Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival.
Sun Z, Zhang Z, Banu K, Gibson IW, Colvin RB, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes TD, Djamali A, Gallon L, O'Connell PJ, He JC, Pober JS, Heeger PS, Menon MC.
Sun Z, et al.
J Clin Invest. 2023 Nov 1;133(21):e170420. doi: 10.1172/JCI170420.
J Clin Invest. 2023.
PMID: 37676733
Free PMC article.
In vitro GCC2 modulation impacted M6PR-dependent regulation of active TGF-beta1 and downstream signaling in T cells. Together, our data link LIMS1 locus D-R mismatches to DCGL via GCC2 eQTLs that modulate TGF-beta1-dependent effects on T cells....
In vitro GCC2 modulation impacted M6PR-dependent regulation of active TGF-beta1 and downstream signaling in T cells. Together, our da …