The effect of conjugation on antitumor activity of vindoline derivatives with octaarginine, a cell-penetrating peptide.
Bánóczi Z, Keglevich A, Szabó I, Ranđelović I, Hegedüs Z, Regenbach FL, Keglevich P, Lengyel Z, Gorka-Kereskényi Á, Dubrovay Z, Háda V, Szigetvári Á, Szántay C Jr, Hazai L, Tóvári J, Hudecz F.
Bánóczi Z, et al.
J Pept Sci. 2018 Oct;24(10):e3118. doi: 10.1002/psc.3118. Epub 2018 Aug 6.
J Pept Sci. 2018.
PMID: 30084214
Free article.
Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new vindoline derivatives with moderate cytostatic activity. ...
Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our nov …