bet …
Rare genetic variation in fibronectin 1 (FN1) protects against APOEepsilon4 in Alzheimer's disease.
Bhattarai P, Gunasekaran TI, Belloy ME, Reyes-Dumeyer D, Jülich D, Tayran H, Yilmaz E, Flaherty D, Turgutalp B, Sukumar G, Alba C, McGrath EM, Hupalo DN, Bacikova D, Le Guen Y, Lantigua R, Medrano M, Rivera D, Recio P, Nuriel T, Ertekin-Taner N, Teich AF, Dickson DW, Holley S, Greicius M, Dalgard CL, Zody M, Mayeux R, Kizil C, Vardarajan BN. Bhattarai P, et al. Acta Neuropathol. 2024 Apr 10;147(1):70. doi: 10.1007/s00401-024-02721-1. Acta Neuropathol. 2024. PMID: 38598053 Free PMC article.
The FN1 and COL6A2 protein levels were increased at the BBB in APOEepsilon4 carriers with AD. ...To validate our findings, we used zebrafish models with loss-of-function (LOF) mutations in fn1b-the ortholog for human FN1. We found that fibronectin LOF reduced gliosi …
The FN1 and COL6A2 protein levels were increased at the BBB in APOEepsilon4 carriers with AD. ...To validate our findings, we used ze …
Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC.
Liu X, Meng L, Li X, Li D, Liu Q, Chen Y, Li X, Bu W, Sun H. Liu X, et al. Int J Oral Sci. 2020 Dec 14;12(1):34. doi: 10.1038/s41368-020-00101-5. Int J Oral Sci. 2020. PMID: 33318468 Free PMC article.
Data from SCC-25 cells demonstrated that rapamycin and Earle's balanced salt solution (EBSS) promoted autophagy, leading to increased FN1 degradation, while 3-methyladenine (3-MA), bafilomycin A1 (Baf A1) and chloroquine (CQ) inhibited autophagy, leading to decreased FN …
Data from SCC-25 cells demonstrated that rapamycin and Earle's balanced salt solution (EBSS) promoted autophagy, leading to increased FN1 …
Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis.
Liu YJ, Wang W, Yeh J, Wu Y, Mantilla JG, Fletcher CDM, Ricciotti RW, Chen EY. Liu YJ, et al. Mod Pathol. 2021 Jul;34(7):1373-1383. doi: 10.1038/s41379-021-00786-x. Epub 2021 Mar 16. Mod Pathol. 2021. PMID: 33727696 Free article.
We detected gene fusions in ten cases, including three novel fusions, FN1-MERTK, FN1-NTRK1, and FN1-TEK, each in one case, recurrent FN1-FGFR2 fusion in five cases, FN1-FGFR1 in one case, and FGFR1-PLAG1 in one case. The breakpoints in the 5' pa …
We detected gene fusions in ten cases, including three novel fusions, FN1-MERTK, FN1-NTRK1, and FN1-TEK, each in one ca …
Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1/AKT/FN1 signalling pathway.
Chen T, Song P, He M, Rui S, Duan X, Ma Y, Armstrong DG, Deng W. Chen T, et al. Burns Trauma. 2023 May 23;11:tkad003. doi: 10.1093/burnst/tkad003. eCollection 2023. Burns Trauma. 2023. PMID: 37251708 Free PMC article.
Bioinformatics analysis and proteomics indicated that fibronectin 1 (FN1) was closely related to S1PR1 due to its colocalization in the endothelial cells of human skin. Further study supported that FN1 plays an important role in the PRP-Exos-S1P-mediated S1PR1/prote …
Bioinformatics analysis and proteomics indicated that fibronectin 1 (FN1) was closely related to S1PR1 due to its colocalization in t …
[Soft tissue tumours with FN1 (Fibronectin 1) fusion gene].
Bouvier C, Nihous H, Macagno N. Bouvier C, et al. Ann Pathol. 2022 Apr;42(3):242-248. doi: 10.1016/j.annpat.2022.01.018. Epub 2022 Feb 15. Ann Pathol. 2022. PMID: 35181149 Review. French.
Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or without calcifications and a good prognosis. ...
Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or …
Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
Chen J, Rao B, Huang Z, Xie C, Yu Y, Yang B, Wu D, Wang D, Qiu F, Zhou Y, Deng Y, Lu J. Chen J, et al. J Transl Med. 2024 Jan 12;22(1):47. doi: 10.1186/s12967-023-04812-1. J Transl Med. 2024. PMID: 38216996 Free PMC article.
A comprehensive examination exposed the interaction between hsa_circ_0050386 and RNA binding protein Serine and arginine-rich splicing factor 3 (SRSF3), resulting in the down-regulation of Fibronectin 1 (FN1) expression, which inhibits the progression of NSCLC. CONCLUSIONS …
A comprehensive examination exposed the interaction between hsa_circ_0050386 and RNA binding protein Serine and arginine-rich splicing facto …
High FN1 expression correlates with gastric cancer progression.
Li J, Chen C, Chen B, Guo T. Li J, et al. Pathol Res Pract. 2022 Nov;239:154179. doi: 10.1016/j.prp.2022.154179. Epub 2022 Oct 18. Pathol Res Pract. 2022. PMID: 36274380
In tumor tissues, FN1 is mostly distributed in the stroma. High E-FN1 expression was associated with a decreased overall survival (OS), while S-FN1 expression did not. ...CONCLUSIONS: High E-FN1 expression predicted poor OS, while S-FN1 is assoc …
In tumor tissues, FN1 is mostly distributed in the stroma. High E-FN1 expression was associated with a decreased overall survi …
Mesoderm FN1 shaping the heart.
David DJV. David DJV. Nat Cell Biol. 2025 Feb;27(2):175. doi: 10.1038/s41556-025-01630-z. Nat Cell Biol. 2025. PMID: 39948268 No abstract available.
Fn1 Regulates the Third Pharyngeal Pouch Patterning and Morphogenesis.
Wang X, Liang Y, Zhu Z, Li W, Shi B, Deng Y, Li C, Sha O. Wang X, et al. J Dent Res. 2022 Aug;101(9):1082-1091. doi: 10.1177/00220345221078775. Epub 2022 Mar 8. J Dent Res. 2022. PMID: 35259939
In this study, we showed that fibronectin 1 (Fn1), which is synthesized by NCCs, modulates the functions of NCCs in the third pharyngeal pouch patterning and in the morphogenesis of the thymus/parathyroid. Loss of Fn1 in NCCs leads to decreased Foxn1 expression in t …
In this study, we showed that fibronectin 1 (Fn1), which is synthesized by NCCs, modulates the functions of NCCs in the third pharyng …
2,501 results