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Year Number of Results
2006 1
2008 1
2010 6
2011 3
2012 3
2013 3
2014 2
2015 2
2016 5
2017 4
2018 4
2019 5
2020 6
2021 3
2022 2
2023 8
2024 4

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57 results

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Page 1
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D. Klemm T, et al. Among authors: geurink pp. EMBO J. 2020 Sep 15;39(18):e106275. doi: 10.15252/embj.2020106275. Epub 2020 Aug 26. EMBO J. 2020. PMID: 32845033 Free PMC article.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Shin D, et al. Among authors: geurink pp. Nature. 2020 Nov;587(7835):657-662. doi: 10.1038/s41586-020-2601-5. Epub 2020 Jul 29. Nature. 2020. PMID: 32726803 Free PMC article.
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A. Gan J, et al. Among authors: geurink pp. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055744 Free PMC article.
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes.
van Tol BDM, van Doodewaerd BR, Lageveen-Kammeijer GSM, Jansen BC, Talavera Ormeño CMP, Hekking PJM, Sapmaz A, Kim RQ, Moutsiopoulou A, Komander D, Wuhrer M, van der Heden van Noort GJ, Ovaa H, Geurink PP. van Tol BDM, et al. Among authors: geurink pp. Nat Commun. 2023 Mar 25;14(1):1661. doi: 10.1038/s41467-023-37363-6. Nat Commun. 2023. PMID: 36966155 Free PMC article.
A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity.
Pérez Berrocal DA, Vishwanatha TM, Horn-Ghetko D, Botsch JJ, Hehl LA, Kostrhon S, Misra M, Ðikić I, Geurink PP, van Dam H, Schulman BA, Mulder MPC. Pérez Berrocal DA, et al. Among authors: geurink pp. Angew Chem Int Ed Engl. 2023 Aug 7;62(32):e202303319. doi: 10.1002/anie.202303319. Epub 2023 Jun 27. Angew Chem Int Ed Engl. 2023. PMID: 37272691
Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2.
Gan J, de Vries J, Akkermans JJLL, Mohammed Y, Tjokrodirijo RTN, de Ru AH, Kim RQ, Vargas DA, Pol V, Fasan R, van Veelen PA, Neefjes J, van Dam H, Ovaa H, Sapmaz A, Geurink PP. Gan J, et al. Among authors: geurink pp. ACS Chem Biol. 2023 Sep 15;18(9):2003-2013. doi: 10.1021/acschembio.3c00227. Epub 2023 Aug 29. ACS Chem Biol. 2023. PMID: 37642399 Free PMC article.
Dedicated bacterial esterases reverse lipopolysaccharide ubiquitylation to block immune sensing.
Szczesna M, Huang Y, Lacoursiere RE, Bonini F, Pol V, Koc F, Ward B, Geurink PP, Pruneda JN, Thurston TLM. Szczesna M, et al. Among authors: geurink pp. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-2986327. doi: 10.21203/rs.3.rs-2986327/v1. Res Sq. 2023. Update in: Cell Host Microbe. 2024 Jun 12;32(6):913-924.e7. doi: 10.1016/j.chom.2024.04.012. PMID: 37503018 Free PMC article. Updated. Preprint.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N. Resnick E, et al. Among authors: geurink pp. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22. J Am Chem Soc. 2019. PMID: 31060360 Free PMC article.
57 results