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Copper and protons directly activate the zinc-activated channel.
Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. Trattnig SM, et al. Among authors: gasiorek a. Biochem Pharmacol. 2016 Mar 1;103:109-17. doi: 10.1016/j.bcp.2016.02.004. Epub 2016 Feb 9. Biochem Pharmacol. 2016. PMID: 26872532 Free PMC article.