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Table representation of search results timeline featuring number of search results per year.

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1999 1
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2008 5
2009 3
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Page 1
GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer.
Jeong H, Choi BH, Park J, Jung JH, Shin H, Kang KW, Quan YH, Yu J, Park JH, Park Y, Choi Y, Kim HK, Hong S. Jeong H, et al. Cancers (Basel). 2021 Oct 31;13(21):5482. doi: 10.3390/cancers13215482. Cancers (Basel). 2021. PMID: 34771645 Free PMC article.
Receiver operating characteristic curve analysis revealed the diagnostic sensitivity and specificity of exosomal GCC2 to be 90% and 75%, respectively. A high area under the curve, 0.844, confirmed that GCC2 levels could effectively distinguish between the exosomes. …
Receiver operating characteristic curve analysis revealed the diagnostic sensitivity and specificity of exosomal GCC2 to be 90% and 7 …
Upregulation of Long Non-Coding RNA GCC2-AS1 Facilitates Malignant Phenotypes and Correlated With Unfavorable Prognosis for Lung Adenocarcinoma.
Yu F, Liang M, Wu W, Huang Y, Zheng J, Zheng B, Chen C. Yu F, et al. Front Oncol. 2021 Jan 26;10:628608. doi: 10.3389/fonc.2020.628608. eCollection 2020. Front Oncol. 2021. PMID: 33575222 Free PMC article.
Functional experiments were performed to investigate the effect of GCC2-AS1 on LUAD cells. Genes that were differentially expressed in GCC2-AS1-low and -high groups were analyzed by an enrichment analysis. ...Depletion of GCC2-AS1 inhibited the proliferation …
Functional experiments were performed to investigate the effect of GCC2-AS1 on LUAD cells. Genes that were differentially expressed i …
GCC2-ALK as a targetable fusion in lung adenocarcinoma and its enduring clinical responses to ALK inhibitors.
Jiang J, Wu X, Tong X, Wei W, Chen A, Wang X, Shao YW, Huang J. Jiang J, et al. Lung Cancer. 2018 Jan;115:5-11. doi: 10.1016/j.lungcan.2017.10.011. Epub 2017 Oct 27. Lung Cancer. 2018. PMID: 29290262
The functional study of GCC2-ALK was performed in Ba/F3 cells with cell proliferation and viability assays. ...Crizotinib treatment of the patient resulted in 18 months of progression free survival without any trace of GCC2-ALK fusion in the liquid biopsies. Re-biop …
The functional study of GCC2-ALK was performed in Ba/F3 cells with cell proliferation and viability assays. ...Crizotinib treatment o …
Rare GCC2-ALK fusion G13:A20 detected by next generation sequencing in non-small cell lung cancer patients and treatment response.
Qin J, Zeng D, Xie F, Yu R, Wu X, Liu K, Shao YW, Lu H, Jiang J. Qin J, et al. Transl Cancer Res. 2019 Sep;8(5):2187-2191. doi: 10.21037/tcr.2019.08.26. Transl Cancer Res. 2019. PMID: 35116968 Free PMC article.
Two patients with rare GCC2-ALK fusion G13:A20 which were found in Chinese population by next generation sequencing (NGS) developed resistant to crizotinib with a prolonged progression-free survival (PFS). ...In conclusion, non-small cell lung cancer (NSCLC) patients with …
Two patients with rare GCC2-ALK fusion G13:A20 which were found in Chinese population by next generation sequencing (NGS) developed r …
Case Report: Efficacy of ensartinib treatment in pulmonary inflammatory myofibroblastic tumor with a rare GCC2-ALK fusion.
He W, Ji X, Song C, Song S, Liu L. He W, et al. Front Oncol. 2022 Aug 8;12:934887. doi: 10.3389/fonc.2022.934887. eCollection 2022. Front Oncol. 2022. PMID: 36003768 Free PMC article.
