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Year Number of Results
1996 1
1997 2
1998 2
2000 3
2001 1
2002 2
2020 1
2021 0
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12 results
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Page 1
Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease.
Del Balzo U, Signore PE, Walkinshaw G, Seeley TW, Brenner MC, Wang Q, Guo G, Arend MP, Flippin LA, Chow FA, Gervasi DC, Kjaergaard CH, Langsetmo I, Guenzler V, Liu DY, Klaus SJ, Lin A, Neff TB. Del Balzo U, et al. Among authors: gervasi dc. J Pharmacol Exp Ther. 2020 Aug;374(2):342-353. doi: 10.1124/jpet.120.265181. Epub 2020 Jun 2. J Pharmacol Exp Ther. 2020. PMID: 32487538
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Günzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr. Ivan M, et al. Among authors: gervasi dc. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64. doi: 10.1073/pnas.192342099. Epub 2002 Sep 26. Proc Natl Acad Sci U S A. 2002. PMID: 12351678 Free PMC article.
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme.
Toth M, Hernandez-Barrantes S, Osenkowski P, Bernardo MM, Gervasi DC, Shimura Y, Meroueh O, Kotra LP, Gálvez BG, Arroyo AG, Mobashery S, Fridman R. Toth M, et al. Among authors: gervasi dc. J Biol Chem. 2002 Jul 19;277(29):26340-50. doi: 10.1074/jbc.M200655200. Epub 2002 May 9. J Biol Chem. 2002. PMID: 12004057 Free article.
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
Toth M, Bernardo MM, Gervasi DC, Soloway PD, Wang Z, Bigg HF, Overall CM, DeClerck YA, Tschesche H, Cher ML, Brown S, Mobashery S, Fridman R. Toth M, et al. Among authors: gervasi dc. J Biol Chem. 2000 Dec 29;275(52):41415-23. doi: 10.1074/jbc.M006871200. J Biol Chem. 2000. PMID: 10998420 Free article.
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