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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1874 1
1893 1
1894 1
1903 1
1911 1
1914 1
1919 1
1924 1
1927 1
1930 1
1943 1
1944 2
1946 1
1947 1
1951 3
1952 1
1953 1
1954 1
1956 2
1957 1
1958 4
1959 2
1960 2
1961 2
1962 2
1963 3
1964 7
1965 6
1966 12
1967 8
1968 8
1969 19
1970 16
1971 27
1972 41
1973 41
1974 60
1975 193
1976 274
1977 221
1978 231
1979 235
1980 289
1981 354
1982 345
1983 424
1984 562
1985 598
1986 645
1987 714
1988 791
1989 894
1990 1049
1991 1049
1992 1102
1993 1198
1994 1156
1995 1194
1996 1328
1997 1305
1998 1329
1999 1361
2000 1423
2001 1329
2002 1321
2003 1384
2004 1505
2005 1484
2006 1467
2007 1516
2008 1538
2009 1562
2010 1593
2011 1610
2012 1674
2013 1776
2014 2030
2015 2171
2016 2185
2017 2276
2018 2512
2019 2781
2020 3196
2021 3695
2022 3681
2023 3474
2024 1251

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64,040 results

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Page 1
Musculoskeletal Effects of Altered GH Action.
Young JA, Zhu S, List EO, Duran-Ortiz S, Slama Y, Berryman DE. Young JA, et al. Front Physiol. 2022 May 19;13:867921. doi: 10.3389/fphys.2022.867921. eCollection 2022. Front Physiol. 2022. PMID: 35665221 Free PMC article. Review.
In addition to its metabolic and musculoskeletal effects, GH is closely associated with aging, with levels declining as individuals age but GH action negatively correlating with lifespan. GH's effects have been studied in human conditions of GH alterat …
In addition to its metabolic and musculoskeletal effects, GH is closely associated with aging, with levels declining as individuals a …
Genetic disorders of GH action pathway.
Domené HM, Fierro-Carrión G. Domené HM, et al. Growth Horm IGF Res. 2018 Feb;38:19-23. doi: 10.1016/j.ghir.2017.12.004. Epub 2017 Dec 12. Growth Horm IGF Res. 2018. PMID: 29249625 Review.
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, and lack of IGF-I response to GH treatment, IGF-I resistance is characterized by elevated IGF-I levels with normal/high GH levels. ...Complete GH
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, and lack of IGF-I response …
GH and bone--experimental and clinical studies.
Isaksson OG, Ohlsson C, Bengtsson BA, Johannsson G. Isaksson OG, et al. Endocr J. 2000 Mar;47 Suppl:S9-16. doi: 10.1507/endocrj.47.supplmarch_s9. Endocr J. 2000. PMID: 10890175 Free article. Review.
GH treatment also increases bone mass and the total mechanical strength of bones in rats with normal GH secretion. Because of the short duration of GH-treatment in man with normal GH secretion, the effect on bone mass is still inconclusive. ...
GH treatment also increases bone mass and the total mechanical strength of bones in rats with normal GH secretion. Because of
The GH/IGF-1 axis in chronic heart failure.
Arcopinto M, Bobbio E, Bossone E, Perrone-Filardi P, Napoli R, Sacca L, Cittadini A. Arcopinto M, et al. Endocr Metab Immune Disord Drug Targets. 2013 Mar;13(1):76-91. doi: 10.2174/1871530311313010010. Endocr Metab Immune Disord Drug Targets. 2013. PMID: 23369140 Review.
Impaired activity of the GH/IGF-1 axis in CHF has been described by several independent groups and includes a wide array of abnormalities, including low IGF-1 levels, GH deficiency (GHD), and GH resistance that may be related to the severity of heart disease. …
Impaired activity of the GH/IGF-1 axis in CHF has been described by several independent groups and includes a wide array of abnormali …
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis.
Locatelli V, Bianchi VE. Locatelli V, et al. Int J Endocrinol. 2014;2014:235060. doi: 10.1155/2014/235060. Epub 2014 Jul 23. Int J Endocrinol. 2014. PMID: 25147565 Free PMC article. Review.
Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administration, and seven related to the GH/IGF-1 effect on bone healing. ...GH interacts with sex steroids in the anabolic process. …
Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administ …
Novel long-acting GH preparations.
Doknic M, Stojanovic M, Popovic V. Doknic M, et al. Pediatr Endocrinol Rev. 2014 Dec;12(2):206-12. Pediatr Endocrinol Rev. 2014. PMID: 25581986 Review.
Currently a variety of modified GH molecules which delay GH clearance (CTP modified GH, recombinant polypeptide XTEN, GH conjugated with albumin, GH linked to immunoglobulin) are studied and the ongoing studies are in different phases (from I-II …
Currently a variety of modified GH molecules which delay GH clearance (CTP modified GH, recombinant polypeptide XTEN, …
Metabolic consequences of GH deficiency.
Jørgensen JO, Vestergaard E, Gormsen L, Jessen N, Nørrelund H, Christiansen JS, Møller N. Jørgensen JO, et al. J Endocrinol Invest. 2005;28(5 Suppl):47-51. J Endocrinol Invest. 2005. PMID: 16114276 Review.
Surprisingly, however, hypopituitary adults with unsubstituted GH deficiency tend to be insulin resistant which may worsen during GH substitution. ...The best way to address this challenge is to employ evening administration of GH and to tailor the dose. Insu …
Surprisingly, however, hypopituitary adults with unsubstituted GH deficiency tend to be insulin resistant which may worsen during …
Laboratory assessment of GH.
Strasburger CJ. Strasburger CJ. Growth Horm IGF Res. 1998 Feb;8 Suppl A:41-6. doi: 10.1016/s1096-6374(98)80008-7. Growth Horm IGF Res. 1998. PMID: 10993590 Review.
Final proof of the diagnosis, however, is sought by measurement of GH levels in serum after dynamic provocative testing of GH secretion. ...Ideally, GH should be measured by a true somatogenic bioassay. Such assays are too cumbersome for routine use, however, …
Final proof of the diagnosis, however, is sought by measurement of GH levels in serum after dynamic provocative testing of GH
GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.
List EO, Berryman DE, Buchman M, Jensen EA, Funk K, Duran-Ortiz S, Qian Y, Young JA, Slyby J, McKenna S, Kopchick JJ. List EO, et al. Endocrinology. 2019 Jul 1;160(7):1743-1756. doi: 10.1210/en.2019-00167. Endocrinology. 2019. PMID: 31099824 Free PMC article.
However, because GH replacement studies cannot be performed using this line, a GH knockout mouse line via targeted disruption of the GH gene is needed. Therefore, we created and characterized GH gene-disrupted (GH-/-) mice. GH-/- mice hav …
However, because GH replacement studies cannot be performed using this line, a GH knockout mouse line via targeted disruption …
Optimizing gh therapy in adults and children.
Drake WM, Howell SJ, Monson JP, Shalet SM. Drake WM, et al. Endocr Rev. 2001 Aug;22(4):425-50. doi: 10.1210/edrv.22.4.0438. Endocr Rev. 2001. PMID: 11493578 Review.
The safe clinical practice of GH replacement demands a method of judging overall GH status, but there is no biological marker in adults that is the equivalent of linear growth in a child by which to judge the efficacy of GH replacement. ...It is clear that th …
The safe clinical practice of GH replacement demands a method of judging overall GH status, but there is no biological marker …
64,040 results
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