Immunohistochemistry results showed that he was ALK positive, and next-generation sequencing revealed GCC2-ALK fusion in the IMT. The patient was administered first-line ensartinib 225-mg QD, which targeted GCC2-ALK fusion, and denosumab 120-mg Q4w anti-bone metasta …
Immunohistochemistry results showed that he was ALK positive, and next-generation sequencing revealed GCC2-ALK fusion in the IMT. The …
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N. Tu X, et al. Nat Commun. 2022 Nov 15;13(1):6977. doi: 10.1038/s41467-022-33765-0. Nat Commun. 2022. PMID: 36379959 Free PMC article.
Impairment of post-Golgi trafficking extends STING Golgi-dwell time, resulting in elevated immune signalling and protection against infection. Mechanistically, trans-Golgi coiled coil protein GCC2 and several RAB GTPases act as key regulators of STING post-Golgi traffickin …
Impairment of post-Golgi trafficking extends STING Golgi-dwell time, resulting in elevated immune signalling and protection against infectio …
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Liang XH, Sun H, Hsu CW, Nichols JG, Vickers TA, De Hoyos CL, Crooke ST. Liang XH, et al. Nucleic Acids Res. 2020 Feb 20;48(3):1372-1391. doi: 10.1093/nar/gkz1171. Nucleic Acids Res. 2020. PMID: 31840180 Free PMC article.
Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activity. We found that reduction in cellular levels of GCC2 or M6PR impaired PS-ASO release from endosomes and decreased PS-ASO activity …
Here, we examined the role of Golgi-endosome transport, specifically M6PR shuttling mediated by GCC2, in PS-ASO trafficking and activ …
A novel fusion gene involving PDGFRB and GCC2 in a chronic eosinophilic leukemia patient harboring t(2;5)(q37;q31).
Iriyama N, Takahashi H, Naruse H, Miura K, Uchino Y, Nakagawa M, Iizuka K, Hamada T, Hatta Y, Nakayama T, Takei M. Iriyama N, et al. Mol Genet Genomic Med. 2019 Apr;7(4):e00591. doi: 10.1002/mgg3.591. Epub 2019 Jan 29. Mol Genet Genomic Med. 2019. PMID: 30697976 Free PMC article.
Whole-genome sequencing was performed in peripheral blood leukocytes collected before imatinib therapy. RESULTS: A novel fusion gene between exon 22 of GCC2 and exon 12 of PDGFRB was detected and the presence of GCC2-PDGFRB was confirmed by PCR. CONCLUSION: This is …
Whole-genome sequencing was performed in peripheral blood leukocytes collected before imatinib therapy. RESULTS: A novel fusion gene between …
Differential paired stage-specific expression of Babesia bovis cysteine-rich GCC2/GCC3 domain family proteins (BboGDP) during development within Rhipicephalus microplus.
Hussein HE, Johnson WC, Ueti MW. Hussein HE, et al. Parasit Vectors. 2023 Jan 17;16(1):16. doi: 10.1186/s13071-022-05628-6. Parasit Vectors. 2023. PMID: 36650585 Free PMC article.
The development of a transmission blocking vaccine to control bovine babesiosis requires the identification of antigens displayed on the surface of the parasite during its development within tick vectors. Four B. bovis cysteine-rich GCC2/GCC3 domain protein (BboGDP) family …
The development of a transmission blocking vaccine to control bovine babesiosis requires the identification of antigens displayed on the sur …
Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9, Histological Changes and Renal Function in Experimental Nephrotoxicity Induced by Gentamicin.
Bulboacă AE, Porfire A, Bolboacă SD, Nicula CA, Feștilă DG, Roman A, Râjnoveanu RM, Râjnoveanu A, Dogaru G, Boarescu PM, Rus V, Bulboacă CA, Bulboacă AI, Stănescu I. Bulboacă AE, et al. Antioxidants (Basel). 2021 Feb 22;10(2):325. doi: 10.3390/antiox10020325. Antioxidants (Basel). 2021. PMID: 33671770 Free PMC article.
. = intraperitoneal), G-gentamicin (G, 80 mg/kg body weight (b.w.)), GCC1 and GCC2-with G and CC solution (single dose of 10 mg/kg b.w.-CC1, or 20 mg/kg b.w....
. = intraperitoneal), G-gentamicin (G, 80 mg/kg body weight (b.w.)), GCC1 and GCC2-with G and CC solution (single dose of 10 mg/kg b. …
44 results