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Year Number of Results
1999 1
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2002 1
2003 1
2004 1
2005 2
2006 2
2007 3
2008 5
2009 3
2011 2
2014 1
2015 4
2016 2
2017 3
2018 2
2019 5
2020 2
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Page 1
GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer.
Jeong H, Choi BH, Park J, Jung JH, Shin H, Kang KW, Quan YH, Yu J, Park JH, Park Y, Choi Y, Kim HK, Hong S. Jeong H, et al. Cancers (Basel). 2021 Oct 31;13(21):5482. doi: 10.3390/cancers13215482. Cancers (Basel). 2021. PMID: 34771645 Free PMC article.
Receiver operating characteristic curve analysis revealed the diagnostic sensitivity and specificity of exosomal GCC2 to be 90% and 75%, respectively. A high area under the curve, 0.844, confirmed that GCC2 levels could effectively distinguish between the exosomes. …
Receiver operating characteristic curve analysis revealed the diagnostic sensitivity and specificity of exosomal GCC2 to be 90% and 7 …
Rare GCC2-ALK fusion G13:A20 detected by next generation sequencing in non-small cell lung cancer patients and treatment response.
Qin J, Zeng D, Xie F, Yu R, Wu X, Liu K, Shao YW, Lu H, Jiang J. Qin J, et al. Transl Cancer Res. 2019 Sep;8(5):2187-2191. doi: 10.21037/tcr.2019.08.26. Transl Cancer Res. 2019. PMID: 35116968 Free PMC article.
Two patients with rare GCC2-ALK fusion G13:A20 which were found in Chinese population by next generation sequencing (NGS) developed resistant to crizotinib with a prolonged progression-free survival (PFS). ...In conclusion, non-small cell lung cancer (NSCLC) patients with …
Two patients with rare GCC2-ALK fusion G13:A20 which were found in Chinese population by next generation sequencing (NGS) developed r …
GCC2-ALK as a targetable fusion in lung adenocarcinoma and its enduring clinical responses to ALK inhibitors.
Jiang J, Wu X, Tong X, Wei W, Chen A, Wang X, Shao YW, Huang J. Jiang J, et al. Lung Cancer. 2018 Jan;115:5-11. doi: 10.1016/j.lungcan.2017.10.011. Epub 2017 Oct 27. Lung Cancer. 2018. PMID: 29290262
The functional study of GCC2-ALK was performed in Ba/F3 cells with cell proliferation and viability assays. ...Crizotinib treatment of the patient resulted in 18 months of progression free survival without any trace of GCC2-ALK fusion in the liquid biopsies. Re-biop …
The functional study of GCC2-ALK was performed in Ba/F3 cells with cell proliferation and viability assays. ...Crizotinib treatment o …
RANBP2 evolution and human disease.
Desgraupes S, Etienne L, Arhel NJ. Desgraupes S, et al. FEBS Lett. 2023 Oct;597(20):2519-2533. doi: 10.1002/1873-3468.14749. Epub 2023 Oct 15. FEBS Lett. 2023. PMID: 37795679 Review.
The chromosomal region containing the RANBP2 gene is highly dynamic, with high structural variation and recombination events that led to the appearance of a gene family called RANBP2 and GCC2 Protein Domains (RGPD), with multiple gene loss/duplication events during ape evo …
The chromosomal region containing the RANBP2 gene is highly dynamic, with high structural variation and recombination events that led to the …
Upregulation of Long Non-Coding RNA GCC2-AS1 Facilitates Malignant Phenotypes and Correlated With Unfavorable Prognosis for Lung Adenocarcinoma.
Yu F, Liang M, Wu W, Huang Y, Zheng J, Zheng B, Chen C. Yu F, et al. Front Oncol. 2021 Jan 26;10:628608. doi: 10.3389/fonc.2020.628608. eCollection 2020. Front Oncol. 2021. PMID: 33575222 Free PMC article.
