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CPV of the Future: AI-powered continued process verification for bioreactor processes.
Ondracka A, Gasset A, García-Ortega X, Hubmayr D, van Wijngaarden JBG, Montesinos-Seguí JL, Valero F, Manzano T. Ondracka A, et al. Among authors: garcia ortega x. PDA J Pharm Sci Technol. 2022 Sep 19:pdajpst.2021.012665. doi: 10.5731/pdajpst.2021.012665. Online ahead of print. PDA J Pharm Sci Technol. 2022. PMID: 36122916
The effect of hypoxia on the lipidome of recombinant Pichia pastoris.
Adelantado N, Tarazona P, Grillitsch K, García-Ortega X, Monforte S, Valero F, Feussner I, Daum G, Ferrer P. Adelantado N, et al. Among authors: garcia ortega x. Microb Cell Fact. 2017 May 19;16(1):86. doi: 10.1186/s12934-017-0699-4. Microb Cell Fact. 2017. PMID: 28526017 Free PMC article.
Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris.
Garrigós-Martínez J, Vuoristo K, Nieto-Taype MA, Tähtiharju J, Uusitalo J, Tukiainen P, Schmid C, Tolstorukov I, Madden K, Penttilä M, Montesinos-Seguí JL, Valero F, Glieder A, Garcia-Ortega X. Garrigós-Martínez J, et al. Among authors: garcia ortega x. Microb Cell Fact. 2021 Mar 23;20(1):74. doi: 10.1186/s12934-021-01564-9. Microb Cell Fact. 2021. PMID: 33757505 Free PMC article.
Rationale-based selection of optimal operating strategies and gene dosage impact on recombinant protein production in Komagataella phaffii (Pichia pastoris).
Nieto-Taype MA, Garrigós-Martínez J, Sánchez-Farrando M, Valero F, Garcia-Ortega X, Montesinos-Seguí JL. Nieto-Taype MA, et al. Among authors: garcia ortega x. Microb Biotechnol. 2020 Mar;13(2):315-327. doi: 10.1111/1751-7915.13498. Epub 2019 Oct 28. Microb Biotechnol. 2020. PMID: 31657146 Free PMC article.
Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) PAOX1-driven recombinant producer strains with different target gene dosage.
Garrigós-Martínez J, Nieto-Taype MA, Gasset-Franch A, Montesinos-Seguí JL, Garcia-Ortega X, Valero F. Garrigós-Martínez J, et al. Among authors: garcia ortega x. Microb Cell Fact. 2019 Nov 1;18(1):187. doi: 10.1186/s12934-019-1240-8. Microb Cell Fact. 2019. PMID: 31675969 Free PMC article.