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Page 1
GAS2L3: Coordinator of cardiomyocyte cytokinesis?
Gründl M, Engel FB, Gaubatz S. Gründl M, et al. Cell Cycle. 2017 Oct 18;16(20):1853-1854. doi: 10.1080/15384101.2017.1372546. Epub 2017 Sep 22. Cell Cycle. 2017. PMID: 28937871 Free PMC article. No abstract available.
IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cells.
Zhao Y, Zheng M, Li P, Zhao C, Chen R, Qian B, Cui X, Ren Y, Su C, Shi L, Hao J, Yao Z, Gao X, Yang J. Zhao Y, et al. J Adv Res. 2025 Oct 31:S2090-1232(25)00859-8. doi: 10.1016/j.jare.2025.10.064. Online ahead of print. J Adv Res. 2025. PMID: 41177429 Free article.
However, the role of GAS2L3 in HCC pathogenesis remains unclear. OBJECTIVES: This study aimed to investigate the molecular mechanisms by which GAS2L3 contributes to cytokinesis and hyperproliferation of HCC cells. ...Notably, EGFP-GAS2L3 aggregates in the mid …
However, the role of GAS2L3 in HCC pathogenesis remains unclear. OBJECTIVES: This study aimed to investigate the molecular mechanisms …
Elevated GAS2L3 Expression Correlates With Poor Prognosis in Patients With Glioma: A Study Based on Bioinformatics and Immunohistochemical Analysis.
Zhou Y, Zhang L, Song S, Xu L, Yan Y, Wu H, Tong X, Yan H. Zhou Y, et al. Front Genet. 2021 Mar 30;12:649270. doi: 10.3389/fgene.2021.649270. eCollection 2021. Front Genet. 2021. PMID: 33859674 Free PMC article.
Abnormal GAS2L3 expression has been reported to be associated with carcinogenesis. However, the biological role of GAS2L3 in glioma remains to be determined. ...Bioinformatics analyses were conducted to explore biological functions and prognostic value of GAS2L3 …
Abnormal GAS2L3 expression has been reported to be associated with carcinogenesis. However, the biological role of GAS2L3 in g …
Gas2l3 is essential for brain morphogenesis and development.
Sharaby Y, Lahmi R, Amar O, Elbaz I, Lerer-Goldshtein T, Weiss AM, Appelbaum L, Tzur A. Sharaby Y, et al. Dev Biol. 2014 Oct 15;394(2):305-13. doi: 10.1016/j.ydbio.2014.08.006. Epub 2014 Aug 15. Dev Biol. 2014. PMID: 25131197 Free article.
Thus far, the role of Gas2l3 in vivo remains entirely unknown. In order to investigate Gas2l3 in developing vertebrates, we cloned the zebrafish gene. ...At the tissue level, gas2l3 downregulation interferes with cell proliferation, suggesting that the cell c …
Thus far, the role of Gas2l3 in vivo remains entirely unknown. In order to investigate Gas2l3 in developing vertebrates, we cl …
GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability.
Wolter P, Schmitt K, Fackler M, Kremling H, Probst L, Hauser S, Gruss OJ, Gaubatz S. Wolter P, et al. J Cell Sci. 2012 May 15;125(Pt 10):2393-406. doi: 10.1242/jcs.097253. Epub 2012 Feb 17. J Cell Sci. 2012. PMID: 22344256
Biochemical studies show that GAS2L3 binds to and bundles microtubules as well as F-actin in vitro. Strikingly, the RNAi-mediated knockdown of GAS2L3 results in chromosome segregation defects in multinucleated cells and in cells with multi-lobed nuclei. Likewise, ch …
Biochemical studies show that GAS2L3 binds to and bundles microtubules as well as F-actin in vitro. Strikingly, the RNAi-mediated kno …
Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex.
Pe'er T, Lahmi R, Sharaby Y, Chorni E, Noach M, Vecsler M, Zlotorynski E, Steen H, Steen JA, Tzur A. Pe'er T, et al. PLoS One. 2013;8(2):e57532. doi: 10.1371/journal.pone.0057532. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23469016 Free PMC article.
Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. ...We therefore suggest that Gas2l3 is part of the cellular mechanism that terminates cell division....
Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cyto …
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S. Stopp S, et al. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034. doi: 10.1073/pnas.1703406114. Epub 2017 Jul 11. Proc Natl Acad Sci U S A. 2017. PMID: 28698371 Free PMC article.
The in vivo function of GAS2L3 in mammals remains unknown. Here, we show that mice deficient in GAS2L3 die shortly after birth because of heart failure. ...Cardiomyocyte-specific deletion of GAS2L3 confirmed that the phenotype results from the loss of GAS2 …
The in vivo function of GAS2L3 in mammals remains unknown. Here, we show that mice deficient in GAS2L3 die shortly after birth …
Integrative analysis regarding the correlation between GAS2 family genes and human glioma prognosis.
Zhao C, Zhang N, Cui X, Zhang X, Ren Y, Su C, He J, Zhang W, Sun X, Yang J, Gao X. Zhao C, et al. Cancer Med. 2021 Apr;10(8):2826-2839. doi: 10.1002/cam4.3829. Epub 2021 Mar 12. Cancer Med. 2021. PMID: 33713047 Free PMC article.

Moreover, DNA hypomethylation status of GAS2L3 was correlated with the high expression of GAS2L3 in LGG tissues and the poor clinical prognosis of primary glioma cases (p < 0.05). ...Additionally, our cellular experiment data suggested that a highly expressed

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Moreover, DNA hypomethylation status of GAS2L3 was correlated with the high expression of GAS2L3 in LGG tissues and the poor c …
The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission.
Fackler M, Wolter P, Gaubatz S. Fackler M, et al. FEBS J. 2014 May;281(9):2123-35. doi: 10.1111/febs.12766. Epub 2014 Mar 13. FEBS J. 2014. PMID: 24571573 Free article.
GAS2L3 is a recently identified tubulin- and actin-binding protein that regulates cytokinesis and abscission. ...We find that the interaction between these two CPC subunits and GAS2L3 is mediated by the conserved GAR domain of GAS2L3. We further show that the …
GAS2L3 is a recently identified tubulin- and actin-binding protein that regulates cytokinesis and abscission. ...We find that the int …
28 results