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Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3.
Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF. Sanghani SP, et al. Among authors: fredenburg tb. Drug Metab Dispos. 2004 May;32(5):505-11. doi: 10.1124/dmd.32.5.505. Drug Metab Dispos. 2004. PMID: 15100172