Functional experiments were performed to investigate the effect of GCC2-AS1 on LUAD cells. Genes that were differentially expressed in GCC2-AS1-low and -high groups were analyzed by an enrichment analysis. ...Depletion of GCC2-AS1 inhibited the proliferation …
Functional experiments were performed to investigate the effect of GCC2-AS1 on LUAD cells. Genes that were differentially expressed i …
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N. Tu X, et al. Nat Commun. 2022 Nov 15;13(1):6977. doi: 10.1038/s41467-022-33765-0. Nat Commun. 2022. PMID: 36379959 Free PMC article.
Impairment of post-Golgi trafficking extends STING Golgi-dwell time, resulting in elevated immune signalling and protection against infection. Mechanistically, trans-Golgi coiled coil protein GCC2 and several RAB GTPases act as key regulators of STING post-Golgi traffickin …
Impairment of post-Golgi trafficking extends STING Golgi-dwell time, resulting in elevated immune signalling and protection against infectio …
Differential paired stage-specific expression of Babesia bovis cysteine-rich GCC2/GCC3 domain family proteins (BboGDP) during development within Rhipicephalus microplus.
Hussein HE, Johnson WC, Ueti MW. Hussein HE, et al. Parasit Vectors. 2023 Jan 17;16(1):16. doi: 10.1186/s13071-022-05628-6. Parasit Vectors. 2023. PMID: 36650585 Free PMC article.
The development of a transmission blocking vaccine to control bovine babesiosis requires the identification of antigens displayed on the surface of the parasite during its development within tick vectors. Four B. bovis cysteine-rich GCC2/GCC3 domain protein (BboGDP) family …
The development of a transmission blocking vaccine to control bovine babesiosis requires the identification of antigens displayed on the sur …
Case Report: Efficacy of ensartinib treatment in pulmonary inflammatory myofibroblastic tumor with a rare GCC2-ALK fusion.
He W, Ji X, Song C, Song S, Liu L. He W, et al. Front Oncol. 2022 Aug 8;12:934887. doi: 10.3389/fonc.2022.934887. eCollection 2022. Front Oncol. 2022. PMID: 36003768 Free PMC article.
Immunohistochemistry results showed that he was ALK positive, and next-generation sequencing revealed GCC2-ALK fusion in the IMT. The patient was administered first-line ensartinib 225-mg QD, which targeted GCC2-ALK fusion, and denosumab 120-mg Q4w anti-bone metasta …
Immunohistochemistry results showed that he was ALK positive, and next-generation sequencing revealed GCC2-ALK fusion in the IMT. The …
Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival.
Sun Z, Zhang Z, Banu K, Gibson IW, Colvin RB, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes TD, Djamali A, Gallon L, O'Connell PJ, He JC, Pober JS, Heeger PS, Menon MC. Sun Z, et al. J Clin Invest. 2023 Nov 1;133(21):e170420. doi: 10.1172/JCI170420. J Clin Invest. 2023. PMID: 37676733 Free PMC article.
In vitro GCC2 modulation impacted M6PR-dependent regulation of active TGF-beta1 and downstream signaling in T cells. Together, our data link LIMS1 locus D-R mismatches to DCGL via GCC2 eQTLs that modulate TGF-beta1-dependent effects on T cells....
In vitro GCC2 modulation impacted M6PR-dependent regulation of active TGF-beta1 and downstream signaling in T cells. Together, our da …
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Liang XH, Sun H, Hsu CW, Nichols JG, Vickers TA, De Hoyos CL, Crooke ST. Liang XH, et al. Nucleic Acids Res. 2020 Feb 20;48(3):1372-1391. doi: 10.1093/nar/gkz1171. Nucleic Acids Res. 2020. PMID: 31840180 Free PMC article.
Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activity. We found that reduction in cellular levels of GCC2 or M6PR impaired PS-ASO release from endosomes and decreased PS-ASO activity …
Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activ …
50 results