Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy.
Chan JSF, Tabatabaei Dakhili SA, Wu NR, Stenlund MJ, King AN, Dong L, Mangra-Bala IA, Shafaati T, Ferrari SR, Greenwell AA, Yang K, Saed CT, Eaton F, Gopal K, Steinberg GR, Dyck JRB, Ussher JR.
Chan JSF, et al.
J Mol Cell Cardiol Plus. 2025 Nov 14;14:100825. doi: 10.1016/j.jmccpl.2025.100825. eCollection 2025 Dec.
J Mol Cell Cardiol Plus. 2025.
PMID: 41362917
Free PMC article.
The animals' drinking water was randomized to include either vehicle control or metformin (3.0 g/L) during the final 7.5 weeks. As expected, metformin treatment improved glycemia with a trend towards a reduction in adiposity in mice with T2D. ...
The animals' drinking water was randomized to include either vehicle control or metformin (3.0 g/L) during the final 7.5 weeks. As ex …