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142 results

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Page 1
FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease.
You Y, Liu C, Liu T, Tian M, Wu N, Yu Z, Zhao F, Qi J, Zhu Q. You Y, et al. Free Radic Biol Med. 2022 Nov 20;193(Pt 2):808-819. doi: 10.1016/j.freeradbiomed.2022.10.322. Epub 2022 Nov 3. Free Radic Biol Med. 2022. PMID: 36336231
In vitro, FNDC3B expression was negatively regulated by miR-192-5p. Furthermore, FNDC3B deletion significantly exacerbated ethanol-mediated lipid peroxidation. ...Our findings indicate that FNDC3B is a potential therapeutic target for ALD....
In vitro, FNDC3B expression was negatively regulated by miR-192-5p. Furthermore, FNDC3B deletion significantly exacerbated eth …
FNDC3B promotes gastric cancer metastasis via interacting with FAM83H and preventing its proteasomal degradation.
Zhang Y, Ran L, Liu Y, Li W, Ran A, Li H, Huang B, Ren J, Ning H, Ma Q, Wang X, Yang F, Pan X, Liang C, Wang S, Qin C, Jiang Y, Qian K, Xiao B. Zhang Y, et al. Cell Mol Biol Lett. 2025 May 31;30(1):65. doi: 10.1186/s11658-025-00741-7. Cell Mol Biol Lett. 2025. PMID: 40450207 Free PMC article.
In vitro cellular experiments and in vivo nude mouse models were constructed to validate the biological functions of FNDC3B. Truncated mutants of FNDC3B and immunofluorescence (IF) assays were conducted to explore the critical domains of FNDC3B. ...RESULTS: …
In vitro cellular experiments and in vivo nude mouse models were constructed to validate the biological functions of FNDC3B. Truncate …
Genetics of glaucoma.
Wiggs JL, Pasquale LR. Wiggs JL, et al. Hum Mol Genet. 2017 Aug 1;26(R1):R21-R27. doi: 10.1093/hmg/ddx184. Hum Mol Genet. 2017. PMID: 28505344 Free PMC article. Review.
Recent GWAS completed for three types of common adult-onset glaucoma have identified novel loci for POAG (primary-open-angle glaucoma) (ABCA1, AFAP1, GMDS, PMM2, TGFBR3, FNDC3B, ARHGEF12, GAS7, FOXC1, ATXN2, TXNRD2); PACG (primary angle-closure glaucoma (EPDR1, CHAT, GLIS3 …
Recent GWAS completed for three types of common adult-onset glaucoma have identified novel loci for POAG (primary-open-angle glaucoma) (ABCA …
FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.
Li YQ, Chen Y, Xu YF, He QM, Yang XJ, Li YQ, Hong XH, Huang SY, Tang LL, Liu N. Li YQ, et al. Cancer Sci. 2020 Jun;111(6):1991-2003. doi: 10.1111/cas.14394. Epub 2020 May 19. Cancer Sci. 2020. PMID: 32232887 Free PMC article.
Overexpression of FNDC3B, especially those with shorter 3'-UTR, promoted NPC progression. Furthermore, the mechanism study revealed that FNDC3B could bind to and stabilize myosin heavy chain 9 (MYH9) to activate the Wnt/beta-catenin signaling pathway. In addition, M …
Overexpression of FNDC3B, especially those with shorter 3'-UTR, promoted NPC progression. Furthermore, the mechanism study revealed t …
FNDC3B is associated with ER stress and poor prognosis in cervical cancer.
Han B, Wang H, Zhang J, Tian J. Han B, et al. Oncol Lett. 2020 Jan;19(1):406-414. doi: 10.3892/ol.2019.11098. Epub 2019 Nov 14. Oncol Lett. 2020. PMID: 31897153 Free PMC article.
