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Blastocyst-like structures generated solely from stem cells.
Rivron NC, Frias-Aldeguer J, Vrij EJ, Boisset JC, Korving J, Vivié J, Truckenmüller RK, van Oudenaarden A, van Blitterswijk CA, Geijsen N. Rivron NC, et al. Among authors: frias aldeguer j. Nature. 2018 May;557(7703):106-111. doi: 10.1038/s41586-018-0051-0. Epub 2018 May 2. Nature. 2018. PMID: 29720634
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero.
Seong J, Frias-Aldeguer J, Holzmann V, Kagawa H, Sestini G, Heidari Khoei H, Scholte Op Reimer Y, Kip M, Pradhan SJ, Verwegen L, Vivié J, Li L, Alemany A, Korving J, Darmis F, van Oudenaarden A, Ten Berge D, Geijsen N, Rivron NC. Seong J, et al. Among authors: frias aldeguer j. Cell Stem Cell. 2022 Jul 7;29(7):1102-1118.e8. doi: 10.1016/j.stem.2022.06.002. Cell Stem Cell. 2022. PMID: 35803228 Free article.
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Vrij EJ, Scholte Op Reimer YS, Roa Fuentes L, Misteli Guerreiro I, Holzmann V, Frias Aldeguer J, Sestini G, Koo BK, Kind J, van Blitterswijk CA, Rivron NC. Vrij EJ, et al. Among authors: frias aldeguer j. Development. 2022 Oct 15;149(20):dev192310. doi: 10.1242/dev.192310. Epub 2022 Aug 22. Development. 2022. PMID: 35993866 Free PMC article.
Stem cells & pancreatic cancer.
García-Silva S, Frias-Aldeguer J, Heeschen C. García-Silva S, et al. Among authors: frias aldeguer j. Pancreatology. 2013 Mar-Apr;13(2):110-3. doi: 10.1016/j.pan.2012.12.003. Pancreatology. 2013. PMID: 23561967
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.
Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H. Basak O, et al. Among authors: frias aldeguer j. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E610-E619. doi: 10.1073/pnas.1715911114. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311336 Free PMC article.