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Page 1
Synthesis of Novel Vindoline-Chrysin Hybrids.
Mayer S, Nagy N, Keglevich P, Szigetvári Á, Dékány M, Szántay Junior C, Hazai L. Mayer S, et al. Chem Biodivers. 2022 Jan;19(1):e202100725. doi: 10.1002/cbdv.202100725. Epub 2021 Dec 7. Chem Biodivers. 2022. PMID: 34874114
Chrysin had shown synergic effect with several antiproliferative compounds (e. g., doxorubicin, cisplatin and ciglitazone), therefore, we attempted the synthesis of a novel vindoline-chrysin hybrid molecule. ...
Chrysin had shown synergic effect with several antiproliferative compounds (e. g., doxorubicin, cisplatin and ciglitazone), therefore …
Ultrahigh-Resolution Homo- and Heterodecoupled 1H and TOCSY NMR Experiments.
Timári I, Bagi P, Keglevich G, E Kövér K. Timári I, et al. ACS Omega. 2022 Nov 15;7(47):43283-43289. doi: 10.1021/acsomega.2c06102. eCollection 2022 Nov 29. ACS Omega. 2022. PMID: 36467931 Free PMC article.
The original homonuclear decoupled (pure shift) experiments provide ultrahigh-resolution (1)H spectra of compounds containing NMR-active heteronuclei of low natural isotopic abundance (e.g., (13)C or (15)N). In contrast, molecules containing highly abundant heteronuclei (l …
The original homonuclear decoupled (pure shift) experiments provide ultrahigh-resolution (1)H spectra of compounds containing NMR-active het …
Microwave-Assisted Ionic Liquid-Catalyzed Selective Monoesterification of Alkylphosphonic Acids-An Experimental and a Theoretical Study.
Harsági N, Henyecz R, Ábrányi-Balogh P, Drahos L, Keglevich G. Harsági N, et al. Molecules. 2021 Aug 31;26(17):5303. doi: 10.3390/molecules26175303. Molecules. 2021. PMID: 34500735 Free PMC article.
The method developed is a green method for P-acid esterification. DFT calculations at the M062X/6-311+G (d,p) level of theory (performed considering the solvent effect of the corresponding alcohol) explored the three-step mechanism, and justified a higher enthalpy of activ …
The method developed is a green method for P-acid esterification. DFT calculations at the M062X/6-311+G (d,p) level of theory (perfor …
The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell-penetrating peptide.
Bánóczi Z, Keglevich A, Szabó I, Ranđelović I, Hegedüs Z, Regenbach FL, Keglevich P, Lengyel Z, Gorka-Kereskényi Á, Dubrovay Z, Háda V, Szigetvári Á, Szántay C Jr, Hazai L, Tóvári J, Hudecz F. Bánóczi Z, et al. J Pept Sci. 2018 Oct;24(10):e3118. doi: 10.1002/psc.3118. Epub 2018 Aug 6. J Pept Sci. 2018. PMID: 30084214 Free article.
Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new vindoline derivatives with moderate cytostatic activity. ...
Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our nov …