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Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.

Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE. Dar HH, et al. Among authors: freedman cj. J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10. J Clin Invest. 2018. PMID: 30198910 Free PMC article.

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Early Use of High-Dose Glucocorticoid for the Management of irAE Is Associated with Poorer Survival in Patients with Advanced Melanoma Treated with Anti-PD-1 Monotherapy.

Bai X, Hu J, Betof Warner A, Quach HT, Cann CG, Zhang MZ, Si L, Tang B, Cui C, Yang X, Wei X, Pallan L, Harvey C, Manos MP, Ouyang O, Kim MS, Kasumova G, Cohen JV, Lawrence DP, Freedman C, Fadden RM, Rubin KM, Sharova T, Frederick DT, Flaherty KT, Rahma OE, Long GV, Menzies AM, Guo J, Shoushtari AN, Johnson DB, Sullivan RJ, Boland GM. Bai X, et al. Among authors: freedman c. Clin Cancer Res. 2021 Nov 1;27(21):5993-6000. doi: 10.1158/1078-0432.CCR-21-1283. Epub 2021 Aug 10. Clin Cancer Res. 2021. PMID: 34376536

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DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.

Yamaguchi A, Stanger L, Freedman CJ, Standley M, Hoang T, Adili R, Tsai WC, van Hoorebeke C, Holman TR, Holinstat M. Yamaguchi A, et al. Among authors: freedman cj. J Thromb Haemost. 2021 Mar;19(3):839-851. doi: 10.1111/jth.15184. Epub 2020 Dec 16. J Thromb Haemost. 2021. PMID: 33222370 Free PMC article.

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High-speed handling of a haemorrhage control system by first-responders and physicians.

Reuter PG, Tepper S, Akodad H, Lesecq A, Freedman C, Agostinucci JM, Petrovic T, Adnet F, Lapostolle F. Reuter PG, et al. Among authors: freedman c. Am J Emerg Med. 2020 Apr;38(4):838-839. doi: 10.1016/j.ajem.2019.158498. Epub 2019 Oct 14. Am J Emerg Med. 2020. PMID: 31806267 No abstract available.

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Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.

Ellison V, Annor GK, Freedman C, Xiao G, Lundine D, Freulich E, Prives C, Bargonetti J. Ellison V, et al. Among authors: freedman c. Oncotarget. 2021 Jun 8;12(12):1128-1146. doi: 10.18632/oncotarget.27975. eCollection 2021 Jun 8. Oncotarget. 2021. PMID: 34136083 Free PMC article.

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Radiological dynamics and SITC-defined resistance types of advanced melanoma during anti-PD-1 monotherapy: an independent single-blind observational study on an international cohort.

Bai X, Kim M, Kasumova G, Si L, Tang B, Cui C, Yang X, Wei X, Cohen J, Lawrence D, Freedman C, Fadden R, Rubin K, Sharova T, Frederick D, Flaherty K, Sullivan R, Guo J, Boland G. Bai X, et al. Among authors: freedman c. J Immunother Cancer. 2021 Feb;9(2):e002092. doi: 10.1136/jitc-2020-002092. J Immunother Cancer. 2021. PMID: 33632901 Free PMC article.

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Omega-6 DPA and its 12-lipoxygenase-oxidized lipids regulate platelet reactivity in a nongenomic PPARα-dependent manner.

Yeung J, Adili R, Yamaguchi A, Freedman CJ, Chen A, Shami R, Das A, Holman TR, Holinstat M. Yeung J, et al. Among authors: freedman cj. Blood Adv. 2020 Sep 22;4(18):4522-4537. doi: 10.1182/bloodadvances.2020002493. Blood Adv. 2020. PMID: 32946570 Free PMC article.

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Hagfish Houdinis: biomechanics and behavior of squeezing through small openings.

Freedman CR, Fudge DS. Freedman CR, et al. J Exp Biol. 2017 Mar 1;220(Pt 5):822-827. doi: 10.1242/jeb.151233. Epub 2017 Jan 13. J Exp Biol. 2017. PMID: 28087655

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Surgical treatment outcomes of infantile hemangioma in children: Does prior medical treatment matter.

Tangtatco JA, Freedman C, Phillips J, Pope E. Tangtatco JA, et al. Among authors: freedman c. Pediatr Dermatol. 2018 Nov;35(6):e418-e419. doi: 10.1111/pde.13658. Epub 2018 Sep 6. Pediatr Dermatol. 2018. PMID: 30187523

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Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.

Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR. Freedman C, et al. Biochemistry. 2020 May 19;59(19):1832-1844. doi: 10.1021/acs.biochem.0c00233. Epub 2020 May 7. Biochemistry. 2020. PMID: 32324389 Free PMC article.

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