Correlations between FNDC3B expression and overall survival were subsequently investigated. The results revealed that increased FNDC3B expression was significantly correlated with a lower overall survival in patients with cervical cancer. ...Furthermore, immunofluor …
Correlations between FNDC3B expression and overall survival were subsequently investigated. The results revealed that increased FN …
Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.
Zeng Q, Ji X, Li X, Tian Y. Zeng Q, et al. Hum Exp Toxicol. 2023 Jan-Dec;42:9603271221141689. doi: 10.1177/09603271221141689. Hum Exp Toxicol. 2023. PMID: 36738165 Free article.
METHODS: Quantitative PCR (RT-qPCR) was applied for detecting the expression of circ_0000285, miR-1278, and FNDC3B. Western blot was used to measure the protein levels of Fibronectin type III domain containing 3B (FNDC3B), Bcl2 associated X (Bax), and B cell leukemi …
METHODS: Quantitative PCR (RT-qPCR) was applied for detecting the expression of circ_0000285, miR-1278, and FNDC3B. Western blot was …
Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p.
Zhang Y, Xiong W, Yang C, Li P, Tong H. Zhang Y, et al. Biochem Genet. 2023 Oct;61(5):1917-1936. doi: 10.1007/s10528-023-10354-4. Epub 2023 Mar 8. Biochem Genet. 2023. PMID: 36884165
In vivo research was conducted via xenograft model in mice. Circ-FNDC3B exhibited significant upregulation in ESCC tissues and cells. Downregulation of circ-FNDC3B inhibited ESCC cell proliferation and invasion but accelerated cell apoptosis. Circ-FNDC3B inte …
In vivo research was conducted via xenograft model in mice. Circ-FNDC3B exhibited significant upregulation in ESCC tissues and cells. …
FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma.
Lin CH, Lin YW, Chen YC, Liao CC, Jou YS, Hsu MT, Chen CF. Lin CH, et al. Oncotarget. 2016 Aug 2;7(31):49498-49508. doi: 10.18632/oncotarget.10374. Oncotarget. 2016. PMID: 27385217 Free PMC article.
We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in HCC metastasis. Overexpression of FNDC3B in HCC cell lines enhanced cell migration and invasion. ...Our results indicate that FNDC3B behaves like an oncogene by promoting cell m …
We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in HCC metastasis. Overexpression of FNDC3B in …
FNDC3B, Targeted by miR-125a-5p and miR-217, Promotes the Proliferation and Invasion of Colorectal Cancer Cells via PI3K/mTOR Signaling.
Li Y, Yang J, Wang H, Qiao W, Guo Y, Zhang S, Guo Y. Li Y, et al. Onco Targets Ther. 2020 Apr 30;13:3501-3510. doi: 10.2147/OTT.S226520. eCollection 2020. Onco Targets Ther. 2020. PMID: 32431508 Free PMC article.
BACKGROUND: Fibronectin type III domain containing 3B (FNDC3B) acts as an oncogene in various cancers, and abnormal expression of FNDC3B has been found in colorectal cancer (CRC). ...The novel miR-125a-5p/FNDC3B and miR-217/FNDC3B axes might be new tar …
BACKGROUND: Fibronectin type III domain containing 3B (FNDC3B) acts as an oncogene in various cancers, and abnormal expression of …
FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer.
Zhang L, Yu H, Deng T, Ling L, Wen J, Lv M, Ou R, Wang Q, Xu Y. Zhang L, et al. Front Oncol. 2021 Dec 16;11:783868. doi: 10.3389/fonc.2021.783868. eCollection 2021. Front Oncol. 2021. PMID: 34976823 Free PMC article.
In patients with CCa, a higher expression of FNDC3B or lower expression of BPGM was closely correlated with a shorter overall survival (OS) and disease-free survival (DFS). A receiver operating characteristic (ROC) analysis of CIN and CCa showed that FNDC3B had the …
In patients with CCa, a higher expression of FNDC3B or lower expression of BPGM was closely correlated with a shorter overall surviva …
142 results