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47 results

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Page 1
FOXN2 suppresses the proliferation and invasion of human hepatocellular carcinoma cells.
Liu XH, Liu LP, Xu XM, Hua M, Kang Q, Li A, Huang L. Liu XH, et al. Eur Rev Med Pharmacol Sci. 2021 Jan;25(2):731-737. doi: 10.26355/eurrev_202101_24634. Eur Rev Med Pharmacol Sci. 2021. PMID: 33577027 Free article.
PATIENTS AND METHODS: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to determine expression of FOXN2 in HCC tissues and cells. Transfection of plasmid containing FOXN2 was used to exogenously overexpress FOXN2 in vitro. ...CONCLUSIONS: …
PATIENTS AND METHODS: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to determine expression of FOXN2 in HCC tis …
Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner.
Song Y, Lian S, Fan H, Ma C, Zheng L, Huang F, Huang S, Tang Y, Shi A, Shu L, Zhao L, Xu Y, Guo S, Liu Z, Zhang Z. Song Y, et al. Cancer Lett. 2024 Jun 28;592:216921. doi: 10.1016/j.canlet.2024.216921. Epub 2024 May 4. Cancer Lett. 2024. PMID: 38705565 Free article.
In our study, we assessed the correlation of Bmi1 and Foxn2 expression across all types of CCA and evaluated their prognostic significance. Our results demonstrated that Bmi1 exhibits significantly upregulated expression in CCA tissues, while Foxn2 expression shows …
In our study, we assessed the correlation of Bmi1 and Foxn2 expression across all types of CCA and evaluated their prognostic signifi …
FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer.
Li L, Sun X, Zhang M, Zhang B, Yang Y, Wang S. Li L, et al. Growth Factors. 2024 May;42(2):62-73. doi: 10.1080/08977194.2023.2297700. Epub 2024 Mar 4. Growth Factors. 2024. PMID: 38954805
BACKGROUND AND OBJECTIVE: Dysregulated expression of Forkhead Box N2 (FOXN2) has been detected in various cancer types. However, the underlying mechanisms by which FOXN2 contributes to the onset and progression of gastric cancer (GC) remain largely unexplored. ... …
BACKGROUND AND OBJECTIVE: Dysregulated expression of Forkhead Box N2 (FOXN2) has been detected in various cancer types. However, the …
FOXN2 is downregulated in breast cancer and regulates migration, invasion, and epithelial- mesenchymal transition through regulation of SLUG.
Ye H, Duan M. Ye H, et al. Cancer Manag Res. 2019 Jan 4;11:525-535. doi: 10.2147/CMAR.S176938. eCollection 2019. Cancer Manag Res. 2019. PMID: 30655703 Free PMC article.
However, the expression and function of FOXN2 in breast cancer remain unclear. METHODS: In the present work, we explored the detailed molecular mechanism of FOXN2 in breast cancer. ...RESULTS: Our results demonstrated that FOXN2 was downregulated in breast ca …
However, the expression and function of FOXN2 in breast cancer remain unclear. METHODS: In the present work, we explored the detailed …
HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2.
Jeong S, Kim SA, Ahn SG. Jeong S, et al. Int J Mol Sci. 2021 Dec 21;23(1):9. doi: 10.3390/ijms23010009. Int J Mol Sci. 2021. PMID: 35008435 Free PMC article.
Overexpression of mir-188-5p inhibited the expression of forkhead box N2 (FOXN2), a tumor suppressor gene. Furthermore, in the luciferase assay, miR-188-5p bound to the 3'-UTR of FOXN2 and was mainly responsible for the dysregulation of FOXN2 expression. Sile …
Overexpression of mir-188-5p inhibited the expression of forkhead box N2 (FOXN2), a tumor suppressor gene. Furthermore, in the lucife …
Transcriptomic integration nominates FOXN2 as a candidate schizophrenia risk gene.
Yu L, Chen J, Du S, Long Q, Guo Z, Liu Y, Qin F, Wang M, Luo R, Zhang Y, Zeng Y, Teng Z. Yu L, et al. Behav Brain Res. 2026 Apr 27;504:116068. doi: 10.1016/j.bbr.2026.116068. Epub 2026 Jan 28. Behav Brain Res. 2026. PMID: 41616909
RESULTS: Cross-tissue integration of TWAS, MAGMA, and SMR identified five convergent schizophrenia susceptibility genes: TVP23B, NSUN2, RPL12, FOXN2, and THAP5. Bayesian colocalization analysis highlighted FOXN2 as the most robust candidate (PP.H4 =0.995). ...CONCLU …
RESULTS: Cross-tissue integration of TWAS, MAGMA, and SMR identified five convergent schizophrenia susceptibility genes: TVP23B, NSUN2, RPL1 …
beta-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.
Ma J, Lu Y, Zhang S, Li Y, Huang J, Yin Z, Ren J, Huang K, Liu L, Yang K, Wu G, Xu S. Ma J, et al. Cell Death Differ. 2018 Aug;25(8):1473-1485. doi: 10.1038/s41418-017-0055-6. Epub 2018 Feb 2. Cell Death Differ. 2018. PMID: 29396548 Free PMC article.
However, the underlying mechanisms of FOXN2 deregulation in tumorigenesis remain largely unknown. Here, we find that FOXN2 binds to and is ubiquitinated by beta-Trcp ubiquitin ligase and RSK2 kinase for degradation. ...Importantly, beta-Trcp-mediated and RSK2-mediat …
However, the underlying mechanisms of FOXN2 deregulation in tumorigenesis remain largely unknown. Here, we find that FOXN2 bin …
Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression.
Wang H, Liang C, Lin J, Dong Y, Wang Y, Xia L. Wang H, et al. Mol Biotechnol. 2024 Jun;66(6):1477-1483. doi: 10.1007/s12033-023-00773-4. Epub 2023 Jun 15. Mol Biotechnol. 2024. PMID: 37318741
The luciferase reporter outputs verified miR-188-5p and FOXN2 as hsa_circ_0001741 downstream targets. FOXN2 silencing or miR-188-5p upregulations reversed inhibitory effects regarding hsa_circ_0001741 on OC cell proliferation. Therefore our data suggested that hsa_c …
The luciferase reporter outputs verified miR-188-5p and FOXN2 as hsa_circ_0001741 downstream targets. FOXN2 silencing or miR-1 …
Human FOX gene family (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Oncol. 2004 Nov;25(5):1495-500. Int J Oncol. 2004. PMID: 15492844 Review.
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOX …
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD …
The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network.
Rho HK, McClay DR. Rho HK, et al. Development. 2011 Mar;138(5):937-45. doi: 10.1242/dev.058396. Development. 2011. PMID: 21303847 Free PMC article.
Here, we show that Pmar1, Ets1 and Tbr are necessary for activation of foxN2/3 in micromeres. The later endomesoderm expression of foxN2/3 is independent of the earlier expression of foxN2/3 in micromeres and is independent of signals from PMCs. ...Knockdown …
Here, we show that Pmar1, Ets1 and Tbr are necessary for activation of foxN2/3 in micromeres. The later endomesoderm expression of …
47 results