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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 1
2007 4
2008 1
2009 2
2011 1
2013 1
2014 1
2015 1
2017 1
2018 1
2019 4
2020 3
2021 1
2022 2
2023 1
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25 results
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Page 1
Reprogramming to recover youthful epigenetic information and restore vision.
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Lu Y, et al. Among authors: church gm. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. Nature. 2020. PMID: 33268865 Free PMC article.
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity(1-3). ...
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of …
New intranasal and injectable gene therapy for healthy life extension.
Jaijyan DK, Selariu A, Cruz-Cosme R, Tong M, Yang S, Stefa A, Kekich D, Sadoshima J, Herbig U, Tang Q, Church G, Parrish EL, Zhu H. Jaijyan DK, et al. Among authors: church g. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2121499119. doi: 10.1073/pnas.2121499119. Epub 2022 May 10. Proc Natl Acad Sci U S A. 2022. PMID: 35537048 Free PMC article.
As the global elderly population grows, it is socioeconomically and medically critical to provide diverse and effective means of mitigating the impact of aging on human health. Previous studies showed that the adeno-associated virus (AAV) vector induced overexpression of c …
As the global elderly population grows, it is socioeconomically and medically critical to provide diverse and effective means of mitigating …
Regulation of lifespan by neural excitation and REST.
Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA. Zullo JM, et al. Among authors: church gm. Nature. 2019 Oct;574(7778):359-364. doi: 10.1038/s41586-019-1647-8. Epub 2019 Oct 16. Nature. 2019. PMID: 31619788 Free PMC article.
Notably, REST-deficient mice exhibit increased cortical activity and neuronal excitability during ageing. Similarly, loss-of-function mutations in the C. elegans REST orthologue genes spr-3 and spr-4 elevate neural excitation and reduce the lifespan of long-lived daf-2 mut …
Notably, REST-deficient mice exhibit increased cortical activity and neuronal excitability during ageing. Similarly, loss-of-function …
The Advent of Human Life Data Economics.
Zhavoronkov A, Church G. Zhavoronkov A, et al. Among authors: church g. Trends Mol Med. 2019 Jul;25(7):566-570. doi: 10.1016/j.molmed.2019.05.002. Epub 2019 Jun 27. Trends Mol Med. 2019. PMID: 31257078 Review.
The inherent challenges of classifying senescence-Response.
Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G. Calimport SRG, et al. Among authors: church g. Science. 2020 May 8;368(6491):595-596. doi: 10.1126/science.abb4073. Science. 2020. PMID: 32381713 No abstract available.
The Human Ageing Genomic Resources: online databases and tools for biogerontologists.
de Magalhães JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, Church GM. de Magalhães JP, et al. Among authors: church gm. Aging Cell. 2009 Feb;8(1):65-72. doi: 10.1111/j.1474-9726.2008.00442.x. Epub 2008 Nov 5. Aging Cell. 2009. PMID: 18986374 Free PMC article. Review.
To assist basic research on aging, we developed the Human Ageing Genomic Resources (HAGR). This work provides an overview of the databases and tools in HAGR and describes how the gerontology research community can employ them. ...AnAge is a database of aging …
To assist basic research on aging, we developed the Human Ageing Genomic Resources (HAGR). This work provides an overview of t …
To help aging populations, classify organismal senescence.
Calimport SRG, Bentley BL, Stewart CE, Pawelec G, Scuteri A, Vinciguerra M, Slack C, Chen D, Harries LW, Marchant G, Fleming GA, Conboy M, Antebi A, Small GW, Gil J, Lakatta EG, Richardson A, Rosen C, Nikolich K, Wyss-Coray T, Steinman L, Montine T, de Magalhães JP, Campisi J, Church G. Calimport SRG, et al. Among authors: church g. Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319. Science. 2019. PMID: 31672885 Free PMC article. No abstract available.
Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results.
Robinson-McCarthy LR, Mijalis AJ, Filsinger GT, de Puig H, Donghia NM, Schaus TE, Rasmussen RA, Ferreira R, Lunshof JE, Chao G, Ter-Ovanesyan D, Dodd O, Kuru E, Sesay AM, Rainbow J, Pawlowski AC, Wannier TM, Angenent-Mari NM, Najjar D, Yin P, Ingber DE, Tam JM, Church GM. Robinson-McCarthy LR, et al. Among authors: church gm. Microbiol Spectr. 2021 Oct 31;9(2):e0031321. doi: 10.1128/Spectrum.00313-21. Epub 2021 Sep 15. Microbiol Spectr. 2021. PMID: 34523989 Free PMC article.
Genomes optimize reproduction: aging as a consequence of the developmental program.
de Magalhães JP, Church GM. de Magalhães JP, et al. Among authors: church gm. Physiology (Bethesda). 2005 Aug;20:252-9. doi: 10.1152/physiol.00010.2005. Physiology (Bethesda). 2005. PMID: 16024513 Free article. Review.
One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein we review, revive, and refine the developmental theory of aging. Implications and experimental approaches for studying the progressive …
One hypothesis then is that the developmental program, optimized for reproduction, inadvertently regulates aging in mammals. Herein w …
25 results